Thrombosis and hemostasis health in pregnancy: Registries from the International Society on Thrombosis and Haemostasis

Abstract

Online patient registries are used to collect data on clinical conditions with rare occurrence or unclear diagnostic and management practices. The success of these registries depends on clear definition of goals, correct identification of patient population/inclusion criteria, availability of appropriate setup and maintenance tools, and the quality of dissemination. The Scientific and Standardization Committee (SSC) for Women's Health Issues in Thrombosis and Hemostasis, one of 20 committees of the International Society on Thrombosis and Haemostasis (ISTH) has developed 6 registries for women's bleeding and thrombotic conditions over the past 2 years and are currently in various stages of progress. Here, we provide information about these registries, including rationale, objectives, and methods for data collection. The aim is to enhance worldwide participation and thus promote the success of these registries. We used ISTH REDCap, a mature and secure Web application for building and managing online surveys and databases, and the ISTH advertising platform to maximize participation. Registries (links and project details available on ISTH and Women's SSC Web sites) include: (1) WiTEAM, project on thrombophilia and placenta‐mediated obstetric complications; (2) a registry for disseminated intravascular coagulation in pregnancy; (3) severe congenital protein C deficiency—an obstetric study; (4) obstetric and gynecologic outcomes of women with platelet function disorders; (5) thrombolysis and invasive treatments for massive pregnancy‐related pulmonary embolism; (6) pregnancy and exposure to direct oral anticoagulants. The ISTH promotes online registries on women's issues to enhance understanding of current practices, identify knowledge gaps, promote research, and ultimately improve patient safety and quality of life.

Proteomics Studies in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

“…Coagulation factors are blood proteins that are involved in hemostasis. During pregnancy, the concentrations of F5, F7, F8, F9, F10, F12 and von Willebrand factor increase significantly together with an increase in the concentration of plasma fibrinogen [ 78 ]. This helps blood clot more easily during pregnancy to reduce blood loss during labor and delivery [ 79 ].…”

Pulmonary Embolism and Pregnancy—Challenges in Diagnostic and Therapeutic Decisions in High-Risk Patients

“…Overall, the evidence for advanced treatment options in high-risk PE during pregnancy is poor. A prospective international registry investigating the effectiveness and safety of advanced methods in massive pregnancy-related PE is currently underway (MAPP registry endorsed by the International Society on Thrombosis and Haemostasis) ( 53 ). Due to the diagnostic and treatment complexity, a multidisciplinary team (with experience in PE management in pregnancy) should be consulted to evaluate the best and treatment approach ( 7 ).…”

Immunological and physiopathological approach of COVID-19 in pregnancy

“…Thus, manifestations can be either thrombotic or haemorrhagic. Venous and arterial thrombosis have been reported in both COVID-19 patients [ 100 – 102 ], and pregnant women [ 103 ]. Coagulopathy complications, thrombosis apart, have been reported similarly in pregnant women and in the general population [ 104 ]; however, pregnant women deserve closer surveillance since they are more likely to suffer from thrombotic-haemorrhagic catastrophic events [ 97 , 98 ].…”