Threshold dose distributions for 5 major allergenic foods in children

Blom, W. Marty; Vlieg‐Boerstra, Berber; Kruizinga, Astrid G.; Heide, S. van der; Houben, Geert F.; Dubois, Anthony

doi:10.1016/j.jaci.2012.10.034

Cited by 121 publications

(116 citation statements)

References 37 publications

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“…In this study, patients with hazelnut allergy were the most sensitised group since 5% and 10% of the tested population is likely to respond with objective symptoms to 0.3 mg (ED 05 ) and 1.4 mg (ED 10 ) of hazelnut protein, respectively. Moreover, the same target population evidenced any type of symptoms for the estimated threshold level of 0.05 mg of hazelnut protein (Blom et al, 2013).…”

Section: Clinical Threshold Levels For Hazelnutmentioning

confidence: 79%

“…In the same study, those authors were able to predict that 8.7 mg and 15.9 mg Downloaded by [New York University] at 00:30 24 June 2015 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 10 of hazelnut protein were sufficient to induce allergic reactions in 5% and 10% of the hazelnutallergic population, respectively (Eller et al, 2012). Another study estimating the threshold distribution of seven allergenic foods (egg, milk, peanut, hazelnut, walnut, cashew nut and soy) was conducted using DBPCFC in children and adolescents (0-18 years-old) as test-population (Blom et al, 2013). In this study, patients with hazelnut allergy were the most sensitised group since 5% and 10% of the tested population is likely to respond with objective symptoms to 0.3 mg (ED 05 ) and 1.4 mg (ED 10 ) of hazelnut protein, respectively.…”

Section: Clinical Threshold Levels For Hazelnutmentioning

confidence: 99%

“…The distribution of the threshold level for hazelnut reported by those studies is rather different, which suggests that further investigation regarding this topic is still needed. However, these data represent a step forward in the elaboration of precautionary labelling action levels and for the incorporation in the risk assessment for adverse immunological reactions in the allergic population, upon eventual consumption of foods contaminated with allergens (Blom et al, 2013).…”

Section: Clinical Threshold Levels For Hazelnutmentioning

confidence: 99%

See 2 more Smart Citations

Hazelnut Allergens: Molecular Characterization, Detection, and Clinical Relevance

Costa

Mafra

Carrapatoso

et al. 2015

Critical Reviews in Food Science and Nutrition

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In last few years, special attention has been given to food-induced allergies, in which hazelnut allergy is highlighted. Hazelnut is one of the most commonly consumed tree nuts, being largely used by the food industry in a variety of processed foods. It has been regarded as a food with potential health benefits, but also as a source of allergens capable of inducing mild to severe allergic reactions in sensitized individuals. Considering the great number of reports addressing hazelnut allergens, with an estimated increasing trend, this review intends to assemble all the relevant information available so far on the following main issues: prevalence of tree nut allergy, clinical threshold levels, molecular characterization of hazelnut allergens (Cor a 1, Cor a 2, Cor a 8, Cor a 9, Cor a 10, Cor a 11, Cor a 12, Cor a 14, and Cor a TLP) and their clinical relevance, and methodologies for detection of hazelnut allergens in foods. A comprehensive overview of the current data about the molecular characterization of hazelnut allergens is presented, relating to biochemical classification and biological function with clinical importance. Recent advances in hazelnut allergen detection methodologies are summarized and compared, including all the novel protein-based and DNA-based approaches.

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Section: Clinical Threshold Levels For Hazelnutmentioning

confidence: 79%

Section: Clinical Threshold Levels For Hazelnutmentioning

confidence: 99%

Section: Clinical Threshold Levels For Hazelnutmentioning

confidence: 99%

See 1 more Smart Citation

Hazelnut Allergens: Molecular Characterization, Detection, and Clinical Relevance

Costa

Mafra

Carrapatoso

et al. 2015

Critical Reviews in Food Science and Nutrition

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“…A low dose of egg protein (< 4,000 mg/week) was associated with a more successful primary prevention of egg allergy compared to a high dose (> 4,000 mg/week). This low dose is much higher than the threshold of 1.5 mg shown to cause an allergic reaction in children [25]. The difference in effect between a low versus high egg protein dose is likely to have important implications for clinical practice and future research.…”

Section: Discussionmentioning

confidence: 99%

Early Introduction of Egg and the Development of Egg Allergy in Children: A Systematic Review and Meta-Analysis

Al‐Saud

Sigurdardottir

2018

Int Arch Allergy Immunol

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Background: The timing of the introduction of egg to an infant’s diet is of current interest, as new evidence raises questions regarding the benefit of delaying egg introduction. The objective of this study was to systematically review the existing literature regarding the effect of the early introduction of egg on the development of egg allergy. Methods: Literature searches were conducted in MEDLINE, EMBASE, and CENTRAL, and trial protocols were searched in Meta Register and OpenGREY. Only randomized controlled trials (RCTs) comparing early (between 3 and 6 months of age) egg introduction to no early introduction were included. The primary outcome was the development of egg allergy. Results: Of the 416 articles identified and screened, 6 RCTs met the eligibility criteria for data extraction. Allergic outcomes were evaluated in a total of 3,032 participants. A low to moderate level of evidence showed a benefit of the early introduction of egg (relative risk, RR 0.60, 95% CI 0.44–0.82, p = 0.002, mild heterogeneity, I² = 23%). The absolute risk reduction for a population with an incidence of egg allergy of 9.3% was 37 fewer cases (95% CI 17–52) per 1,000 people. Consumption of < 4,000 mg/week of egg protein had a greater preventive effect than a higher dose. Conclusion: This systematic review and meta-analysis showed an association between the early introduction of egg and a lower risk of egg allergy. Furthermore, the nature and dose of egg protein exposure may play a role. These findings should be addressed in the context of primary studies.

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“…A recent study has examined allergen threshold levels for 5 common food allergens among 2-18 year old children, which helped researchers predict the dose of allergen that can elicit allergic reaction among 5% of allergic population (23).…”

Section: Oral Food Challengesmentioning

confidence: 99%

The Diagnosis and Management of Food Allergy in Childhood

Semiç-Jusufagiç

2014

Pediatr Today

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Food allergy has reached epidemic proportions in developed countries over the past few decades for reasons not well understood. With the growing disease burden and the need to improve food allergy diagnosis, better diagnostics tools such as component resolved diagnostics (CRD) have been introduced for clinical use. Still, oral food challenges remain the gold standard tool for establishing food allergy diagnosis. Current food allergy management strategies rely on avoidance of the culprit allergen. Inspired by the success of specific immunotherapy in inhalant allergy, the past decade has been marked by increasing international effort to find curative treatments. The results from several clinical trials, examining success of allergen-specific immunotherapy in food allergy, have recently become available and are discussed within this review article. Conclusion -The results from these clinical trials promise new curative therapies for food allergy sufferers in the near future. Moreover, several ongoing interventional studies looking into early-life introduction of allergenic foods could provide us with specific answers on future primary prevention strategies.

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Threshold dose distributions for 5 major allergenic foods in children

Cited by 121 publications

References 37 publications

Hazelnut Allergens: Molecular Characterization, Detection, and Clinical Relevance

Hazelnut Allergens: Molecular Characterization, Detection, and Clinical Relevance

Early Introduction of Egg and the Development of Egg Allergy in Children: A Systematic Review and Meta-Analysis

The Diagnosis and Management of Food Allergy in Childhood

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