Thunbergia mysorensis mediated nano silver oxide for enhanced antibacterial, antioxidant, anticancer potential and in vitro hemolysis evaluation

Kokila, N R; Mahesh, B.; Roopa, K.P.; Prasad, B. Daruka; Raj, Kalyan; Manjula, S; Mruthunjaya, K; Ramu, Ramith

doi:10.1016/j.molstruc.2022.132455

Cited by 22 publications

(11 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggests the presence of various functional groups responsible for the reduction of various metal ions to the NPS form. The FT-IR analysis suggested that the reasonable mechanism of metal-NPs formation may be due to the reduction of metal + ions that takes place together with oxidation of different bioactive compounds such as phenolic components of polyols or other reducing components in plant extract 1 , 23 . Also, Jacob et al .…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, Kokila et al . 1 that the observed antioxidant activity of AgNPs might be due to the existence of an assortment of phytochemicals like phenolics, flavonoids, and other active ingredients on the surface as capping agents on the NPs. AgNPs exhibited lower IC 50 values in the DPPH radical assay and better antioxidant activity than plant extracts due to their smaller size and stability.…”

Section: Resultsmentioning

confidence: 99%

“…Because of its multiple applications as optical probes, sensors, catalysts, antibacterial agents in healing wounds, burns, and surgery applications, the synthesis of NPs has gained significant attention from the scientific community. Plants are safe natural sources that possess varied concentrations of active agents that help promoting the reduction of metallic ions and, accordingly, stabilise the nanoparticles, hence the distinctiveness of the biologically produced nanoparticles 1 .…”

Section: Introductionmentioning

confidence: 99%

“…Cancer is a multi-factorial illness that stemmed from a complex fusion of environmental and hereditary determinants marked by unusual cell division. Besides, cancer is the second foremost instigator of death, which puts immense losses in the community 1 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Biological activities and antioxidant potential of different biosynthesized nanoparticles of Moringa oleifera

Shalaby

Shanab

El-Raheem

et al. 2022

Sci Rep

View full text Add to dashboard Cite

The science of nanotechnology is expanding daily and has the potential to benefit people. Moringa oleifera is an abundant source of phenolic compounds, which are bioactive substances. It is recognised as a necessary plant because of its medicinal potential and a wide variety of health benefits. The aim of the current study is to examine the antioxidant, antibacterial, and cytotoxicity effects of five nanoparticles (La2O3, CuO, Fe2O3, Ag, and ZnO) made using bioactive chemicals in the aqueous extract of Moringa oleifera leaves on four human cell lines (T47D, HepG2, A549, and Wi38). The UV–visible spectroscopy analysis with a surface plasmon peak in the 300–490 nm range and the value of the zeta potential of the various biosynthesized nanoparticles ranged from + 31 to + 37 mV, indicated the repulsion between the particles and the stability of the formulation nanoparticles confirmed the formation of all nanoparticles. Additionally, the DPPH method was used to assess the antioxidant activity of five distinct metal nanoparticles. The results show that this method works in parallel and is dependent on both the concentration of NPs and the incubation time. The anticancer effect of synthesized nanoparticles against four different cell lines has been tested. The cytotoxicity assay showed a dose-dependent and time-dependent effect of nanoparticles. The obtained results conclude that acceptable potency against T47D and A549 cell lines with IC50 ranged from 38 to 210 μg/mL and 26 to 115 μg/mL, respectively. However, HepG2 and Wi38 cell lines showed relatively higher resistance against all tested nanoparticles when compared with Doxorubicin. Moreover, the antibacterial results revealed that silver nanoparticles exhibited the highest antibacterial activity against both Enterococcus faecalis and Staphylococcus aureus. Nanoparticles' high therapeutic activity at low concentrations opens up new avenues for the development of novel therapeutic approaches against human pathogens.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biological activities and antioxidant potential of different biosynthesized nanoparticles of Moringa oleifera

Shalaby

Shanab

El-Raheem

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…An aqueous dispersion of Ag 2 ONPs produced by treating water with flashed electrical discharges effectively prevented tumor growth in in vivo. 154 The prolonged systemic influence of Ag 2 ONPs resulted in tumor growth regression in some cases, as demonstrated by histomorphological research. 155 …”

Section: Applications Of Metal‐based Nms In Different Types Of Cancermentioning

confidence: 94%

Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

Kumar

Shukla

Sharma

et al. 2023

MedComm

View full text Add to dashboard Cite

Cancer is a disease associated with complex pathology and one of the most prevalent and leading reasons for mortality in the world. Current chemotherapy has challenges with cytotoxicity, selectivity, multidrug resistance, and the formation of stemlike cells. Nanomaterials (NMs) have unique properties that make them useful for various diagnostic and therapeutic purposes in cancer research. NMs can be engineered to target cancer cells for early detection and can deliver drugs directly to cancer cells, reducing side effects and improving treatment efficacy. Several of NMs can also be used for photothermal therapy to destroy cancer cells or enhance immune response to cancer by delivering immune‐stimulating molecules to immune cells or modulating the tumor microenvironment. NMs are being modified to overcome issues, such as toxicity, lack of selectivity, increase drug capacity, and bioavailability, for a wide spectrum of cancer therapies. To improve targeted drug delivery using nano‐carriers, noteworthy research is required. Several metal‐based NMs have been studied with the expectation of finding a cure for cancer treatment. In this review, the current development and the potential of plant and metal‐based NMs with their effects on size and shape have been discussed along with their more effective usage in cancer diagnosis and treatment.

show abstract

Green Synthesis of Silver and Silver Oxide Nanoparticles From Plants and Their Characterization

Kandwal,

Parveen,

Bachheti

et al. 2024

Smart Nanomaterials Technology

View full text Add to dashboard Cite

Thunbergia mysorensis mediated nano silver oxide for enhanced antibacterial, antioxidant, anticancer potential and in vitro hemolysis evaluation

Cited by 22 publications

References 45 publications

Biological activities and antioxidant potential of different biosynthesized nanoparticles of Moringa oleifera

Biological activities and antioxidant potential of different biosynthesized nanoparticles of Moringa oleifera

Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

Green Synthesis of Silver and Silver Oxide Nanoparticles From Plants and Their Characterization

Contact Info

Product

Resources

About