The current paper reviews a set of principles and applications of photoacoustic and laser ultrasonic imaging, developed in the Laser Optoacoustic Laboratories of ILIT RAS, NUST MISiS, and ILC MSU. These applications include combined photoacoustic and laser ultrasonic imaging for biological objects, and tomographic laser ultrasonic imaging of solids. Principles, algorithms, resolution of the developed methods, and related problems are discussed. The review is written in context of the current state-of-art of photoacoustic and laser ultrasonic imaging.
We consider laser printing of gel microdroplets – a promising method for microbiology, biotechnology and medicine. In the printing process, small volumes of gel containing living microorganisms are transferred as a result of cavitation caused by the absorption of a short laser pulse in a metal film. However, in such a transfer, certain physical factors arise that can lead to damage and death of biological material. These factors include elevated temperature and pressure, high radiation intensity and some others. Experimental estimates of these parameters are conducted, based on measurements of the acoustic response of laser printing, electron microscopy of the affected areas and the results of high-speed imaging of the transfer process. It is shown that these factors are not a significant limitation for the technology being developed. Laser printing is performed by exposing a metal film to laser pulses with an energy of 5 – 30 μJ and a duration of 8 – 14 ns, the laser beam diameter being 30 μm.
We describe a universal system for research in combined real-time optoacoustic (OA) and laser-ultrasonic (LU) imaging. The results of its testing on the task of needle insertion into the blood vessel model diagnostics are presented. In OA mode, where laser light is absorbed directly in the sample, the contents of blood vessel model is clearly visible. In LU mode, where the short ultrasonic probe pulse scattered on the sample is detected, the needle is clearly visible. The developed solution combining OA and LU imaging modalities due to the common detection system allowed real-time diagnostics of the position of medical needles (0.63 mm and 0.7 mm in diameter) inside blood vessel models (1.6 mm and 2.4 mm in diameter). Frame rate was 10 Hz. High longitudinal spatial resolution of the system − 0.1 mm − allows distinguishing the two walls of the vessel model and the position of the needle inside.
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