Thymectomy and malignancy

Masaoka, Akira; Yamakawa, Yosuke; Niwa, Hiroshi; Fukai, Ichiro; Saito, Yasutoshi; Tokudome, Shinkan; Nakahara, Keiichi; Fujii, Yoshiko

doi:10.1016/1010-7940(94)90155-4

Cited by 95 publications

(59 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, Bulkley et al 37 observed no increase in malignancies among patients who underwent thymic resection for myasthenia gravis, except when the myasthenia gravis was accompanied by thymoma. 8 Similarly, Masaoka et al 38 analyzed 390 patients with myasthenia gravis who had undergone thymic resections and found no increase in the extrathymic malignancy rate among those without an associated thymoma. In contrast, patients with thymoma and myasthenia gravis who underwent thymic resection had an observed-to-expected malignancy ratio of 3:42.…”

Section: Treatment-induced Malignanciesmentioning

confidence: 99%

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Welsh¹,

Thurman²,

Howard³

2003

Clinical Medicine & Research

View full text Add to dashboard Cite

The presence of five discrete synchronous or metachronous primary neoplasms in a single patient is an extremely rare event. This is a report of a patient with a malignant (invasive) thymoma and four other independent primary neoplasms including: gliosarcoma, papillary thyroid cancer, meningioma and metastatic adenocarcinoma of the colon, found synchronously at autopsy. Thymoma patients appear to have an inherent predisposition towards developing additional neoplasms. Other than the thymoma, the presented patient had no obvious risk factors for neoplasia. This case provides evidence for an unusual syndrome of thymoma and multiple primary neoplasms. Further research is required to elucidate the mechanism of this association. Meanwhile, heightened awareness of this association may allow earlier detection and treatment of additional cancers in patients with a history of thymoma.

show abstract

Section: Treatment-induced Malignanciesmentioning

confidence: 99%

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Welsh¹,

Thurman²,

Howard³

2003

Clinical Medicine & Research

View full text Add to dashboard Cite

show abstract

“…23 Hay una relación muy estrecha entre ambos sistemas de clasificación, los pacientes clasificados como tipos B2, B3 y C corresponden a los estadios III y IV de Masaoka. 8,13 Otras clasificaciones son las de Müller-Hermelink y la de Suster y Morán, pero actualmente no se usan 24,25 (Cuadro 2).…”

Section: Introductionunclassified

Carcinoma tímico en niños. Informe de dos casos

et al. 2015

View full text Add to dashboard Cite

Carcinoma tímico en niños. Informe de dos casosThymic carcinoma in pediatric population: report of two cases RESUMEN El carcinoma tímico es una neoplasia poco frecuente en la población pediátrica. El diagnóstico diferencial se realiza con tumores mediastinales. Generalmente las manifestaciones clínicas se deben a obstrucción de la vía aérea. El tratamiento incluye cirugía, quimioterapia y radioterapia. Los esquemas de tratamiento, especialmente la quimioterapia, es motivo de controversia en niños y la mayoría de los protocolos se basan en la experiencia obtenida de los adultos. El pronóstico es malo, con pocas posibilidades de curación, depende del estadio según la clasificación de Masaoka y de la posibilidad de resección quirúrgica.En este informe se describen dos casos de carcinoma tímico en niños: uno de 12 años cuya afección se inició con cianosis e hipercalcemia y en una paciente de 14 años en quien empezó con tos y dolor torácico. ABSTRACTThymic carcinoma is a rare tumor in pediatric population. Differential diagnoses include mediastinal tumors. Most clinical manifestations are due to obstruction. Treatment includes surgery, chemotherapy and radiotherapy. The treatment schemes, especially chemotherapy, are controversial in children, and most of them are based on the experience with adult patients. In general, thymic carcinoma has a poor prognosis, with low chances for cure, and it is based on Masaoka et al classification and the possibility of surgical resection.We report two cases of thymic carcinoma in children: a 12-year-old boy who presented with cyanosis and hypercalcemia, and a 14-year-old girl whose inicial symptoms were cough and chest pain.

show abstract

“…No intraoperative or postoperative mortality occurred. Ten patients (11.3%) developed postoperative complications: pneumonia (n ϭ 4 patients), respiratory failure because of MG crisis (n ϭ 2 patients), surgical wound infections (n ϭ 5 patients), and prolonged air 5,6 ). The median follow-up period was 70 months (range, 3-216 mos).…”

Section: Clinicopathologic Findingsmentioning

confidence: 99%

“…Staging was based on surgical and pathologic criteria as described by Masaoka et al 5,6 and was retrospectively performed at the time of the review of the surgeon's pathology and surgical notes. The morphologic classification of the thymomas was conducted according to the specifications of Bernatz et al, 11 Marino and Muller-Hermelink, 12 and the WHO.…”

Section: Patientsmentioning

confidence: 99%

Long‐term disease‐free survival of patients with radically resected thymomas

Mineo

Ambrogi

Mineo

et al. 2005

Cancer

View full text Add to dashboard Cite

BACKGROUNDDespite radical surgical resection, thymomas often recur. The objective of the current retrospective study was to investigate the prognostic relevance of the expression of cell‐cycle proteins in these neoplasms to formulate a possible therapeutic surveillance strategy for the prevention of recurrence.METHODSThe authors retrospectively reviewed the main clinicopathologic factors, including the World Health Organization (WHO) classification, of patients with thymoma who had undergone radical surgical resection. Specimens were studied using immunohistochemistry and the expression of cell‐cycle proteins (i.e., p21, p27, and p53) was assessed. Univariate and multivariate analysis of predicting survival prognostic factors were performed.RESULTSThe authors analyzed 88 patients with thymoma who underwent radical surgical resection at the study institution. According to the Masaoka staging system, 41 patients had Stage I disease, 31 patients had Stage II disease, and 16 patients had Stage III disease. There were 24 tumor recurrences (27.3%), 4 of which were local, 16 of which were distant intrathoracic, and 4 of which were extrathoracic. The second radical resection provided a disease‐free survival rate that was similar to the first. Only Masaoka stage (P = 0.001), WHO classification (P=0.001), high expression of p53 (P=0.03), and low expression of p21 (P=0.02) and p27 (P=0.001) were found to be correlated with a reduced disease‐free survival. Low p27 expression was found to be the most significant predictive factor of a short disease‐free survival (P=0.001), especially when associated with low p21 expression and high p53 expression (P=0.0001).CONCLUSIONSLong‐term disease‐free survival in thymoma patients treated with radical surgical resection was found to be correlated with Masaoka stage, WHO classification, and expression of cell‐cycle proteins, with the latter found to be the most significant predictive factor. Functional cooperation between cell‐cycle proteins might constitute another level of regulation in tumor growth. More careful surveillance should be adopted whenever there is negative cell‐cycle protein expression. Cancer 2005. © 2005 American Cancer Society.

show abstract

Thymectomy and malignancy

Cited by 95 publications

References 0 publications

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Carcinoma tímico en niños. Informe de dos casos

Long‐term disease‐free survival of patients with radically resected thymomas

Contact Info

Product

Resources

About