Thrombospondin-1 in Early Flow-Related Remodeling of Mesenteric Arteries from Young Normotensive and Spontaneously Hypertensive Rats

Lemkens, Pieter; Boari, Gianluca E.M.; Fazzi, G. E.; Janssen, G.; Murphy-Ullrich, JE; Schiffers, Pmh; Mey, Jgr De

doi:10.2174/1874192401206010050

Cited by 7 publications

(3 citation statements)

References 48 publications

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“…6,16,18 Increased TSP-1 levels have also been noted in patients 16 and rats with hypertension. 24 Studies have also reported that TSP-1 may represent a link between vascular risk factors and vascular atherosclerotic lesion development . 17,25 Hypertension is a major driving force and a modifiable risk factor for atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Thrombospondin-1 associated with carotid intima–media thickness among individuals with hypertension

Lin,

Wu,

Chen

et al. 2024

Journal of Investigative Medicine

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In vivo and in vitro studies have demonstrated that thrombospondin-1 (TSP-1) is involved in atherosclerotic pathogenesis. However, the role of TSP-1 in clinical atherosclerosis remains unknown. This cross-sectional study investigated the relationship between TSP-1 and carotid intima–media thickness (IMT) and examined whether it interacts with conventional cardiovascular risk factors. A total of 587 participants were enrolled from February 2018 to December 2021. TSP-1 was dichotomized based on median value. Carotid IMT was measured bilaterally in each segment, and the average value was taken as the overall IMT variable. Analysis of covariance models were used to ascertain the main and interaction effects of cardiovascular risk factors and circulating TSP-1 levels on carotid IMT. Those with high TSP-1 (n = 294) had significantly higher carotid IMT than did those with low TSP-1 (n = 293; 0.74 ± 0.12 vs. 0.72 ± 0.11 mm; p = 0.011). After the combined effects of TSP-1 and vascular risk factors on carotid IMT were evaluated, an interaction effect on IMT was observed between TSP-1 and hypertension (adjusted F = 8.760; p = 0.003). Stratification analysis revealed that individuals with hypertension and high TSP-1 had significantly higher IMT than did those with low TSP-1 (adjusted p = 0.007). However, this difference was not observed in normotensive individuals (adjusted p = 0.636). In conclusion, this is the first study to provide clinical data supporting the correlation between TSP-1 and atherosclerosis. TSP-1 may be a crucial marker of increased susceptibility to atherosclerosis in individuals with hypertension.

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Section: Discussionmentioning

confidence: 99%

Thrombospondin-1 associated with carotid intima–media thickness among individuals with hypertension

Lin,

Wu,

Chen

et al. 2024

Journal of Investigative Medicine

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“…In the balloon catheter injury rat model, TSP was markedly increased in the thickening arterial wall, and the TSP antigen in thickening arterial wall is primary secreted by VSMcs (118). In rat resistance arteries, TSP-1 was able to reverse the pathological inward remodeling caused by spontaneous hypertension, indicating that TSP-1 may act as an inhibitor of arterial restenosis (119). A previous study identified that the interaction of TSP-1 and β1 integrin is associated with platelet-stimulated SMc proliferation (120).…”

Section: Arterial Restenosismentioning

confidence: 95%

Role of thrombospondin‑1 and thrombospondin‑2 in cardiovascular diseases (Review)

Zhang

et al. 2020

Int J Mol Med

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Thrombospondin (TSP)-1 and TSP-2 are matricellular proteins in the extracellular matrix (EcM), which serve a significant role in the pathological processes of various cardiovascular diseases (cVds). The multiple effects of TSP-1 and TSP-2 are due to their ability to interact with various ligands, such as structural components of the EcM, cytokines, cellular receptors, growth factors, proteases and other stromal cell proteins. TSP-1 and TSP-2 regulate the structure and activity of the aforementioned ligands by interacting directly or indirectly with them, thereby regulating the activity of different types of cells in response to environmental stimuli. The pathological processes of numerous cVds are associated with the degradation and remodeling of EcM components, and with cell migration, dysfunction and apoptosis, which may be regulated by TSP-1 and TSP-2 through different mechanisms. Therefore, investigating the role of TSP-1 and TSP-2 in different cVds and the potential signaling pathways they are associated with may provide a new perspective on potential therapies for the treatment of cVds. In the present review, the current understanding of the roles TSP-1 and TSP-2 serve in various cVds were summarized. In addition, the interacting ligands and the potential pathways associated with these thrombospondins in cVds are also discussed.

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“…Thrombospondin-1 (TSP-1) is involved in structural remodeling in large and small arteries [ 129 , 130 ]. Physiological levels of TSP-1 increased Superoxide production and decreased NO-dependent vasodilation more in coronary arterioles from old female rats than in young females [ 131 ].…”

Section: Potential Molecular Mechanisms In Age-dependent Structural R...mentioning

confidence: 99%

Functional, Structural and Proteomic Effects of Ageing in Resistance Arteries

Jensen

2024

IJMS

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The normal ageing process affects resistance arteries, leading to various functional and structural changes. Systolic hypertension is a common occurrence in human ageing, and it is associated with large artery stiffening, heightened pulsatility, small artery remodeling, and damage to critical microvascular structures. Starting from young adulthood, a progressive elevation in the mean arterial pressure is evidenced by clinical and epidemiological data as well as findings from animal models. The myogenic response, a protective mechanism for the microcirculation, may face disruptions during ageing. The dysregulation of calcium entry channels (L-type, T-type, and TRP channels), dysfunction in intracellular calcium storage and extrusion mechanisms, altered expression of potassium channels, and a change in smooth muscle calcium sensitization may contribute to the age-related dysregulation of myogenic tone. Flow-mediated vasodilation, a hallmark of endothelial function, is compromised in ageing. This endothelial dysfunction is related to increased oxidative stress, lower nitric oxide bioavailability, and a low-grade inflammatory response, further exacerbating vascular dysfunction. Resistance artery remodeling in ageing emerges as a hypertrophic response of the vessel wall that is typically observed in conjunction with outward remodeling (in normotension), or as inward hypertrophic remodeling (in hypertension). The remodeling process involves oxidative stress, inflammation, reorganization of actin cytoskeletal components, and extracellular matrix fiber proteins. Reactive oxygen species (ROS) signaling and chronic low-grade inflammation play substantial roles in age-related vascular dysfunction. Due to its role in the regulation of vascular tone and structural proteins, the RhoA/Rho-kinase pathway is an important target in age-related vascular dysfunction and diseases. Understanding the intricate interplay of these factors is crucial for developing targeted interventions to mitigate the consequences of ageing on resistance arteries and enhance the overall vascular health.

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Thrombospondin-1 in Early Flow-Related Remodeling of Mesenteric Arteries from Young Normotensive and Spontaneously Hypertensive Rats

Cited by 7 publications

References 48 publications

Thrombospondin-1 associated with carotid intima–media thickness among individuals with hypertension

Thrombospondin-1 associated with carotid intima–media thickness among individuals with hypertension

Role of thrombospondin‑1 and thrombospondin‑2 in cardiovascular diseases (Review)

Functional, Structural and Proteomic Effects of Ageing in Resistance Arteries

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