This guideline provides timely, evidence-based reversal strategies to assist practitioners in the care of patients with antithrombotic-associated intracranial hemorrhage.

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Anemia is common in acute ICH and its presence at admission is an independent predictor of larger volume of ICH. Given the central role of ICH volume in outcome, clarification of the mechanisms underlying this relationship may offer novel therapeutic targets for reducing ICH morbidity and mortality.

Considerable research has focused on overly positive self-perceptions (self-enhancement), and yet little is known about the underlying neural mechanisms. The present study sought to assess the neural correlates of self-enhancement by applying Transcranial Magnetic Stimulation (TMS) to three brain regions. Twelve participants rated their best friend, as well as the self on a set of desirable or undesirable traits while TMS pulses were delivered in a virtual lesion manner. During the baseline condition (Sham TMS), participants produced more desirable and fewer undesirable ratings for themselves as compared to their best friend, showing self-enhancement. Compared to Sham TMS, TMS delivered to the Medial Prefrontal Cortex (MPFC) reduced self-enhancement whereas TMS delivered to the Supplementary Motor Area (SMA) and the precuneus did not. Together, these findings suggest that the MPFC may influence self-enhancement.

To report 3 patients who developed anti-N-methyl-D-aspartate receptor encephalitis during pregnancy. Design: Case reports. Setting: University hospitals. Patients: Three young women developed at 14, 8, and 17 weeks of gestation acute change of behavior, prominent psychiatric symptoms, progressive decrease of consciousness, seizures, dyskinesias, and autonomic dysfunction. Main Outcome Measures: Clinical, radiological, and immunological findings. Results: The 3 patients had cerebrospinal fluid pleocytosis, normal magnetic resonance imaging, and electroencephalogram showing slow activity. All had higher antibody titers in cerebrospinal fluid than in serum and 2 had ovarian teratomas that were removed. The pregnancy was terminated in 1 patient with recurrent bilateral teratomas. All patients had substantial neurological recoveries, and the 2 newborns were normal. Results of extensive antibody testing in 1 of the babies were negative. Conclusion: The current study shows that anti-NMDAR encephalitis during pregnancy can have a good outcome for the mother and newborn.

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Careful patient monitoring using a variety of techniques including clinical and laboratory evaluation, bedside physiological monitoring with continuous or non-continuous techniques and imaging is fundamental to the care of patients who require neurocritical care. How best to perform and use bedside monitoring is still being elucidated. To create a basic platform for care and a foundation for further research the Neurocritical Care Society in collaboration with the European Society of Intensive Care Medicine, the Society for Critical Care Medicine and the Latin America Brain Injury Consortium organized an international, multidisciplinary consensus conference to develop recommendations about physiologic bedside monitoring. This supplement contains a Consensus Summary Statement with recommendations and individual topic reviews as a background to the recommendations. In this article, we highlight the recommendations and provide additional conclusions as an aid to the reader and to facilitate bedside care.

The mobilization of patients with EVDs is safe and feasible; it may be associated with earlier mobilization, reduced ICU LOS, and better discharge disposition. No major complications were attributable to early mobilization.