The Correlation of Clinicopathological Findings and Neutrophil-to- Lymphocyte and Platelet-to-Lymphocyte Ratios in Papillary Thyroid Carcinoma

Abstract

Objectives: Inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been recently introduced as potential biomarkers for tumor pathogenesis, development and prognosis in solid tumors. Our aim was to assess the correlation of clinicopathological features and NLR and PLR in patients with papillary thyroid carcinoma (PTC). Methods: A total of 201 papillary thyroid carcinoma patients were divided into groups with a cut-off preoperative median NLR and PLR value of 1,92 and 123.9, respectively. The correlation of NLR and PLR and clinicopathological features including age, tumor size, extra-thyroidal extension, thyroid capsule invasion, surgical margin positivity, multifocality, bilaterality of the patients were analyzed. Results: The mean NLR and PLR were 2.11±0.94, 129.69±42.81, respectively. Larger tumor size and higher positivity of extra-thyroidal spread were correlated with higher NLR values. No significant relationship was found between NLR and age, presence of thyroid capsule invasion, surgical margin positivity, multifocality, bilaterality, and lymph node metastasis. Also no significant association was observed between the clinicopathological features and PLR. Conclusion: High NLR was found to correlate with tumor size and extra-thyroidal extension. NLR may be used as a marker to determine the clinical behavior of disease in patients with papillary thyroid carcinoma (PTC).

<p>Association of the Preoperative Inflammation-Based Scores with TNM Stage and Recurrence in Patients with Papillary Thyroid Carcinoma: A Retrospective, Multicenter Analysis</p>

“…Previous studies have evaluated the relationship between preoperative inflammation-based scores and tumor size in patients with PTC, but the results have been contradictory. Y. Ceylan's study 30 reported that a high preoperative NLR was associated with a large tumor size; similar results were also found in other studies. 17,19,22 However, in SM Kim's study, 18 a large tumor size was correlated with a high PLR instead of a high NLR, although that study included only female patients.…”

Clinical significance of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio and prognostic nutritional index in low-risk differentiated thyroid carcinoma

“…According to the most recent studies, there are few correlations between PLR and prognosis of patients with DTC. Ceylan et al found no correlation between clinicopathologic features of PTC and PLR 23 . Ozmen et al reported that PLR and NLR are more successful indexes for diagnosis and recurrence of DTC than C-reactive protein (they included FTC, PTC and microcarcinoma).…”

“…Chen et al suggested that a low NLR (≤ 1.6) is associated with a high risk of PTC recurrence, but with a follow-up of 12.2 ± 3.8 months it is not possible to have an estimate of DFS and OS at 5 or 10 years 22 . Ceylan et al suggested an NLR cut-off value of 1.92 and a correlation between a high NLR, large tumour size and positivity of extra-thyroidal spread 23 . Seretis et al reported that an elevated preoperative mean NLR is present in patients with microcarcinoma and in DTC, and found that elevated mean NLR does not show any significant difference between patients with multifocal or unifocal microcarcinoma.…”

Relationship Between Serum Inflammatory Factor Levels and Differentiated Thyroid Carcinoma

“…As suggested in some recent studies, NLR and PLR, which are easily obtained from blood tests, significantly elevate in patients with PTC or FTC, and such results are consistent with our. 19 Ari A et al reported that NLR and PLR were higher in patients with papillary thyroid cancer than in healthy individuals, with statistically significant difference in PLR. 20 Similarly, in the current study, PLR was significantly higher in patients with PTC than in healthy individuals, and NLR was also significantly higher.…”