Thromboelastometric Profile and Acute Coagulopathy of the Polytraumatized Patient: Clinical and Prognostic Implications

Bonet, Antònia; Madrazo, Zoilo; Koo, Maylin; Otero, Ignacio; Mallol, Montserrat; Macia, Irene; Ramirez, Luciano; Sabaté, Antoni

doi:10.1016/j.cireng.2017.09.012

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2022

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Cited by 2 publications

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“…Nevertheless, 25% of patients present acute traumatic coagulopathy (ACT) on arrival at the hospital, 75 and the presence of fibrinolysis is also an aggravating factor for mortality. 75 …”

Section: Discussionmentioning

confidence: 99%

Clinical use of tranexamic acid: evidences and controversies

Contreras

Guilabert

Koo

et al. 2022

Brazilian Journal of Anesthesiology (English Edition)

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“…Nevertheless, 25% of patients present acute traumatic coagulopathy (ACT) on arrival at the hospital, 75 and the presence of fibrinolysis is also an aggravating factor for mortality. 75 …”

Section: Discussionmentioning

confidence: 99%

Clinical use of tranexamic acid: evidences and controversies

Contreras

Guilabert

Koo

et al. 2022

Brazilian Journal of Anesthesiology (English Edition)

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Is ROTEM Diagnostic in Trauma Care Associated with Lower Mortality Rates in Bleeding Patients?—A Retrospective Analysis of 7461 Patients Derived from the TraumaRegister DGU®

Riehl

Lefering

Maegele

et al. 2022

JCM

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Introduction: Death from uncontrolled trauma haemorrhage and subsequent trauma-induced coagulopathy (TIC) is potentially preventable. Point-of-care devices such as rotational thromboelastometry (ROTEM®) are advocated to detect haemostatic derangements more rapidly than conventional laboratory diagnostics. Regarding reductions in RBC transfusion, the use of ROTEM has been described as being efficient and associated with positive outcomes in several studies. Objective: The effect of ROTEM use was assessed on three different outcome variables: (i) administration of haemostatics, (ii) rate of RBC transfusions and (iii) mortality in severely injured patients. Methods and Material: A retrospective analysis of a large data set of severely injured patients collected into the TraumaRegister DGU® between 2009 and 2016 was conducted. The data of 7461 patients corresponded to the inclusion criteria and were subdivided into ROTEM-using and ROTEM-non-using groups. Both groups were analysed regarding (i) administration of haemostatics, (ii) rate of RBC transfusions and (iii) mortality. Results: A lower mortality rate in ROTEM-using groups was observed (p = 0.043). Furthermore, more patients received haemostatic medication when ROTEM was used. In ROTEM-using groups, there was a statistically relevant higher application of massive transfusion. Conclusions: In this retrospective study, the use of ROTEM was associated with reduced mortality and an increased application of haemostatics and RBC transfusions. Prospective evidence is needed for further evidence-based recommendations.

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Thromboelastometric Profile and Acute Coagulopathy of the Polytraumatized Patient: Clinical and Prognostic Implications

Cited by 2 publications

References 19 publications

Clinical use of tranexamic acid: evidences and controversies

Clinical use of tranexamic acid: evidences and controversies

Is ROTEM Diagnostic in Trauma Care Associated with Lower Mortality Rates in Bleeding Patients?—A Retrospective Analysis of 7461 Patients Derived from the TraumaRegister DGU®

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