Thymbra capitata Essential Oil Prevents Cell Death Induced by 4-Hydroxy-2-Nonenal in Neonatal Rat Cardiac Myocytes

Hortigón-Vinagre, María P.; Blanco, José; Ruiz, Trinidad; Henao, Fernando

doi:10.1055/s-0034-1383051

Cited by 10 publications

(11 citation statements)

References 37 publications

(48 reference statements)

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“…It was first important to characterize hydrosol composition by SPME GC-MS in comparison with that of the original essential oil. The main constituents of the T. capitata EO were oxygenated phenolic monoterpene carvacrol, monocyclic monoterpene ␥-terpinene, and the alkylbenzene p-cymene, as found in previous studies (54)(55)(56). However, the carvacrol content in this study was much lower (20%) than previous reported concentrations (60% to 70%).…”

Section: Discussionsupporting

confidence: 62%

Hydrosol of Thymbra capitata Is a Highly Efficient Biocide against Salmonella enterica Serovar Typhimurium Biofilms

Karampoula

Giaouris

Deschamps

et al. 2016

Appl Environ Microbiol

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Salmonella is recognized as one of the most significant enteric foodborne bacterial pathogens. In recent years, the resistance of pathogens to biocides and other environmental stresses, especially when they are embedded in biofilm structures, has led to the search for and development of novel antimicrobial strategies capable of displaying both high efficiency and safety. In this direction, the aims of the present work were to evaluate the antimicrobial activity of hydrosol of the Mediterranean spice Thymbra capitata against both planktonic and biofilm cells of Salmonella enterica serovar Typhimurium and to compare its action with that of benzalkonium chloride (BC), a commonly used industrial biocide. In order to achieve this, the disinfectant activity following 6-min treatments was comparatively evaluated for both disinfectants by calculating the concentrations needed to achieve the same log reductions against both types of cells. Their bactericidal effect against biofilm cells was also comparatively determined by in situ and real-time visualization of cell inactivation through the use of time-lapse confocal laser scanning microscopy (CLSM). Interestingly, results revealed that hydrosol was almost equally effective against biofilms and planktonic cells, whereas a 200-times-higher concentration of BC was needed to achieve the same effect against biofilm compared to planktonic cells. Similarly, time-lapse CLSM revealed the significant advantage of the hydrosol to easily penetrate within the biofilm structure and quickly kill the cells, despite the three-dimensional (3D) structure of Salmonella biofilm. IMPORTANCEThe results of this paper highlight the significant antimicrobial action of a natural compound, hydrosol of Thymbra capitata, against both planktonic and biofilm cells of a common foodborne pathogen. Hydrosol has numerous advantages as a disinfectant of food-contact surfaces. It is an aqueous solution which can easily be rinsed out from surfaces, it does not have the strong smell of the essential oil (EO) and it is a byproduct of the EO distillation procedure without any industrial application until now. Consequently, hydrosol obviously could be of great value to combat biofilms and thus to improve product safety not only for the food industries but probably also for many other industries which experience biofilm-related problems.

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Section: Discussionsupporting

confidence: 62%

Hydrosol of Thymbra capitata Is a Highly Efficient Biocide against Salmonella enterica Serovar Typhimurium Biofilms

Karampoula

Giaouris

Deschamps

et al. 2016

Appl Environ Microbiol

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“…Several papers have been published on the chemical composition of the essential oil of T. capitatus (Cosentino et al, 1999;Arras and Usai, 2001;Miceli et al, 2006;El Ajjouri et al, 2008;Figueiredo et al, 2008;Blanco et al, 2010;Napoli et al, 2010;Tawaha and Hudaib, 2012;Yvon et al, 2012;BallesterCosta et al, 2013;Chedia et al, 2013;Saoud et al, 2013;Hortigo´n-Vinagre et al, 2014;Bouayad Alam et al, 2014). It is very rich in the terpenes thymol, carvacrol, and p-cymene.…”

