1995
DOI: 10.1097/00002480-199541020-00009
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Thromboxane B2 Blood Levels and Incipient System Clotting in Heparin Free Hemodialysis

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Cited by 13 publications
(6 citation statements)
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“…The process of HD is associated with increased thromboxane production [28]. However, this does not happen in sham dialysis in healthy subjects in spite of complement activation and marked leukopenia, indicating the presence of other factors in ESRD patients [45] which may increase the sensitivity of pulmonary vessels to thromboxane.…”
Section: Discussionmentioning
confidence: 99%
“…The process of HD is associated with increased thromboxane production [28]. However, this does not happen in sham dialysis in healthy subjects in spite of complement activation and marked leukopenia, indicating the presence of other factors in ESRD patients [45] which may increase the sensitivity of pulmonary vessels to thromboxane.…”
Section: Discussionmentioning
confidence: 99%
“…In this study, we have selected an EIA‐based method for direct TxB 2 (11‐dTxB 2 ) measurement, because it is still one of the most accessible and suitable methods for the monitoring of the effect of ASA and aspirin response in ASA‐treated patients . It is widely known that in healthy donors, the plasma concentrations of TxB 2 (11‐dTxB 2 ) are relatively low (1–2 pg/mL TxB 2 ) . ASA treatment dependently of the used dose (100 mg per day is sufficient in 90% of patients to reach the selective cumulative inhibitory effect in low‐dose ASA‐treated patients – data not shown) leads to almost 95% reduction in TxB 2 (11‐dTxB 2 ) production .…”
Section: Discussionmentioning
confidence: 99%
“…These measurements lead us to an interesting observation that trisodium citrate–treated plasma gives concentrations of TxB 2 (11‐dTxB 2 ) comparable to those obtained in serum (Figures a,b and a,b). It is known that higher serum values of TxB 2 (32–64 pg/mL) are attributed to platelet activation, and thus, the ex vivo determination of TxB 2 reflects a maximal capacity of activated platelets to synthesize Tx via COX‐1 pathway – and it is a most sensitive measure of aspirin response; . It was also shown that Tx production does not necessarily correlate with aggregation – this is multifactorial .…”
Section: Discussionmentioning
confidence: 99%
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“…Besides conventional cardiovascular risk factors including diabetes, hypertension, hyperlipidemia, secondary hyperparathyroidism, hypoalbuminemia, smoking, and sedentary lifestyle, increasing attention has also been paid to the role of hemostatic factors. The regular contact of blood with bioincompatible dialyzer membranes induces platelet activation [5], plasma coagulation [6], and alterations in the physiologic inhibitors of coagulation. Over the past decade, there has been steady, albeit sluggish, progress in the understanding of the impact of chronic hemodialysis on endogenous plasma coagulation inhibitors.…”
Section: Introductionmentioning
confidence: 99%