Through thick and thin: a pictorial review of the endometrium

Caserta, Melanie P.; Bolan, Candice W.; Clingan, M. Jennings

doi:10.1007/s00261-016-0930-5

Cited by 15 publications

(3 citation statements)

References 44 publications

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“…Ultrasound is widely used to assess endometrium and there are different features for different phases of endometrium. [24] However, different phases of endometrium are mainly differentiated by endometrial thickness while this study shows OCTIS could demonstrate endometrial glands which could add information on the assessment of different phases of endometrium. In addition, the OCTIS machine used in our study can obtain real-time images without delay as it took 10 to 30 seconds for the endometrium evaluation in the above study [17] that render clinical use of OCTIS.…”

Section: Discussionmentioning

confidence: 73%

Endometrium imaging using real-time rotational optical coherence tomography imaging system

Law¹,

Wu²,

Xu³

et al. 2019

Medicine

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This study aimed to evaluate a novel real-time rotational optical coherence tomography (OCT) imaging system (OCTIS) with a fiberoptic probe to look at endometrium and to correlate the OCTIS images with standard histology. OCT could obtain real-time images resembling histological examination. With recent development of customized probes, it allows OCT to be used in the field of gynecology.This is a pilot, prospective, ex-vivo and observational study. Women underwent hysterectomy for various gynecological conditions were recruited and OCTIS images were obtained from endometrium of 15 fresh uterus specimens immediately after hysterectomy. The excised uterus was cut open and OCTIS imaging was obtained. The scanned region of endometrium was excised for histological examination and OCTIS images were precisely compared to corresponding histological images and ultrasound images. Blinded qualitative analysis on OCTIS images was performed by 2 assessors to determine inter-rating reliability on the histopathological diagnosis.Epithelium, glands, cysts, and stroma of endometrium were clearly seen by the OCTIS. Different phases of menstrual cycle of normal endometrium could be differentiated and pathological condition such as hyperplastic and dysplasic endometrium, which corresponded well with histological findings, could be identified. The inter-rater reliability between assessors on overall OCTIS endometrium and neoplastic OCTIS endometrium was moderate (Kendall tb of 0.58) and substantial (Kendall tb of 0.76), respectively.OCTIS can provide real-time, high-resolution and rotational imaging modality to view endometrial structure with high consistency with histological examination and satisfactory agreement between observers. It has a great potential to be developed in the clinical use of endometrial assessment for gynecological applications.

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Section: Discussionmentioning

confidence: 73%

Endometrium imaging using real-time rotational optical coherence tomography imaging system

Law¹,

Wu²,

Xu³

et al. 2019

Medicine

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“…The assessment of the endometrial condition is a critical component of routine gynecological examinations 1 . This includes evaluating its thickness, 2 texture, 3 and the presence of any intrauterine space-occupying lesions 4 . Consequently, the precise delineation of the endometrial area provides essential information for medical diagnosis, influencing the choice of treatment and its outcomes 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

Segment anything with inception module for automated segmentation of endometrium in ultrasound images

Qiu,

Xie,

Jiang

et al. 2024

J. Med. Imag.

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Accurate segmentation of the endometrium in ultrasound images is essential for gynecological diagnostics and treatment planning. Manual segmentation methods are time-consuming and subjective, prompting the exploration of automated solutions. We introduce "segment anything with inception module" (SAIM), a specialized adaptation of the segment anything model, tailored specifically for the segmentation of endometrium structures in ultrasound images.Approach: SAIM incorporates enhancements to the image encoder structure and integrates point prompts to guide the segmentation process. We utilized ultrasound images from patients undergoing hysteroscopic surgery in the gynecological department to train and evaluate the model.Results: Our study demonstrates SAIM's superior segmentation performance through quantitative and qualitative evaluations, surpassing existing automated methods. SAIM achieves a dice similarity coefficient of 76.31% and an intersection over union score of 63.71%, outperforming traditional task-specific deep learning models and other SAM-based foundation models. Conclusions:The proposed SAIM achieves high segmentation accuracy, providing high diagnostic precision and efficiency. Furthermore, it is potentially an efficient tool for junior medical professionals in education and diagnosis.

