Thrombophilia and Pregnancy: Diagnosis and Management

Tsikouras, Panagiotis; Deftereou, Theodora; Anthoulaki, Xanthoula; Bothou, Anastasia; Chalkidou, Anna; Christoforidou, Anna; Chatzimichael, Elefterios; Gaitatzi, Fotini; Tsirkas, Ioannis; Bourazan, Arsou Chalil; Bampageorgaka, Eirini; Iatrakis, Georgios; Zervoudis, Stefanos; Rath, Werner; Γαλάζιος, Γεώργιος

doi:10.5772/intechopen.85005

Cited by 5 publications

(17 citation statements)

References 64 publications

(252 reference statements)

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“…However, during pregnancy, normal changes occur in the coagulation system of a woman. A reduction in free and total S protein and also a raise in coagulation factors Vc, VIIIc, Xc, and von Willebrand factor antigen are observed [ 6 ]. As we saw in our 30-week gestation case, fetal death appears to have resulted from massive placental thrombosis, while the mechanisms associated with preeclampsia are unknown.…”

Section: Discussionmentioning

confidence: 99%

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Antiphospholipid Syndrome and Preeclampsia in Pregnancy: A Case Report

Skoura¹,

Andronikidi²,

Anestakis³

et al. 2022

Cureus

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Antiphospholipid syndrome (APS) refers to a clinical autoimmune syndrome characterized by arterial or venous thrombosis and pregnancy morbidities, such as fetal loss after the 10th week of gestation, recurrent miscarriages, or intrauterine growth restriction. This study describes a case of preeclampsia in a 37-year-old primiparous woman in the 30th week of pregnancy with a lack of prior thrombotic history. The birth of a dead neonate and the findings of placenta thrombosis raised the suspicion of APS, which was confirmed by the finding of antibodies. A description of the treatment, which is still under investigation, follows. In our case, tissue sections were stained followed by observation. Various placental changes were detected with the presence of placental intravascular thrombi. The most important finding of this case study is the presence of severe preeclampsia in the setting of APS, with no previous medical history. In conclusion, antiphospholipid syndrome can be directly related to preeclampsia during pregnancy, leading to complications that may be preventable if immediate medical intervention is available.

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Section: Discussionmentioning

confidence: 99%

“…The incidence of APS in pregnancy ranges from 0 to 11% (with an average of 2%). However, the APS is detected in up to 37% of cases with SEL [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Antiphospholipid Syndrome and Preeclampsia in Pregnancy: A Case Report

Skoura¹,

Andronikidi²,

Anestakis³

et al. 2022

Cureus

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“…Cesarean Section (CS) rates have been increasing in recent decades worldwide, and this is a global problem because of the negative effect on maternal and neonatal health [ 1 ]. Although CS is a very common surgery, it is associated with an increased risk of hemorrhage, uterine bladder and bowel injury, postoperative sepsis, postoperative ileus [ 2 ] and thromboembolic events [ 3,4 ]. Some studies on neonatal complications have shown that CS is associated with an increased risk for the infant's obesity, diabetes, respiratory morbidity, and atopic dermatitis in childhood [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with the Type of Cesarean Section and the Risk of Postoperative Complications in Greek Women

Antoniou¹,

Orovou²,

Iliadou³

et al. 2022

J Women's Health Dev

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Background Cesarean Section was historically performed to save the lives of mothers and infants. Ηowever, in the past decades, a signi cant increase in Cesarean Section rates have been observed in Greece and worldwide. The purpose of this research was to investigate the contributing factors to the increase in the Cesarean Section rate (emergency and elective) and postoperative complications.Methods A total of births in 6 months (August 2019-February 2020) at the University Hospital of Larisa in Greece was collected. The performed analysis included the available socio-demographic and medical information in the medical records and a socio-demographic and medical questionnaire for women with cesarean deliveries. We also analyzed the importance of the variables in cesarean deliveries compared to vaginal deliveries and postoperative complications.Results Out of the total number of the included 633 births, the vaginal delivery rate was 42% (n = 268), and the cesarean delivery rate was 58% (n = 365); Elective Cesarean Section was performed in 36% (n = 230) of the Cesarean Section cases and Emergency Cesarean Section in 22% (n = 135). Women with a previous Cesarean Section and women with in vitro fertilization showed higher percentages for Elective Cesarean Section (46%) compared to women who underwent an Emergency Cesarean Section for the same reasons (42.2%). Besides, a higher percentage of Emergency Cesarean Sections was observed in women living in urban centers (OR = 4.044, p = 0.002) and those diagnosed with stress disorders (OR = 7.048, p = 0.004). Furthermore, Cesarean Section complications were more common among women having undergone Emergency Cesarean Section (OR = 10.357, p < 0.001).Conclusion The overall high rates of Cesarean Section in Greece demonstrate the lack of national strategies and prevention mechanisms from iatrogenic interventions and lack of promoting good midwifery practices. More speci cally, a decrease in iatrogenic factors leading to the primary Cesarean Section will decrease Cesarean Section rates in Greece.

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“…Congenital thrombophilia is more often associated with some hereditary abnormalities. [1,2] In general population, incidence of congenital thrombophilia depends on the type of disorder. The appearance of antithrombin, C-protein and protein S (natural coagulation inhibitors) deficiency is about 1% in the general population.…”

Section: Introductionmentioning

confidence: 99%

Congenital thrombophilia associated with intrahepatic cholestasis of pregnancy. A case report

Iliadi-Tulbure¹,

Cemortan²,

Bubulici³

et al. 2022

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Intrahepatic cholestasis of pregnancy is pregnancy-specific liver disorder, characterized by pruritus as the main clinical symptom, and fasting liver function tests. The term thrombophilia is used to describe a group of conditions characterized by blood coagulation disorder with increased risk of blood clot formation, which may be congenital or acquired. In general, population the incidence of thrombophilia and intrahepatic cholestasis of pregnancy varies widely, depending on the type of disorder (in case of congenital thrombophilia) and geographical distribution (in case of intrahepatic cholestasis of pregnancy). A high incidence of pregnancy complications makes both congenital thrombophilia and intrahepatic cholestasis of pregnancy very important in clinical practice. At the same time, association between these two disorders is extremely complicated in management, due to perinatal risks. The key-point for the management is cooperation among obstetricians, hematologists, and hepatologists, being crucial for better outcomes.

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Thrombophilia and Pregnancy: Diagnosis and Management

Cited by 5 publications

References 64 publications

Antiphospholipid Syndrome and Preeclampsia in Pregnancy: A Case Report

Antiphospholipid Syndrome and Preeclampsia in Pregnancy: A Case Report

Factors Associated with the Type of Cesarean Section and the Risk of Postoperative Complications in Greek Women

Congenital thrombophilia associated with intrahepatic cholestasis of pregnancy. A case report

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