Three-Year Study of Viral Etiology and Features of Febrile Respiratory Tract Infections in Japanese Pediatric Outpatients

Hara, Michimaru; Takao, Shinichi; Shimazu, Yukie; Nishimura, Tatsuo

doi:10.1097/inf.0000000000000227

Cited by 19 publications

(13 citation statements)

References 38 publications

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“…Although a similar trend was observed for MPV and PIV, the small sample sizes for asymptomatic detection of these viruses may have limited our power to detect significant differences. While infection with some of these viruses may be associated with rhinorrhea alone,(51, 52) or rhinorrhea may enhance viral detection from the nasopharynx, the interpretation of this finding should take into account that our definition of ARI only included cough and fever, but not rhinorrhea.…”

Section: Discussionmentioning

confidence: 99%

Respiratory Viral Detections During Symptomatic and Asymptomatic Periods in Young Andean Children

Howard

Johnson

Williams

et al. 2015

Pediatric Infectious Disease Journal

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Background Viruses are commonly detected in children with acute respiratory illnesses (ARI) and in asymptomatic children. Longitudinal studies of viral detections during asymptomatic periods surrounding ARI could facilitate interpretation of viral detections but are currently scant. Methods We used reverse transcription-polymerase chain reaction (RT-PCR) to analyze respiratory samples from young Andean children for viruses during asymptomatic periods within 8-120 days of index ARI (cough or fever). We compared viral detections over time within children and explored RT-PCR cycle thresholds (CT) as surrogates for viral loads. Results At least one respiratory virus was detected in 367 (43%) of 859 samples collected during asymptomatic periods, with more frequent detections in periods with rhinorrhea (49%) than those without (34%, p<0.001). Relative to index ARI with human rhinovirus (HRV), adenovirus (AdV), respiratory syncytial virus (RSV), and parainfluenza virus (PIV) detected, the same virus was also detected during 32%, 22%, 10%, and 3% of asymptomatic periods, respectively. RSV was only detected 8-30 days after index RSV ARI, whereas HRV and AdV were detected throughout asymptomatic periods. Human metapneumovirus (MPV) and influenza were rarely detected during asymptomatic periods (<3%). No significant differences were observed in the CT for HRV or AdV during asymptomatic periods relative to ARI. For RSV, CT were significantly lower during ARI relative to the asymptomatic period (p=0.03). Conclusions These findings indicate that influenza, MPV, PIV, and RSV detections in children with ARI usually indicate a causal relationship. When HRV or AdV is detected during ARI, the causal relationship is less certain.

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Section: Discussionmentioning

confidence: 99%

Respiratory Viral Detections During Symptomatic and Asymptomatic Periods in Young Andean Children

Howard

Johnson

Williams

et al. 2015

Pediatric Infectious Disease Journal

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“…On the other hand, for PIVs, RSV, and hCoV OC43, which were detected only when clinical symptoms were seen, it is thought that, if these viruses grow in the airway, certain host reactions such as respiratory symptoms or fever will be triggered [22][23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Detection of respiratory viruses in gargle specimens of healthy children

Morikawa

Hiroi

Kase

2015

Journal of Clinical Virology

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“…HRV infection may not be highly associated with fever as it was only present at a low rate on HRV-single-positive occasions (11.5 %, 3/26). In fact, in a previous study concerning febrile respiratory tract infections in Japanese paediatric outpatients, HRV was detected in 4.6 % of tested specimens, excluding influenza virus-positive patients (Hara et al , 2014). Despite being one of the most frequent respiratory virus infections for young children, most cases only experience mild symptoms.…”

Section: Discussionmentioning

confidence: 96%

Frequent respiratory viral infections in a young child in a 27‐month follow‐up study

et al. 2014

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Introduction:Viruses are major aetiological agents of acute respiratory infection in young children. Although many studies have reported detection and analysis of respiratory viruses in sporadic cases, there have been few follow-up studies of individuals. The purpose of this study was to investigate the frequency of respiratory viral infections in a young child and to examine the duration of viral genome detection in clinical specimens.Case presentation:A total of 284 nasal swabs were collected during symptomatic (196 specimens) and asymptomatic (88 specimens) periods of respiratory symptoms from a young female child (from 4 months to 31 months of age, who was admitted to a nursery school at 9 months). Multiplex real-time PCR for 19 respiratory viruses or subtypes was performed. One hundred and ninety-eight of the tested specimens were virus positive (69.7 %) (symptomatic periods, 149/196, 76.0 %; asymptomatic periods, 49/88, 55.7 %). Rhinovirus was the most frequently detected (26 times). Long durations of detection were observed for human coronavirus NL63 (30 days), rhinovirus (28 days) and human bocavirus 1 (22 days).Conclusion:Young children living in a group context have a high risk of respiratory virus infections, especially rhinovirus. In some instances, viral genomes were detectable for about 1 month by PCR.

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Three-Year Study of Viral Etiology and Features of Febrile Respiratory Tract Infections in Japanese Pediatric Outpatients

Abstract: Viral culture and real-time PCR assays were used together to identify causative pathogens in 83% of febrile outpatient children with RTI; specific viruses were associated with particular clinical diagnoses.

Cited by 19 publications

References 38 publications

Respiratory Viral Detections During Symptomatic and Asymptomatic Periods in Young Andean Children

Respiratory Viral Detections During Symptomatic and Asymptomatic Periods in Young Andean Children

Detection of respiratory viruses in gargle specimens of healthy children

Frequent respiratory viral infections in a young child in a 27‐month follow‐up study

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