Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma-induced coagulopathy in adult trauma patients with bleeding

Hunt, Harriet; Stanworth, Simon; Curry, Nicola; Woolley, Tom; Cooper, Chris; Ukoumunne, Obioha C; Zhelev, Zhivko; Hyde, Chris

doi:10.1002/14651858.cd010438.pub2

Cited by 179 publications

(150 citation statements)

References 65 publications

Supporting

Mentioning

144

Contrasting

Unclassified

Order By: Relevance

“…The last few years have seen a growing interest in the use of thromboelastography, a global hemostasis test which measures the dynamics of the entire clotting and fibrinolysis process, for the assessment of bleeding and thrombotic risk in various clinical settings [9][10][11][12][13]. Recently, it has been shown that rotation thromboelastometry (ROTEM) may be helpful in indicating the prothrombotic state, which is present at diagnosis in patients with multiple myeloma and essential thrombocythemia [14,15].…”

mentioning

confidence: 99%

Assessment of Selected ROTEM Parameters, Kinetics of Fibrinogen Polymerization and Plasmin Amidolytic Activity in Patients with Congenital Fibrinogen Defects

et al. 2016

View full text Add to dashboard Cite

mentioning

confidence: 99%

Assessment of Selected ROTEM Parameters, Kinetics of Fibrinogen Polymerization and Plasmin Amidolytic Activity in Patients with Congenital Fibrinogen Defects

et al. 2016

View full text Add to dashboard Cite

“…21 Despite the conflicting data, the Trauma Quality Improvement Project of the American College of Surgeons suggests that all Level I and II trauma centers have TEG available. 51 Similarly, the European Trauma Guidelines suggest that ROTEM be performed to assist in the characterization of the coagulopathy and in guiding hemostatic therapy.…”

Section: Utility Of Vhas In Other Surgical Specialtiesmentioning

confidence: 99%

Neurosurgical applications of viscoelastic hemostatic assays

Kvint¹,

Schuster²,

Kumar

2017

Neurosurgical Focus

View full text Add to dashboard Cite

Patients taking antithrombotic agents are very common in neurosurgical practice. The perioperative management of these patients can be extremely challenging especially as newer agents, with poorly defined laboratory monitoring and reversal strategies, become more prevalent. This is especially true with emergent cases in which rapid reversal of anticoagulation is required and the patient’s exact medical history is not available. With an aging patient population and the associated increase in diseases such as atrial fibrillation, it is expected that the use of these agents will continue to rise in coming years. Furthermore, thromboembolic complications such as deep venous thrombosis, pulmonary embolism, and myocardial infarction are common complications of major surgery. These trends, in conjunction with a growing understanding of the hemostatic process and its contribution to the pathophysiology of disease, stress the importance of the complete evaluation of a patient’s hemostatic profile in guiding management decisions. Viscoelastic hemostatic assays (VHAs), such as thromboelastography and rotational thromboelastometry, are global assessments of coagulation that account for the cellular and plasma components of coagulation. This FDA-approved technology has been available for decades and has been widely used in cardiac surgery and liver transplantation. Although VHAs were cumbersome in the past, advances in software and design have made them more accurate, reliable, and accessible to the neurosurgeon. VHAs have demonstrated utility in guiding intraoperative blood product transfusion, identifying coagulopathy in trauma, and managing postoperative thromboprophylaxis. The first half of this review aims to evaluate and assess VHAs, while the latter half seeks to appraise the evidence supporting their use in neurosurgical populations.

show abstract

“…TEG results from analysis of whole blood may be available in less than 5 minutes and provide essential, timely data for resuscitation. 22 Although use of TEG has increased, results of a recent systematic review 23 revealed little diagnostic accuracy associated with the use of TEG compared with traditional coagulation …”

Section: Pathophysiology Of Trauma and Associated Hemorrhagementioning

confidence: 99%

Consequences of Transfusing Blood Components in Patients With Trauma: A Conceptual Model

Jones

Frazier

2017

Critical Care Nurse

View full text Add to dashboard Cite

Transfusion of blood components is often required in resuscitation of patients with major trauma. Packed red blood cells and platelets break down and undergo chemical changes during storage (known as the storage lesion) that lead to an inflammatory response once the blood components are transfused to patients. Although some evidence supports a detrimental association between transfusion and a patient’s outcome, the mechanisms connecting transfusion of stored components to outcomes remain unclear. The purpose of this review is to provide critical care nurses with a conceptual model to facilitate understanding of the relationship between the storage lesion and patients’ outcomes after trauma; outcomes related to trauma, hemorrhage, and blood component transfusion are grouped according to those occurring in the short-term (≤30 days) and the long-term (>30 days). Complete understanding of these clinical implications is critical for practitioners in evaluating and treating patients given transfusions after traumatic injury.

show abstract

Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma-induced coagulopathy in adult trauma patients with bleeding

Cited by 179 publications

References 65 publications

Assessment of Selected ROTEM Parameters, Kinetics of Fibrinogen Polymerization and Plasmin Amidolytic Activity in Patients with Congenital Fibrinogen Defects

Assessment of Selected ROTEM Parameters, Kinetics of Fibrinogen Polymerization and Plasmin Amidolytic Activity in Patients with Congenital Fibrinogen Defects

Neurosurgical applications of viscoelastic hemostatic assays

Consequences of Transfusing Blood Components in Patients With Trauma: A Conceptual Model

Contact Info

Product

Resources

About