Thyme Oil Nanoemulsion Enhanced Cellular Antioxidant and Suppressed Inflammation in Mice Challenged by Cadmium-Induced Oxidative Stress

Rahmani, Fatemeh; Nabi, S.U.; Idliki, Reza Baratpour; Alimirzaei, Masoumeh; Barkhordar, Seyed Mohammad Adel; Shafaei, Negin; Zareian, Mohsen; Karimi, Ehsan; Oskoueian, Ehsan

doi:10.1007/s12649-022-01738-5

Cited by 5 publications

(4 citation statements)

References 31 publications

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“…These plants are widely grown, but their exploitation requires adapted solutions for biomass management. Among these, Artemisia annua [1], Camellia sinensis [5], Ricinus communis [6], Mentha arvensis [7], and Thymus vulgaris [8] constitute good examples. Their byproducts are the subjects of several studies focusing on extracting antioxidants, anti-inflammatory, and cellulosic materials used in cosmetic, medicinal, and polymer applications.…”

Section: Introductionmentioning

confidence: 99%

Major Phytochemical Compounds, In Vitro Antioxidant, Antibacterial, and Antifungal Activities of Six Aqueous and Organic Extracts of Crocus sativus L. Flower Waste

Lachguer

Merzougui

Boudadi

et al. 2022

Waste Biomass Valor

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Purpose After being considered as a neglected product, agricultural waste is nowadays considered of paramount importance. It has become a source of many chemical compounds with industrial, pharmaceutical, and food applications. This study aims to evaluate the primary phytochemical content, the antioxidant properties, and the antimicrobial activities of different extracts of saffron flower waste (SFE) against bacterial and fungal strains involved in diverse pathologies in southern Morocco. Methods Total phenolic and flavonoid contents were determined. The antioxidant potentials were assessed by DPPH, FRAP, and β-carotene assays. The antimicrobial activity against four bacteria and four fungi was also evaluated. The findings in terms of the relationships between phytochemical content and all activities were depicted by PCA analyses. Results SFEs contained large amounts of phenolic and flavonoid compounds that contribute to the significant antioxidant activities. Diethyl ether (DE), n-Butanol (n-B), and Ethyl acetate (EA) fractions respectively exhibited more DPPH scavenging capacity, FRAP reducing power, and β-carotene bleaching inhibition. DE and EA have a remarkable effect mainly against Staphylococcus aureus strain, compared to Listeria monocytogenes, Escherichia coli and Klebsiella pneumoniae. Both SFEs showed antifungal antagonism towards key fungi species involved in post-harvest mold and crop yield losses. Botrytis cinerea was more susceptible than Fusarium solani, Penicillium expansum, and Penicillium digitatum. Conclusion These results reveal new data about extracts obtained from SFE that could be a potential source of natural antioxidant and antimicrobial agents opening new possibilities for their applications in the food system as a natural preservative and a sustainable alternative to conventional ingredients.

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Section: Introductionmentioning

confidence: 99%

Major Phytochemical Compounds, In Vitro Antioxidant, Antibacterial, and Antifungal Activities of Six Aqueous and Organic Extracts of Crocus sativus L. Flower Waste

Lachguer

Merzougui

Boudadi

et al. 2022

Waste Biomass Valor

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show abstract

“…In the present study, thyme oil with its antiinflammatory properties was able to reduce the expression of proinflammatory cytokines such as IL-6 and TNF-α in the liver tissue. With reducing oxidative stress and inflammation and increasing antioxidant activity [32,33], in the present study, liver function is improved by the reduction of serum ALT, AST, and ALP. Thyme extract improves dexamethasone-induced hepatotoxicity by reducing the activity of liver enzymes and by increasing the antioxidant activity of the liver [34].…”

Section: Discussionmentioning

confidence: 72%

“…5 BioMed Research International cadmium levels and inflammation, and improve antioxidant capacity in the liver [33]. Thyme essential oil containing carvacrol reduces renal and neurotoxicity induced by insecticide voliam targo [36].…”

Section: Discussionmentioning

confidence: 99%

“…According to previous studies, TE contains phenolic compounds, and after administration to rats with cadmium toxicity, it reduces lipid peroxidation and oxidative stress in liver tissue. Caryophyllene and linalool, as the main active ingredients in thyme, improve weight, reduce cadmium levels and inflammation, and improve antioxidant capacity in the liver [ 33 ]. Thyme essential oil containing carvacrol reduces renal and neurotoxicity induced by insecticide voliam targo [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Thyme Essential Oil on Liver Injuries Caused by Renal Ischemia-Reperfusion in Rats

Rostami

Eslamifar

Nazemi

et al. 2022

BioMed Research International

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Liver damage occurs following renal ischemia-reperfusion (RIR) that can cause inflammation and inflammatory cytokines activated after kidney injury. In this study, thyme essential oil (TE) with antioxidant and anti-inflammatory properties was used to reduce liver damage induced by renal IR. 32 male rats were randomly divided into 4 equal groups: (1) control, (2) RIR, (3) RIR+TE, and (4) TE. Rats received TE as a pretreatment at a dose of 0.5 ml/kg for one week. Then, under anesthesia for 45 minutes for ischemia, the kidneys of the animals were closed with clamps, and reperfusion was performed for 24 hours. Animal serum was isolated to evaluate alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) parameters. The liver of rats was examined for the measurement of malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), and expression of genes such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and caspase-3. ALP, AST, ALT, MDA, NO, IL-6, TNF-α, and caspase-3 increased significantly in the RIR group compared to the control group ( p < 0.05 ). GSH, GPX, and CAT decreased significantly in the RIR group compared to the control group ( p < 0.05 ). TE caused a decrease in ALP, AST, ALT, MDA, NO, IL-6, and TNF-α compared to the RIR group and caused an increase in the amount of GSH, GPX, and CAT in the RIR group ( p < 0.05 ). This study showed that TE has antioxidant and anti-inflammatory properties that reduce liver damage induced by RIR.

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Formulation, characterization and evaluation of anti-breast cancer activity of 2-carene nanoemulsion; in silico, in vitro and in vivo study

Nayila,

Sharif,

Shahzad Lodhi

et al. 2024

Arabian Journal of Chemistry

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Thyme Oil Nanoemulsion Enhanced Cellular Antioxidant and Suppressed Inflammation in Mice Challenged by Cadmium-Induced Oxidative Stress

Cited by 5 publications

References 31 publications

Major Phytochemical Compounds, In Vitro Antioxidant, Antibacterial, and Antifungal Activities of Six Aqueous and Organic Extracts of Crocus sativus L. Flower Waste

Major Phytochemical Compounds, In Vitro Antioxidant, Antibacterial, and Antifungal Activities of Six Aqueous and Organic Extracts of Crocus sativus L. Flower Waste

The Effect of Thyme Essential Oil on Liver Injuries Caused by Renal Ischemia-Reperfusion in Rats

Formulation, characterization and evaluation of anti-breast cancer activity of 2-carene nanoemulsion; in silico, in vitro and in vivo study

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