2020
DOI: 10.1007/s10140-020-01868-0
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Thromboembolic complications of COVID-19

Abstract: The symptomology of patients afflicted with novel 2019 coronavirus disease (SARS-CoV-2 or COVID-19) has varied greatly, ranging from the asymptomatic state to debilitating hypoxemic respiratory failure caused by severe atypical viral pneumonia. Patients may also develop a hyper-inflammatory state that can lead to multi-organ failure. It has become increasingly apparent that, as part of the hyper-inflammatory state, COVID-19 infection increases susceptibility to systemic thromboembolic complications that can co… Show more

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Cited by 24 publications
(18 citation statements)
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“…Additionally, features of thrombotic microangiopathy have been demonstrated in 3.3% of 240 patients [ 52 ]. Supporting evidence for thrombotic complications includes rare cases of renal artery or renal vein thrombosis leading to renal infarction [ 61 ].…”
Section: Pathophysiological Mechanisms Of Kidney Involvement In the C...mentioning
confidence: 99%
“…Additionally, features of thrombotic microangiopathy have been demonstrated in 3.3% of 240 patients [ 52 ]. Supporting evidence for thrombotic complications includes rare cases of renal artery or renal vein thrombosis leading to renal infarction [ 61 ].…”
Section: Pathophysiological Mechanisms Of Kidney Involvement In the C...mentioning
confidence: 99%
“…Pulmonary embolisms, strokes, right ventricular thromboses, aortic thromboses, and kidney-related macrovascular events have all been documented in patients with COVID-19. 88 Renal artery thrombosis and renal vein thrombosis have both been documented, including cases with associated renal infarction; however, these are likely rare events. [88][89][90][91][92]…”
Section: Micro or Macrovascular Injury/endothelial Activation Contributing To Ckd Riskmentioning
confidence: 99%
“…88 Renal artery thrombosis and renal vein thrombosis have both been documented, including cases with associated renal infarction; however, these are likely rare events. [88][89][90][91][92]…”
Section: Micro or Macrovascular Injury/endothelial Activation Contributing To Ckd Riskmentioning
confidence: 99%
“…Both arterial and venous thromboembolism is common in patients with severe COVID-19, and thrombosis has been observed in the lungs, heart, kidneys, and brain [4] , [5] . Thrombosis in the vasculature arises from endothelial injury leading to excessive inflammation, platelet activation, and stasis [6] . These manifestations can be classified as an affliction of the endothelium, which serves as one unifying hypothesis in understanding COVID-19 [7] , [8] .…”
Section: Introductionmentioning
confidence: 99%