Section: Introductionmentioning

confidence: 99%

Influence of harvesting time on composition of the essential oil of Thymus capitatus (L.) Hoffmanns. & Link. growing wild in northern Sicily and its activity on microorganisms affecting historical art crafts

Casiglia

Bruno

Scandolera

et al. 2019

Arabian Journal of Chemistry

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One of the main factors affecting historical art crafts material is the biodeterioration performed by bacteria and fungi, in archives, museums or private collections. Several microorganisms cause degradation to the natural organic material such as fibers, woods, and dyes as well as to stone objects. These alterations produce deterioration of physical, chemical, mechanical and esthetic properties. Consequently, in this publication, we report the high antibacterial and antifungal activities of wild thyme essential oil, oil that can be used as an alternative natural tool in the fight against microorganisms affecting historical art crafts.Essential oil of the Thymus capitatus growing wild in northern Sicily has been extracted by hydrodistillation from aerial parts collected at different growth times. The constituents of the essential oil have been characterized by gas chromatography (GC) and GC-mass spectrometry.

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“…Thymbra capitata is a Mediterranean culinary herb. Its essential oil prevents 4-HNE-induced cell death and avoids mitochondrial membrane potential loss and ROS generation in primary cultures of neonatal rat cardiomyocytes [15]. Olive (Olea europaea) leaf, a popular traditional herbal medicine, has a cardioprotective function.…”

Section: Protection Against Cardiovascular Injurymentioning

confidence: 99%

“…Some of them have been suggested to be attractive sources of potential agents to mitigate oxidative stress and attenuate 4-HNE-induced toxicity. However, researchers pay little attention to reviewing these medicinal plants and natural bioactive compounds on combating 4-HNE-induced deleterious effects in neurotoxicity and neurological disorder, eye damage, cardiovascular injury, liver injury, and energy metabolism disorder [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?

Wang

et al. 2020

Biomolecules

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The toxic reactive aldehyde 4-hydroxynonenal (4-HNE) belongs to the advanced lipid peroxidation end products. Accumulation of 4-HNE and formation of 4-HNE adducts induced by redox imbalance participate in several cytotoxic processes, which contribute to the pathogenesis and progression of oxidative stress-related human disorders. Medicinal plants and bioactive natural compounds are suggested to be attractive sources of potential agents to mitigate oxidative stress, but little is known about the therapeutic potentials especially on combating 4-HNE-induced deleterious effects. Of note, some investigations clarify the attenuation of medicinal plants and bioactive compounds on 4-HNE-induced disturbances, but strong evidence is needed that these plants and compounds serve as potent agents in the prevention and treatment of disorders driven by 4-HNE. Therefore, this review highlights the pharmacological basis of these medicinal plants and bioactive compounds to combat 4-HNE-induced deleterious effects in oxidative stress-related disorders, such as neurotoxicity and neurological disorder, eye damage, cardiovascular injury, liver injury, and energy metabolism disorder. In addition, this review briefly discusses with special attention to the strategies for developing potential therapies by future applications of these medicinal plants and bioactive compounds, which will help biological and pharmacological scientists to explore the new vistas of medicinal plants in combating 4-HNE-induced deleterious effects.

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Thymbra capitata Essential Oil Prevents Cell Death Induced by 4-Hydroxy-2-Nonenal in Neonatal Rat Cardiac Myocytes

Cited by 10 publications

References 37 publications

Hydrosol of Thymbra capitata Is a Highly Efficient Biocide against Salmonella enterica Serovar Typhimurium Biofilms

Hydrosol of Thymbra capitata Is a Highly Efficient Biocide against Salmonella enterica Serovar Typhimurium Biofilms

Influence of harvesting time on composition of the essential oil of Thymus capitatus (L.) Hoffmanns. & Link. growing wild in northern Sicily and its activity on microorganisms affecting historical art crafts

Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?

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