Thy-1: a lymphoid cell subset marker capable of delivering an activation signal to mouse T lymphocytes

Pont, Suzanne

doi:10.1016/0300-9084(87)90022-8

Cited by 20 publications

(27 citation statements)

References 56 publications

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“…In contrast, human Thy-1 contains only two glycosylation sites (12). Thy-1 is one of the most heavily glycosylated membrane proteins with a carbohydrate content up to 30% of its molecular mass (11). The composition of Thy-1 carbohydrate moieties varies considerably between different tissues in the same animal, and even among cells of the same lineage at different stages of ontogeny.…”

Section: Structure Tissue Distribution and Interspecies Variationsmentioning

confidence: 99%

“…The core protein of 25-kDa rodent Thy-1 consists of 111 or 112 aa, and is N-glycosylated at three sites (11). In contrast, human Thy-1 contains only two glycosylation sites (12).…”

Section: Structure Tissue Distribution and Interspecies Variationsmentioning

confidence: 99%

“…Thy-1 homologs have been described in many species, including squid, frogs, chickens, mice, rats, dogs, and humans (8,11). The locus for murine Thy-1 maps to chromosome 9 and includes two alleles termed Thy-1 a and Thy-1 b , which code for Thy-1.1 and Thy-1.2 glycoproteins, respectively.…”

Section: Structure Tissue Distribution and Interspecies Variationsmentioning

confidence: 99%

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Thy-1: More than a Mouse Pan-T Cell Marker

Haeryfar

Hoskin

2004

The Journal of Immunology

156

152

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Thy-1 (CD90) is a small GPI-anchored protein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells. T cell proliferation and cytokine synthesis in response to Thy-1 cross-linking by specific mAb suggests a role for Thy-1 in mouse T lymphocyte activation. However, a physiological ligand or counterreceptor for murine Thy-1 in the lymphoid compartment has not yet been identified. Thy-1 cross-linking, in the context of strong costimulatory signaling through CD28, results in an activating signal that can at least partially substitute for TCR signaling during mouse T cell activation. Remarkably, Thy-1 cross-linking also results in the potent costimulation of T cells activated through the TCR. This novel dual signaling capacity suggests a possible role for Thy-1 in the maintenance of T cell homeostasis in the absence of TCR triggering, as well as potentiating Ag-induced T cell responses.

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Section: Structure Tissue Distribution and Interspecies Variationsmentioning

confidence: 99%

“…The core protein of 25-kDa rodent Thy-1 consists of 111 or 112 aa, and is N-glycosylated at three sites (11). In contrast, human Thy-1 contains only two glycosylation sites (12).…”

Section: Structure Tissue Distribution and Interspecies Variationsmentioning

confidence: 99%

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Thy-1: More than a Mouse Pan-T Cell Marker

Haeryfar

Hoskin

2004

The Journal of Immunology

156

152

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“…Interestingly, Thy1.1 expression was almost completely shut down, while that of CD34 was maintained following KSHV infection. In differentiated cells, CD34 is often expressed in endothelial cells, while Thy1.1 is more confined to hematopoietic cells (22,23). Human Thy1 expression is associated with tumor suppression of ovarian cancer (24).…”

Section: Introductionmentioning

confidence: 99%

Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV

et al. 2012

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“…Expression of many of these markers on dermal fibroblasts has been previously reported. [15][16][17][18] Among these, known fibroblast markers such as CD90.2 (85.6%) and Sca-1 (75.9%) were expressed on significant fractions of isolated uncultured fibroblasts [19][20][21] (Table 1), validating the fidelity of our FACS sorting definition. Integrins or proteins that complex with integrins were prominent among markers with greater than 5% population positivity (CD9, CD29, CD47, CD54, CD61, CD104) ( Table 1) 10 We, therefore, harvested fibroblasts after 2 weeks in culture and processed them on the lyoplate panel according to the BD protocol.…”

Section: Differential Expression Of Multiple Surface Markers In Cultumentioning

confidence: 70%

Live Fibroblast Harvest Reveals Surface Marker Shift In Vitro

Walmsley

Rinkevich

et al. 2015

Tissue Engineering Part C: Methods

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Current methods for the isolation of fibroblasts require extended ex vivo manipulation in cell culture. As a consequence, prior studies investigating fibroblast biology may fail to adequately represent cellular phenotypes in vivo. To overcome this problem, we describe a detailed protocol for the isolation of fibroblasts from the dorsal dermis of adult mice that bypasses the need for cell culture, thereby preserving the physiological, transcriptional, and proteomic profiles of each cell. Using the described protocol we characterized the transcriptional programs and the surface expression of 176 CD markers in cultured versus uncultured fibroblasts. The differential expression patterns we observed highlight the importance of a live harvest for investigations of fibroblast biology.

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Thy-1: a lymphoid cell subset marker capable of delivering an activation signal to mouse T lymphocytes

Cited by 20 publications

References 56 publications

Thy-1: More than a Mouse Pan-T Cell Marker

Thy-1: More than a Mouse Pan-T Cell Marker

Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV

Live Fibroblast Harvest Reveals Surface Marker Shift In Vitro

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