Thrombophilic alterations, migraine, and vascular disease: results from a case-control study

Cavestro, Cinzia; Degan, Diana; Micca, Gianmatteo; Aloi, Raffaele; Mandrino, Silvia; Frigeri, Maria Cristina; Pistoia, Francesca; Molinari, Filippo; Sacco, Simona

doi:10.1007/s10072-020-05006-z

Cited by 7 publications

(4 citation statements)

References 43 publications

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“…15 16 In the examination of the thrombophilia screening, thrombophilia disorder was detected in 34.8% of MA patients. In a similar study 6 evaluating migraines with and without aura, the rate of thrombophilia was found to be of 32.5%. In another study 15 conducted on female patients with MA, the rate of patients with thrombophilia was found to be of 46%; the reason for the high rate in this study may be that FVL and factor II G20210A (FIIL) mutations were also examined.…”

Section: Discussionmentioning

confidence: 79%

“…New information has shown that there is a significant relationship between antiphospholipid syndrome (APS) and migraine, and that protein S (PS) deficiency is five times more common in migraine patients than in healthy controls. 6 The most common characteristic of genetic or acquired thrombophilia is the increased risk of developing thrombosis. 7,8 The most prominent genetic variants include factor V Leiden (FVL) mutation, antithrombin 3 (AT III) activity, protein C (PC) and PS deficiency, thrombophilia associated with prothrombin, and active protein C (APC) resistance.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the relationship between thrombophilic disorders and brain white matter lesions in migraine with aura

Yılmaz Can

2024

Arq Neuropsiquiatr

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Background Migraine is associated with several genetic or acquired comorbidities. Studies conducted in recent years emphasize that the frequency of thrombophilia is high in migraine, especially migraine with aura (MA). Similarly, the presence of white matter lesions (WMLs) on brain magnetic resonance imaging (MRI) scans has been associated with migraine for many years. Objective Based on the knowledge that both WMLs and thrombophilia variants are frequently observed in MA, we aimed to investigate whether there is a relationship between genetic thrombophilia and the presence of WMLs in these patients. Methods The levels of proteins S and C, antithrombin III activities, activated protein C (APC) resistance, antiphospholipid immunoglobulin G/immunoglobulin M (IgG/IgM) and anticardiolipin IgG/IgM antibodies were investigated in 66 MA patients between the ages of 18 and 49 years who presented no cardiovascular risk factors. The presence of WMLs and the Fazekas grade was determined from the brain magnetic resonance imaging (MRI) scans' T2-weighted and fluid-attenuated inversion recovery (FLAIR) sequence taken from the patients. The rates of WMLs were compared in patients with and without thrombophilia. Results Thrombophilia was detected in 34.8% of the patients, and 27.3% were determined to have WMLs in brain MRI scans. The WMLs were detected in 23.3% of the patients without thrombophilia, in 34.8% of those with thrombophilia, and in 50% of the subjects with multiple thrombophilia disorders. Among the thrombophilia disorders, only APC resistance was significantly more common in patients with WMLs. Conclusion The results of the present study showed that thrombophilia may be a mechanism that should be investigated in the etiology of increased WMLs in MA.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Investigation of the relationship between thrombophilic disorders and brain white matter lesions in migraine with aura

Yılmaz Can

2024

Arq Neuropsiquiatr

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“…Research into the genes involved in both types has provided insights into the role of both neural and vascular pathways (Sutherland et al 2019). Numerous studies have also indicated that migraineurs have an increased risk of vascular diseases (Cavestro et al 2021). For example, an association between migraine and ischemic stroke was earliest recognized (Øie et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural imaging reveals vascular remodeling in migraine patients

