A case of thrombocytopoenic thrombotic purpura preceding onset of systemic lupus erythematosus

Pietro, Giulia Di; Menicucci, A; Venturini, Sergio; Avanzi, G

doi:10.1002/(sici)1098-1101(1996)11:1<51::aid-jca12>3.0.co;2-#

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…Furthermore, in view of the high prevalence of aPL in patients with SLE (38±50%) (3), it would be expected that a similar proportion of SLE patients who develop TTP to test positive for aPL without necessarily implying an existing causal relationship. Although only a handful of patients (similar to Case 2) have been reported in whom TTP preceded the development of SLE (12), this may become more common than previously noted due to the better survival of TTP patients since the introduction of PE. It is likely that a diverse number of factors lead to and initiate this process of MVEC apoptosis, and aPL may well be one of these.…”

Section: Discussionmentioning

confidence: 80%

Fulminant thrombotic thrombocytopenic purpura in two patients with systemiclupus erythematosus and phospholipid autoantibodies

Musa¹,

Nounou

Sahovic³

et al. 2000

European J of Haematology

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Section: Discussionmentioning

confidence: 80%

Fulminant thrombotic thrombocytopenic purpura in two patients with systemiclupus erythematosus and phospholipid autoantibodies

Musa¹,

Nounou

Sahovic³

et al. 2000

European J of Haematology

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“…7 TTP with SS is rare. Individual cases of TTP preceding the diagnosis of SS, 8 SLE,9 or systemic sclerosis 10 have been reported. These reports contain the suggestion that in some cases the cause of TTP may be related to an autoimmune mechanism.…”

Section: Discussionmentioning

confidence: 99%

Thrombotic thrombocytopenic purpura complicating Sj�gren?s syndrome with crescentic glomerulonephritis and membranous nephritis

et al. 2004

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The association of either thrombotic thrombocytopenic purpura (TTP) or crescentic glomerulonephritis with Sjögren's syndrome is rare. We report a case of TTP appearing after the diagnosis of SjOgren's syndrome with crescentic glomerulonephritis and membranous nephropathy. Circulating immune complex was detected, and immune complex deposits were shown along the capillary walls of renal biopsy specimens. Despite steroid pulse therapy and plasma exchange therapy, the patient died. The etiology of TTP is unclear. This case is important when considering the etiology of TTP related to autoimmune disease.

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Thrombotic Thrombocytopenic Purpura as an Initial Presentation of Primary Sjo¨gren’s Syndrome

2002

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A healthy woman presented with ecchymoses due to thrombocytopenia, with numerous bone marrow megakaryocytes, microangiopathic haemolytic anaemia, disorientation, irritability, and normal renal function. Thrombotic thrombocytopenic purpura (TTP) was diagnosed and treated successfully by plasma exchange therapy, both on presentation and during a further three relapses. The TTP was considered idiopathic until, 4 months later, definite primary Sjogren's syndrome (1 degree SS) was diagnosed following the appearance of sicca symptoms. Only four similar cases have been cited in the literature. TTP should be added to the varied haematological manifestations that may occur in patients with 1 degree SS. The possible presentation of 1 degree SS not with classic sicca symptoms but rather with haematological abnormalities, including TTP, should be recognised.

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A case of thrombocytopoenic thrombotic purpura preceding onset of systemic lupus erythematosus

Cited by 4 publications

References 2 publications

Fulminant thrombotic thrombocytopenic purpura in two patients with systemiclupus erythematosus and phospholipid autoantibodies

Fulminant thrombotic thrombocytopenic purpura in two patients with systemiclupus erythematosus and phospholipid autoantibodies

Thrombotic thrombocytopenic purpura complicating Sj�gren?s syndrome with crescentic glomerulonephritis and membranous nephritis

Thrombotic Thrombocytopenic Purpura as an Initial Presentation of Primary Sjo¨gren’s Syndrome

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