Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study

Finlay, Malcolm; Mosse, Charles A.; Colchester, Richard J.; Noimark, Sacha; Zhang, Edward; Ourselin, Sébastien; Beard, Paul C.; Schilling, Richard J.; Parkin, Ivan P.; Papakonstantinou, Ioannis; Desjardins, Adrien E.

doi:10.1038/lsa.2017.103

Cited by 101 publications

(101 citation statements)

References 33 publications

(26 reference statements)

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“…Other recent papers related to high‐resolution imaging can be found elsewhere . Moreover, there is a significant progress in high‐resolution imaging based on photoacoustic transmitters.…”

Section: Photoacoustic Transmitters For Novel Applicationsmentioning

confidence: 99%

Efficient Photoacoustic Conversion in Optical Nanomaterials and Composites

Lee

Baac

et al. 2018

Advanced Optical Materials

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approaches. While addressing the limitations of the electrical counterparts (e.g., massive amounts of radio frequency (RF) cabling and electromagnetic (EM) interference), a photoacoustic approach for gene rat ing high-amplitude ultrasound has created new opportunities.Active research on efficient photo acoustic materials has started with the development of photoacoustic contrast mediums (e.g., exogenous contrast particles) for contrast enhancement. [3][4][5] Recent advances in nanofabrication technologies have allowed to develop more efficient photoacoustic contrast mediums, [3] such as metal nanoparticles having enhanced optical absorption due to optical resonance. Later, by coating such nanoparticles on a flat substrate, layered structures were developed for generating high-amplitude ultrasound. Among many nanoparticles, gold nanoparticles were widely used owing to strong resonance. [6] In fact, these initial efforts to increase photoacoustic conversion were focused on increasing light absorption, while the critical role of thermal expansion for photoacoustic generation were often overlooked.To enhance thermal expansion for photoacoustic generation, researchers have started to fabricate composite materials, composed of light-absorbing materials mixed with polymers with high thermal expansion coefficients. These polymer-based composites significantly enhance photoacoustic conversion efficiency. Among many polymers, polydimethylsiloxane (PDMS) is exclusively used because of its high thermal expansion, optical transparency, and acoustic impedance comparable to that of water. [7][8][9][10][11] Photoacoustic pulses generated with PDMSbased composites have the characteristics of high amplitude and high frequency, which have enabled interesting applications such as cavitation-based therapy [12] and imaging. [13] For photoacoustic composites, there are a myriad of light-absorbing nanomaterials such as metal absorbers [6] and carbon nanomaterials (e.g., carbon black (CB), [14] carbon nanotube (CNT), [7,10] carbon nanofiber (CNF), [9] candle soot (CS), [8] and reduced graphene oxide (rGO) [15] ). These light-absorbing materials of nanometer sizes have an advantage over microscale absorbing materials [7] in facilitating heat transfer from the light absorbers into the surrounding mediums. Such facilitated heat transfer is another key factor that contributes to photoacoustic energy conversion.In this Review, we will start with general considerations of photoacoustic generation in nanomaterial composites. Various photoacoustic composites enabling interesting applications will be introduced. In addition, recent efforts will be reviewed from an application perspective. Also, we will discuss outlook and future directions.Photoacoustic pulses generated by pulsed laser irradiation have the characteristics of high frequency and wide bandwidth, which are desirable for imaging and sensing. Efficient photoacoustic composites have been developed for fabricating photoacoustic transmitters capable of generating highamplitude ultrasound....

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Section: Photoacoustic Transmitters For Novel Applicationsmentioning

confidence: 99%

Efficient Photoacoustic Conversion in Optical Nanomaterials and Composites

Lee

Baac

et al. 2018

Advanced Optical Materials

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“…60 µm. 4 The acquired ultrasound A-lines were band-pass filtered (Butterworth, 4 th order, 3 − 25 MHz) to reduce the noise, prior to cross-talk removal. 3 Subsequently the signal envelope was found using a Hilbert transform and then a log transform was applied for display.…”

Section: All-optical Ultrasound Probementioning

confidence: 99%

“…2,5 In a recent study one such device was integrated into a needle to provide real-time M-mode imaging during an in vivo experiment. 4 Further, real-time rotational imaging using optical fibres has been demonstrated on ex vivo swine carotid arteries. 6 Additionally, the combination of all-optical robotics has demonstrated the potential for its use to provide feedback and improve robotic control.…”

Section: Introductionmentioning

confidence: 99%

“…2 These optical methods can provide high sensitivity and broad ultrasound bandwidths, as well as immunity to electromagnetic interference. 3,4 The use of optical fibres in OpUS probes has enabled highly miniaturised ultrasound imaging devices capable of 2D 3 and 3D imaging. 2,5 In a recent study one such device was integrated into a needle to provide real-time M-mode imaging during an in vivo experiment.…”

Section: Introductionmentioning

confidence: 99%

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Large area all-optical ultrasound imaging using robotic control

Colchester¹,

Alles²,

Dwyer³

et al. 2019

Opto-Acoustic Methods and Applications in Biophotonics IV

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In this study we report the integration of an all-optical ultrasound probe and robotic manipulator. The alloptical ultrasound probe comprised two optical fibres, a MWCNT/PDMS composite coated multimode fibre for ultrasound generation, and a concave Fabry-Pérot fibre optic hydrophone for ultrasound reception. The ultrasound probe generated pressures in excess of 2 MPa at 1.5 mm, with a corresponding −6 dB bandwidth of ca. 30 MHz. The probe was built into a rigid endoscope (outer diameter: 5 mm, length: 300 mm) and mounted on a robotic manipulator. Ultrasound A-lines were acquired during robot manipulation in order to reconstruct a 3D image which was displayed as a point cloud. Large area images (80 × 80 mm) of a tissue mimicking gel wax phantom where acquired and displayed in real-time. This work demonstrates the potential for integrating miniature fibre optic ultrasound devices with robotics.

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“…The combined PA/US imaging system achieved 30 frames (2.8 × 2.8 cm) per second. Another approach to needle guidance is integrating the PA generator and ultrasound sensor into the needle tip [116][117][118]. In [117], the needle contained three fibers.…”

Section: Combined Pa and Lu Pulse-echo Imagingmentioning

confidence: 99%

The Progress in Photoacoustic and Laser Ultrasonic Tomographic Imaging for Biomedicine and Industry: A Review

et al. 2018

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The current paper reviews a set of principles and applications of photoacoustic and laser ultrasonic imaging, developed in the Laser Optoacoustic Laboratories of ILIT RAS, NUST MISiS, and ILC MSU. These applications include combined photoacoustic and laser ultrasonic imaging for biological objects, and tomographic laser ultrasonic imaging of solids. Principles, algorithms, resolution of the developed methods, and related problems are discussed. The review is written in context of the current state-of-art of photoacoustic and laser ultrasonic imaging.

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Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study

Cited by 101 publications

References 33 publications

Efficient Photoacoustic Conversion in Optical Nanomaterials and Composites

Efficient Photoacoustic Conversion in Optical Nanomaterials and Composites

Large area all-optical ultrasound imaging using robotic control

The Progress in Photoacoustic and Laser Ultrasonic Tomographic Imaging for Biomedicine and Industry: A Review

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