Intrahepatic cholestasis of pregnancy is a disorder characterized by pruritus and elevated liver function tests and bile acids. Poor vitamin absorption and, as a result, hypovitaminosis K can occur as a result of the pathology. Given the known effects of vitamin K, the authors considered that hypovitaminosis K could increase the risk of coagulopathic hemorrhage in pregnant women. The study revealed that 59.2% of women with intrahepatic cholestasis of pregnancy were diagnosed with hypovitaminosis K; however, 98.6% of women had normal coagulogram indices. Thus, coagulogram markers are more likely to indicate vitamin K activity than its actual level.
Intrahepatic cholestasis of pregnancy is pregnancy-specific liver disorder, characterized by pruritus as the main clinical symptom, and fasting liver function tests. The term thrombophilia is used to describe a group of conditions characterized by blood coagulation disorder with increased risk of blood clot formation, which may be congenital or acquired. In general, population the incidence of thrombophilia and intrahepatic cholestasis of pregnancy varies widely, depending on the type of disorder (in case of congenital thrombophilia) and geographical distribution (in case of intrahepatic cholestasis of pregnancy). A high incidence of pregnancy complications makes both congenital thrombophilia and intrahepatic cholestasis of pregnancy very important in clinical practice. At the same time, association between these two disorders is extremely complicated in management, due to perinatal risks. The key-point for the management is cooperation among obstetricians, hematologists, and hepatologists, being crucial for better outcomes.
Intrahepatic cholestasis of pregnancy (ICP) is a disorder characterized by pruritus and elevated liver function tests. Associated with a high incidence of adverse perinatal outcomes, ICP requires thorough attention in clinical practice. In addition, there is a high rate of stillbirth in cases of ICP. Women with ICP should be informed of the inability to predict stillbirth. Multi-disciplinary cooperation is critical for managing the condition and ensuring better pregnancy outcomes.
Intrahepatic cholestasis of pregnancy is a disorder, characterized by pruritus and elevated liver function tests. Associated with a high incidence of adverse perinatal outcomes, intrahepatic cholestasis of pregnancy (ICP) requires thorough attention in clinical practice. In addition, there is a high rate of stillbirth in cases of ICP. Women with ICP should be informed of the inability to predict stillbirth. Multi-disciplinary cooperation is critical for managing the condition and ensuring better pregnancy outcomes.
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