Thrombocytosis Portends Adverse Prognosis in Colorectal Cancer: A Meta-Analysis of 5,619 Patients in 16 Individual Studies

Gu, Dongmin; Szállaśi, A

doi:10.21873/anticanres.11878

Cited by 18 publications

(15 citation statements)

References 17 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The negative impact of elevated platelets on DMFS is in line with preclinical evidence that suggests an important role for platelets in metastasis ( 26 ). Similar data have been reported before in other tumor types, such as colorectal cancer ( 27 , 28 ). Also, prophylactic aspirin that inhibits platelet activation has been shown to decrease metastatic incidence and cancer mortality ( 44 ).…”

Section: Discussionsupporting

confidence: 91%

“…Clinical and preclinical evidence suggests that platelets can help tumor cells resist apoptosis, induce angiogenesis, facilitate chemoresistance, and help immune evasion during generation of metastasis ( 25 , 26 ). Elevated pretreatment platelets are associated with worse outcome in colorectal cancer patients ( 27 ) and a higher propensity for metastasis ( 28 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer

et al. 2017

View full text Add to dashboard Cite

Peripheral blood leukocytosis has been implicated in promoting tumor progression leading to worse survival, but the mechanisms behind this phenomenon remain unexplored. Here, we examined the prognostic role of pretreatment white blood cell (WBC) count and clinicopathologic parameters in the context of CD8+ tumor-infiltrating lymphocytes (TIL) and myeloperoxidase+ tumor-associated neutrophils (TANs) in patients with anal squamous cell carcinoma (ASCC) treated with definitive chemoradiotherapy (CRT). After a median follow-up of 26 months, leukocytosis correlated with advanced T-stage (p < 0.001) and N-stage (p < 0.001), and predicted for worse distant-metastasis-free survival (p = 0.006), disease-free-survival (DFS, p = 0.029), and overall survival (p = 0.013). Importantly, leukocytosis was associated with a lower intraepithelial CD8+ TIL density (p = 0.014), whereas low CD8+ TIL expression in the intraepithelial compartment was associated with worse DFS (p = 0.028). Additionally, high TAN expression in the peritumoral compartment was associated with a significantly lower density of CD8+ TIL (p = 0.039), albeit, TAN expression lacked prognostic value. In conclusion, leukocytosis constitutes an important prognostic marker in ASCC patients treated with CRT. In conjunction with intratumoral TIL and TAN, these data provide for the first time important insight on the correlation of peripheral blood leukocytosis with the intratumoral immune contexture and could be relevant for future patient stratification using immunotherapies in ASCC.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In most of the previous studies, both NLR and PLR were found to be valuable in several solid tumors (18,19,20,21). Costantini et al (22) suggested that production of bone marrow-stimulating cytokines as a result of inflammatory response to malignancy may play an important role in the regulation of platelet counts in neoplasms (23). Platelets can give rise to angiogenesis and extra-vasation of tumor cells by releasing vascular endothelial growth factor (VEGF) (24).…”

Section: Discussionmentioning

confidence: 99%

The Correlation of Clinicopathological Findings and Neutrophil-to- Lymphocyte and Platelet-to-Lymphocyte Ratios in Papillary Thyroid Carcinoma

Ceylan

Kumanlıoğlu

Oral

et al. 2019

Mirt

View full text Add to dashboard Cite

Objectives: Inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been recently introduced as potential biomarkers for tumor pathogenesis, development and prognosis in solid tumors. Our aim was to assess the correlation of clinicopathological features and NLR and PLR in patients with papillary thyroid carcinoma (PTC). Methods: A total of 201 papillary thyroid carcinoma patients were divided into groups with a cut-off preoperative median NLR and PLR value of 1,92 and 123.9, respectively. The correlation of NLR and PLR and clinicopathological features including age, tumor size, extra-thyroidal extension, thyroid capsule invasion, surgical margin positivity, multifocality, bilaterality of the patients were analyzed. Results: The mean NLR and PLR were 2.11±0.94, 129.69±42.81, respectively. Larger tumor size and higher positivity of extra-thyroidal spread were correlated with higher NLR values. No significant relationship was found between NLR and age, presence of thyroid capsule invasion, surgical margin positivity, multifocality, bilaterality, and lymph node metastasis. Also no significant association was observed between the clinicopathological features and PLR. Conclusion: High NLR was found to correlate with tumor size and extra-thyroidal extension. NLR may be used as a marker to determine the clinical behavior of disease in patients with papillary thyroid carcinoma (PTC).

show abstract

“…Preoperative anemia, reflecting systemic inflammation in a subset of patients, has also been associated with adverse outcome[150]. Platelet count and platelet-to-lymphocyte ratio can also provide potentially clinically relevant prognostic information[151-153], with high platelet counts associated with poor survival. In future, more sophisticated analyses of platelet composition and function, such as platelet RNA sequencing, may complement these parameters to provide more nuanced information of the status of platelet activation and education during systemic inflammation[21].…”

Section: Prognostic Significance Of Systemic Inflammation and Associamentioning

confidence: 99%

Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance

Tuomisto

Mäkinen

Väyrynen

2019

WJG

185

181

View full text Add to dashboard Cite

Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-40% of colorectal cancer patients. The hallmarks of systemic inflammation include an increased production of proinflammatory cytokines and acute phase proteins that enter the circulation. While the low-level systemic inflammation is often clinically silent, its consequences are many and may ultimately lead to chronic cancer-associated wasting, cachexia. In this review, we discuss the pathogenesis of cancer-related systemic inflammation, explore the role of systemic inflammation in promoting cancer growth, escaping antitumor defense, and shifting metabolic pathways, and how these changes are related to less favorable outcome.

show abstract

Thrombocytosis Portends Adverse Prognosis in Colorectal Cancer: A Meta-Analysis of 5,619 Patients in 16 Individual Studies

Abstract: Thrombocytosis portends adverse prognosis in CRC, and may serve as a clinically useful marker to facilitate risk stratification and guide postoperative management.

Cited by 18 publications

References 17 publications

Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer

Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer

The Correlation of Clinicopathological Findings and Neutrophil-to- Lymphocyte and Platelet-to-Lymphocyte Ratios in Papillary Thyroid Carcinoma

Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance

Contact Info

Product

Resources

About