Thrombotic thrombocytopenic purpura developing during pregnancy in A C2‐deficient patient with a history of systemic lupus erythematosus

A case of thrombocytopoenic thrombotic purpura preceding onset of systemic lupus erythematosus

“…It may be suspected from an overall consideration of the findings that some points of contact exist between the two pathologies. In agreement with other authors [1,2,3] we note that central nervous system (CNS) symptoms were present in both attacks. The cited authors suggest, on the basis of the chronological relationship, that there may be a common etiology which probably depends on a factor present in the host.…”

The complement system and adverse pregnancy outcomes

“…Deficiencies in C1, C2, and C4 may predispose to collagen vascular disease and systemic lupus erythematosus (SLE) (Aggarwal et al, 2010; Jonsson et al, 2007; Meyer et al, 1985). Descriptions in pregnancy are limited to case reports or familial clusters of heterozygous carriers (Dantant et al, 1978; Dixit et al, 1985; Sullivan and Winkelstein, 1994). In light of the critical position of C3 in the complement cascade, inherited deficiency of this component results in overwhelming infections at an early age and no cases of human pregnancy have been reported in the literature among women with inherited C3 deficiency.…”

Book Review: Systemic lupus erythematosus and thrombotic thrombocytopenic purpura. Report of three cases and review of the literature

“…One C2 de®cient woman affected by SLE, in which TTP developed during pregnancy, showed remission of TTP after a ther- apeutic abortion. 13 One patient died before the beginning of any treatment 20 ( Table 2). The survival of TTP in SLE patients seems to be determined not by the activity of SLE, but above all by treatment choices; the use of either plasma exchange or plasma infusion signi®cantly reduces mortality.…”