Thrombocytopenia in<i>Plasmodium falciparum</i>,<i>Plasmodium vivax</i>and mixed infection malaria: A study from Bikaner (Northwestern India)

Kochar, Dhanpat Kumar; Das, Ashis; Kochar, Anju; Middha, Sheetal; Acharya, Jyoti; Tanwar, Gajanand Singh; Gupta, Anjana; Pakalapati, Deepak; Garg, Shilpi; Saxena, Vishal; Subudhi, Amit Kumar; Boopathi, P.A.; Sirohi, Parmendra; Kochar, Sanjay Kumar

doi:10.3109/09537104.2010.505308

Cited by 83 publications

(85 citation statements)

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“…14 Another study done by Kochar DK et al showed only 31% patients had thrombocytopenia, this difference is because they had included both inpatients as well as outpatients suffering from malaria. 15 One other study on outpatients only by Goyal et al, showed 77% patients had thrombocytopenia. 16 Frank bleeding was present in 14 of total studied population and had both PV and PF infection, and all were pancypenic.…”

Section: 11mentioning

confidence: 99%

“…Study done by Kochar DK et al showed 18.18% patients had platelet count less than 20000/microlitre, and only 0.6% patients had bleeding manifestations. 15 Study done by Chetiwal R et al showed 88% patients had thrombocytopenia, and mean platelet count was 79442/ microlitre, 6.9% patient had platelet count less than 20000/microlitre, and only 2.3% patients had bleeding manifestations. 13 In this study life, threatening complications were present in 46 patients.…”

Section: 11mentioning

confidence: 99%

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To study hematological profile in malaria patients

Yadav

Kumar

2017

Int J Adv Med

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Background: Malaria has been a problem in India for centuries and it is responsible for many deaths in rural areas. This study was done to observe hematological profile in malaria patients and to study the incidence of complications in different species of malaria patients and to find any relation with hematological changes.Methods: The study was conducted at MLN Medical College, Allahabad in the Department of Medicine between January 2016 to December 2016. One hundred consecutive patients aged 18 years or more with malaria fever were interviewed and examined.Results: Out of 100 patients 26 patients had Plasmodium vivax malaria and 59 patients had Plasmodium falciparum infection while 15 patients had mixed PV and PF infection. In present study thrombocytopenia was most common hematological abnormality. Thrombocytopenia was present in 87 patients, out of them 18 had very severe thrombocytopenia while 69 had mild to moderate thrombocytopenia. Frank bleeding was present in 14 of total studied population and had both PV and PF infection. Petechial rashes were present in 10 patients. Anemia was present in 80 patients.Conclusions: Thrombocytopenia is very frequent finding in patients suffering from malaria, and even in presence of thrombocytopenia bleeding manifestations are uncommon. So, platelet transfusion should not be performed routinely in all thrombocytopenia patients, rather it should be indicated only if bleeding manifestations are present. Anemia, pancytopenia and leucopenia are other frequent laboratory findings of malaria infection.

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Section: 11mentioning

confidence: 99%

Section: 11mentioning

confidence: 99%

To study hematological profile in malaria patients

Yadav

Kumar

2017

Int J Adv Med

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“…Studies have postulated that malaria should be suspected in travelers who present with fever and thrombocytopenia 34 . In malaria patients, thrombocytopenia is generally mild or moderate 13,17 , and bleeding is rare 35,36 . One study found that severe thrombocytopenia in malaria was an independent predictor of death (odds ratio (OR)=13.3, 95%CI=3.2-55.1) 37 , but this finding has been contested 9 .…”

Section: Introductionmentioning

confidence: 99%

“…Thrombocytopenia has been associated with Plasmodium knowlesi 8 , Plasmodium falciparum 9 , Plasmodium vivax, Plasmodium ovale 10 and Plasmodium malariae infections 11 . The evidence is mixed regarding the existence of a correlation between platelet count (PC) and parasitemia [8][9][10][12][13][14] . In a systematic review, Lacerda et al found no differences in the frequency of thrombocytopenia across species of Plasmodium; the frequency of thrombocytopenia ranged from 24-94% in all studies 6 .…”

Section: Introductionmentioning

confidence: 99%

Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia

Martinez-Salazar

Tobón-Castaño

2014

Rev. Soc. Bras. Med. Trop.

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Introduction: Thrombocytopenia is a common complication in malaria patients. The relationship between abnormal platelet profi le and clinical status in malaria patients is unclear. In low and unstable endemic regions where vivax malaria predominates, the hematologic profi les of malaria patients and their clinical utility are poorly understood. The aim of this study was to characterize the thrombograms of malaria patients from Colombia, where Plasmodium vivax infection is common, and to explore the relationship between thrombograms and clinical status. Methods: Eight hundred sixty-two malaria patients were enrolled, including 533 (61.8%) patients infected with Plasmodium falciparum, 311 (36.1%) patients infected with Plasmodium vivax and 18 (2.1%) patients with mixed infections. Results: The most frequently observed changes were low platelet count (PC) and high platelet distribution width (PDW), which were observed in 65% of patients; thrombocytopenia with <50,000 platelets/µL was identifi ed in 11% of patients. Patients with complications had lower PC and plateletcrit (PT) and higher PDW values. A higher risk of thrombocytopenia was identifi ed in patients with severe anemia, neurologic complications, pulmonary complications, liver dysfunction, renal impairment and severe hypoglycemia. The presence of thrombocytopenia (<150,000 platelets/µL) was associated with a higher probability of liver dysfunction. Conclusions: Young age, longer duration of illness and higher parasitemia are associated with severe thrombocytopenia. Our study showed that thrombocytopenia is related to malaria complications, especially liver dysfunction. High PDW in patients with severe malaria may explain the mechanisms of thrombocytopenia that is common in this group of patients.

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“…In addition, severe thrombocytopenia (platelets <2 × 10 4 /mm 3 ) may be a common manifestation of vivax monoinfection 5 . Role of platelet phagocytosis has been suggested in vivax malaria 6 .…”

Section: Introductionmentioning

confidence: 99%

Vivax-induced thrombocytopenia may be associated with lymphopenia and mild anaemia. Correlation of RBC parameters with WBC and platelet counts – A report of 13 patients with vivax malaria

Singh¹

2017

JMSCR

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Thrombocytopenia inPlasmodium falciparum,Plasmodium vivaxand mixed infection malaria: A study from Bikaner (Northwestern India)

Cited by 83 publications

References 20 publications

To study hematological profile in malaria patients

To study hematological profile in malaria patients

Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia

Vivax-induced thrombocytopenia may be associated with lymphopenia and mild anaemia. Correlation of RBC parameters with WBC and platelet counts – A report of 13 patients with vivax malaria

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