Thrombosis in Children (Clinical Cases)

Otto, N.Yu.; Sagitova, G.R.; Ledyaev, M.Ya.; Garyanin, R.V.; Ishchenko, E.M.; Shtepo, M.; Shouldis, V.A.; », Sbih Ar «Children's city polyclinic No

doi:10.19163/1994-9480-2020-2(74)-182-184

Journal of Volgograd State Medical University

2020

DOI: 10.19163/1994-9480-2020-2(74)-182-184

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Thrombosis in Children (Clinical Cases)

N.Yu. Otto¹,

G.R. Sagitova²,

M.Ya. Ledyaev³

et al.

Abstract: We have to state that «adult» diseases are increasingly common in children. In the article, the team of authors describes the clinical cases of thrombosis in children: the difficulties of verifying the diagnosis, justifying the therapy, and the tacticsof the doctor's action.

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Comprehensive Approach to Developing Baseline Reference Ranges for Platelet Function

et al. 2023

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Background. Thrombocytopathies are topical issues of pediatrics. Platelet dysfunction clinically manifests as thrombotic and hemorrhagic events of various severity and location. Platelet function can be evaluated via aggregatometry. Specified parameters for aggregatometry can be used in pediatrics as a standard for evaluating platelet function in peripheral blood. There were no similar studies in children in Russian Federation.Objective. The aim of the study is — to justify the significance of reference ranges (RR) development for platelet aggregatometry in pediatrics.Methods. The study included 30 relatively healthy patients aged from 1 to 18 years. Laboratory tests included complete blood count via automatic hematological analyzer; platelet aggregation in whole blood was evaluated via impedance aggregometer; plasmic hemostasis component (Quick prothrombin), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen were evaluated on automatic coagulation analyzer; molecular genetic study of platelet genes polymorphisms was performed via real-time PCR. Several inducers were used to study platelet aggregation: thrombin receptor activating peptide (TRAP), adenosine diphosphate (ADP), arachidonic acid (ASPI). Instrumental methods included electrocardiography, ultrasound of abdomen, urinary system, and thyroid gland.Results. The study included 16 girls and 14 boys. The median age was 9.4, interquartile range (IQR) was 6.5; 14,1. RR for platelet aggregation indicators were determined for all aggregation inducers (thrombin, ADP, arachidonic acid) as a result of the study.Conclusion. The obtained data will allow to improve the diagnosis approach for platelet dysfunction regarding the established reference ranges. The results of further research may contribute in the development of the algorithm for controlling antiplatelet therapy in patients with contraindications or with genetically determined low sensitivity to thrombocyte aggregation inhibitors based on acetylsalicylic acid.

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Comprehensive Approach to Developing Baseline Reference Ranges for Platelet Function

et al. 2023

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Extended necrotic intestinal lesions in a 12-year-old child with thrombophilia

Гаймоленко

Kashafeeva

Mazin

et al. 2022

Russian Journal of Pediatric Surgery

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Introduction. The hereditary tendency to thrombosis in children has been studied for the past 20 years due to molecular genetics. Currently, about 40 point mutations are known.Purpose. The article presents a clinical case taken from the authors’ practice which demonstrates thrombophilia complications in a child.Material and methods. A 12-year old girl was admitted to the registration department of the Regional Children’s Clinical Hospital (Chita) with abdominal pain and multiple vomitings. The complete blood count (CBC) revealed a marked hemoconcentration. Thrombophilia was diagnosed before the patients was hospitalized.Results. The performed surgical treatment was made by stages because of the extended necrotic lesion of the intestine. The testing of genetic polymorphism associated with thrombophilia risks revealed risk alleles FGB*455GA in the patientConclusion. The given article describes specific manifestations of gastrointestinal tract lesion, difficulties in diagnostics and care of complications in a patient with thrombophilia.

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Thrombosis in Children (Clinical Cases)

Abstract: We have to state that «adult» diseases are increasingly common in children. In the article, the team of authors describes the clinical cases of thrombosis in children: the difficulties of verifying the diagnosis, justifying the therapy, and the tacticsof the doctor's action.

Cited by 2 publications

References 1 publication

Comprehensive Approach to Developing Baseline Reference Ranges for Platelet Function

Comprehensive Approach to Developing Baseline Reference Ranges for Platelet Function

Extended necrotic intestinal lesions in a 12-year-old child with thrombophilia

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