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“…Normal embryos and healthy uteri are two necessary factors for a successful pregnancy 1 . The recent, continuous increase in induced abortions, uterine cavity operations, and the functional defects in endometrial stem/progenitor cells are believed to be responsible for thinning endometrium (< 7 mm) 2 . It has been reported that the thin endometrium is a defect of endometrial development and is associated with low embryo implantation rates 3 – 6 .…”

Section: Introductionmentioning

confidence: 99%

Transplantation of umbilical cord-derived mesenchymal stem cells promotes the recovery of thin endometrium in rats

Zhang

Liu

Dong

et al. 2022

Sci Rep

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The endometrium plays a critical role in embryo implantation and pregnancy, and a thin uterus is recognized as a key factor in embryo implantation failure. Umbilical cord mesenchymal stem cells (UC-MSCs) have attracted interest for the repair of intrauterine adhesions. The current study investigated the repair of thin endometrium in rats using the UC-MSCs and the mechanisms involved. Rats were injected with 95% ethanol to establish a model of thin endometrium. The rats were randomly divided into normal, sham, model, and UC-MSCs groups. Endometrial morphological alterations were observed by hematoxylin–eosin staining and Masson staining, and functional restoration was assessed by testing embryo implantation. The interaction between UC-MSCs and rat endometrial stromal cells (ESCs) was evaluated using a transwell 3D model and immunocytochemistry. Microarray mRNA and miRNA platforms were used for miRNA-mRNA expression profiling. Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) analyses were performed to identify the biological processes, molecular functions, cellular components, and pathways of endometrial injury and UC-MSCs transplantation repair and real-time quantitative reverse transcription PCR (qRT-PCR) was performed to further identify the expression changes of key molecules in the pathways. Endometrium thickness, number of glands, and the embryo implantation numbers were improved, and the degree of fibrosis was significantly alleviated by UC-MSCs treatment in the rat model of thin endometrium. In vitro cell experiments showed that UC-MSCs migrated to injured ESCs and enhanced their proliferation. miRNA microarray chip results showed that expression of 45 miRNAs was downregulated in the injured endometrium and upregulated after UC-MSCs transplantation. Likewise, expression of 39 miRNAs was upregulated in the injured endometrium and downregulated after UC-MSCs transplantation. The miRNA-mRNA interactions showed the changes in the miRNA and mRNA network during the processes of endometrial injury and repair. GO and KEGG analyses showed that the process of endometrial injury was mainly attributed to the decomposition of the extracellular matrix (ECM), protein degradation and absorption, and accompanying inflammation. The process of UC-MSCs transplantation and repair were accompanied by the reconstruction of the ECM, regulation of chemokines and inflammation, and cell proliferation and apoptosis. The key molecules involved in ECM-receptor interaction pathways were further verified by qRT-PCR. Itga1 and Thbs expression decreased in the model group and increased by UC-MSCs transplantation, while Laminin and Collagen expression increased in both the model group and MSCs group, with greater expression observed in the latter. This study showed that UC-MSCs transplantation could promote recovery of thin endometrial morphology and function. Furthermore, it revealed the expression changes of miRNA and mRNA after endometrial injury and UC-MSCs transplantation repair processed, and signaling pathways that may be involved in endometrial injury and repair.

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Through thick and thin: a pictorial review of the endometrium

Cited by 15 publications

References 44 publications

Endometrium imaging using real-time rotational optical coherence tomography imaging system

Endometrium imaging using real-time rotational optical coherence tomography imaging system

Segment anything with inception module for automated segmentation of endometrium in ultrasound images

Transplantation of umbilical cord-derived mesenchymal stem cells promotes the recovery of thin endometrium in rats

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