Thrombolysis and clinical outcome in patients with stroke after implementation of the Tyrol Stroke Pathway: a retrospective observational study

Willeit, Johann; Geley, Theresa; Schöch, Johannes; Rinner, Heinrich; Tür, Andreas; Kreuzer, H. J.; Thiemann, Norbert; Knoflach, Michael; Toell, Thomas; Pechlaner, Raimund; Willeit, Karin; Klingler, Natalie; Praxmarer, Silvia; Baubin, Michael; Beck, Gertrud; Berek, Klaus; Dengg, Christian; Engelhardt, K.; Erlacher, Thomas; Fluckinger, Thomas; Grander, Wilhelm; Grossmann, Josef; Kathrein, Hermann; Kaiser, Norbert; Matosevic, Benjamin; Matzak, Heinrich; Mayr, Markus; Perfler, Robert; Poewe, Werner; Rauter, Alexandra; Schoenherr, Gudrun; Schoenherr, Hans-Robert; Schinnerl, Adolf; Spiss, Heinrich; Thurner, Theresa; Vergeiner, Gernot; Werner, Philipp; Wöll, Ewald; Willeit, Peter; Kiechl, Stefan

doi:10.1016/s1474-4422(14)70286-8

Cited by 56 publications

(63 citation statements)

References 36 publications

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“…(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) In the studies conducted in Europe and Canada, a three-month mRS score of 0-1 was observed in 31%-53% of the patients. (27)(28)(29)(30) SICH occurred in 5.6% of the patients, which was also similar to the previous literature. In studies in the Far East, SICH rates ranged from 3.1% to 7.0%.…”

Section: Discussionsupporting

confidence: 91%

Predictors of functional outcome in patients with stroke thrombolysis in a tertiary hospital in Malaysia

Mls¹,

Kj²,

Kaa³

et al. 2019

smedj

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We recruited patients who were admitted to UMMC, Kuala Lumpur, Malaysia, for AIS between February 2012 and August 2016. The data of consecutive patients from the stroke thrombolysis registry was recorded. The inclusion and exclusion criteria for stroke thrombolysis were based on the National Institute of Neurological Disorders and Stroke trial in the United States. (10) The baseline demographic and clinical data of patients, including age, gender, ethnicity, vascular risk factors, stroke subtypes, blood pressure on admission, National Institutes of Health Stroke Scale (NIHSS)

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Section: Discussionsupporting

confidence: 91%

Predictors of functional outcome in patients with stroke thrombolysis in a tertiary hospital in Malaysia

Mls¹,

Kj²,

Kaa³

et al. 2019

smedj

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“…The effect is clearly seen in Silesia Province, with a tenfold increase of alteplase administration in ischaemic stroke, from less than 1% in 2009 to almost 9% in 2015. This increasing trend is clearly seen in most of the developed countries or regions, however with usually higher thrombolysis rates, as for example in the Netherlands (6.4% in 2005 and 14.6% in 2012 [36], Germany (13.6% in 2012 [37]) or Tyrol, Austria (16.8% in 2013 [38]). In the United States, the percentage of thrombolysis reached almost 30% in some hospitals; however, national general estimates ranged only between 3 and 5% in the last decade [39, 40].…”

Section: Discussionmentioning

confidence: 99%

Early and One-Year Outcomes of Acute Stroke in the Industrial Region of Poland During the Decade 2006–2015: The Silesian Stroke Registry

et al. 2018

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Background: Poland, classified as a high-income country, is still considered to have a high cardiovascular risk population. During the last decade, the standards of care in acute stroke (AS) had markedly improved; thus, we aimed to assess whether and how it translated into early and late outcomes. Methods: Silesian Stroke Registry was created from the administrative database of the public, obligatory, health insurer in Poland. The AS cases were selected based on primary diagnosis coded in ICD-10 as I60-I64 for years 2006–2015 (n = 120,844). Index hospitalization together with data on re-hospitalizations, procedures, ambulatory visits, rehabilitation and all-cause deaths in a 1-year follow-up were analyzed. Results: The rates of admissions per 100,000 adult population varied between 41–47 for haemorrhagic and 257–275 for ischaemic stroke with substantial decrease in almost all age groups except for the oldest patients. In ischaemic stroke, thrombolytic therapy raised from 0 to 8.8% in 2015, along with significant trends of decreasing 30-day (from 20 to 16%) and 12-month (from 35 to 31%) case fatality. In haemorrhagic stroke, case fatality had not changed. After ischaemic stroke, 12-month readmissions due to AS declined from 11–12% in 2006–2009 to 9% in 2010–2014. The percentage of patients benefiting from rehabilitation increased from 24 to 32%. Conclusions: In a large population of industrial province, we showed recent, positive trends in AS admissions, treatment and 1-year outcomes. Development of stroke unit networks and increase in thrombolytic treatment were at least in part responsible for survival improvement and reduction of recurrence of AS. However, case-fatality and stroke recurrence remain high compared to those of other developed countries.

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“…In Austria, a tight stroke unit (SU) network enables ready access to dedicated stroke treatment by ground or helicopter transport all over the mountainous country, which leads to intravenous thrombolysis rates of 17% of patients admitted to these units . Furthermore, a nationwide electronic SU registry was implemented in 2003, which since then has collected a large number of demographic and clinical data including outcome variables to allow for individual benchmarking and quality control.…”

Section: Introductionmentioning

confidence: 99%

Endovascular stroke therapy in Austria: a nationwide 1‐year experience

Serles

Gattringer

Mutzenbach

et al. 2016

Euro J of Neurology

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Thrombolysis and clinical outcome in patients with stroke after implementation of the Tyrol Stroke Pathway: a retrospective observational study

Cited by 56 publications

References 36 publications

Predictors of functional outcome in patients with stroke thrombolysis in a tertiary hospital in Malaysia

Predictors of functional outcome in patients with stroke thrombolysis in a tertiary hospital in Malaysia

Early and One-Year Outcomes of Acute Stroke in the Industrial Region of Poland During the Decade 2006–2015: The Silesian Stroke Registry

Endovascular stroke therapy in Austria: a nationwide 1‐year experience

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