Extended necrotic intestinal lesions in a 12-year-old child with thrombophilia

Abstract

Introduction. The hereditary tendency to thrombosis in children has been studied for the past 20 years due to molecular genetics. Currently, about 40 point mutations are known.Purpose. The article presents a clinical case taken from the authors’ practice which demonstrates thrombophilia complications in a child.Material and methods. A 12-year old girl was admitted to the registration department of the Regional Children’s Clinical Hospital (Chita) with abdominal pain and multiple vomitings. The complete blood count (CBC) revealed a marked hemoconcentration. Thrombophilia was diagnosed before the patients was hospitalized.Results. The performed surgical treatment was made by stages because of the extended necrotic lesion of the intestine. The testing of genetic polymorphism associated with thrombophilia risks revealed risk alleles FGB*455GA in the patientConclusion. The given article describes specific manifestations of gastrointestinal tract lesion, difficulties in diagnostics and care of complications in a patient with thrombophilia.