Cortese

Tagliatti

Gagliani

et al. 2022

Histochem Cell Biol

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Migraine is a neurological disorder and one of the most common pain conditions worldwide. Despite its prevalence, the basic biology and underlying mechanisms contributing to the development of migraine are still poorly understood. It is still unclear, for instance, whether the vasculature, both extra and intracranial, plays a significant role in the generation of migraine pain. Neuroimaging data, indeed, have reported conflicting results on blood vessels abnormalities like vasodilation, while functional studies suggest that vessels dysfunction may extend beyond vasodilation. Here we combined light and electron microscopy imaging to investigate the fine structure of superficial temporal (STA) and occipital arteries (OA) from patients that underwent minimally invasive surgery for migraine. Using optical microscopy, we observed that both STA and OA vessels showed marked endothelial thickening and internal elastic lamina fragmentation. In the muscular layer, we found profound shape changes of vascular smooth muscle cells (VSMCs), abundant extracellular matrix, and the presence of clear extracellular vacuoles. The electron microscopy analysis confirmed putative VSMCs infiltrated within the intima layer and revealed a consistent shifting of VSMCs from contractile to a synthetically active phenotype. We also report the presence of (i) abundant extracellular vacuoles filled with fine granular material and membranes, (ii) multilamellar structures, (iii) endosome-like organelles, and (iv) bona fide extracellular vesicles in the matrix space surrounding synthetically active cells. As both the endothelial layer and VSMCs coordinate a variety of vascular functions, these results suggest that a significant vascular remodeling is occurring in STA and OA of migraine patients. Thus, this phenomenon may represent an important target for future investigation designed toward the development of new therapeutic approaches.

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“…In the literature, there are many studies that have evaluated patients with headache using a case–control design. Most of these studies relied on patients from hospitals or migraine centers [ 29 , 30 , 31 , 32 , 33 , 34 ]. Other studies looked at national or regional databases to derive data regarding work activity.…”

Section: Introductionmentioning

confidence: 99%

Headache in Workers: A Matched Case–Control Study

Prinzio

Arnesano

Meraglia

et al. 2022

EJIHPE

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A case–control study including 446 workers reporting headaches (cases; 136 males and 310 females, mean age 46.71 ± 10.84 years) and 446 age- and sex-matched colleagues without headaches (controls; mean age 45.44 ± 10.13) was conducted in the second half of 2020 in a sample drawn from socio health and commercial services companies to investigate the association of headache with lifestyle, metabolic, and work-related factors. Workers suffering from headache reported higher body weight (OR: 1.92, 95% CI: 1.46–2.53, p < 0.001), higher blood cholesterol (OR: 2.01, 95% CI: 1.46–2.77, p < 0.001), triglyceride (OR: 2.01, 95% CI: 1.20–3.35, p < 0.01), blood glucose (OR: 1.91, 95% CI: 1.16–3.24, p < 0.01), and blood pressure levels (OR: 1.76, 95% CI: 1.23–2.52, p < 0.01). In the year preceding the survey, cases had experienced a higher frequency of workplace violence (OR: 2.29, 95% CI: 1.25–4.20, p < 0.01 for physical aggression, OR: 2.22, 95% CI: 1.45–3.41, p < 0.001 for threat, OR: 2.74, 95% CI: 1.72–4.38, p < 0.001 for harassment) and were more frequently distressed (effort/reward ratio > 1) (OR: 1.82, 95% CI: 1.39–2.40, p < 0.001) than the controls. Compared to the controls, cases also had higher scores on anxiety and depression scales, lower scores on happiness, and lower levels of sleep quality (p < 0.001). The association of headaches with metabolic and mental health problems suggests that monitoring headaches in the workplace could help to identify workers at risk of impairment.

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Thrombophilic alterations, migraine, and vascular disease: results from a case-control study

Cited by 7 publications

References 43 publications

Investigation of the relationship between thrombophilic disorders and brain white matter lesions in migraine with aura

Investigation of the relationship between thrombophilic disorders and brain white matter lesions in migraine with aura

Ultrastructural imaging reveals vascular remodeling in migraine patients

Headache in Workers: A Matched Case–Control Study

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