Three-year's changes in glucose tolerance status in the Bellville South cohort: Rates and phenotypes associated with progression

Matsha, Tandi E.; Soita, David Jonah; Hassan, Mogamat Shafick; Hon, Gloudina Mary; Yako, Yandiswa Y; Kengne, André Pascal; Erasmus, Rajiv T

doi:10.1016/j.diabres.2012.10.018

Cited by 17 publications

(18 citation statements)

References 30 publications

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“…A consecutive sampling technique was used to recruit potential participants according to the following inclusion criteria: Individuals of mixed ancestry (defined in accordance to the South African Population Registration Act No. 30 of 1950, repealed in 1991), living in the Bellville area of the Western Cape Province, South Africa, with a minimum age of 18 years who signed the informed consent [15]. The exclusion criteria included individuals requiring prophylactic antibiotics, undergoing renal dialysis, with intellectual disabilities, with cancer, younger than 18 years, pregnant women, and those who were too ill or unable to sign the consent.…”

Section: The Samplementioning

confidence: 99%

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Prevalence of Oral Mucosal Lesions and Relation to Serum Cotinine Levels—Findings from a Cross-Sectional Study in South Africa

Pontes

Chikte

Kimmie-Dhansay

et al. 2020

IJERPH

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Oral mucosal lesions (OML) can decrease oral health-related quality of life and some have the potential to become malignant. The aim of the present study was to report the prevalence of OML in relation to age, sex, and serum cotinine levels in a population with mixed ancestry from South Africa. This study is part of the Cape Town Vascular and Metabolic Health (VHM) study, conducted between 2014–2016. Trained dental examiners assessed the oral mucosa for the presence of OML according to WHO criteria. In total, 1976 individuals were included in the study, being 1496 females (75.7%) and 480 males (24.3%) with average age of 49.5 years (SD = 15.3). In total, 262 lesions were detected in 252 participants (overall prevalence of 13%). Males had higher prevalence than females (14% vs. 9%, p = 0.008). Participants aged 25–34 had the highest prevalence rates (21%). Participants who had cotinine ≥15 ng/mL had higher prevalence of OML as compared to those with <15 ng/mL (15% vs. 5%, p < 0.001). Most common lesions were nicotine stomatitis (33%) and leukoplakia (19%). Age, male sex, and higher cotinine levels were associated with increased prevalence of OML.

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Section: The Samplementioning

confidence: 99%

“…A fasting blood sample was collected and transported to an accredited laboratory within 6 h of collection for processing. A chemiluminescent assay was used after blood samples had been processed, in order to measure serum cotinine levels (Immulite 1000, Siemens), as described previously [15].…”

Section: Serum Cotininementioning

confidence: 99%

Prevalence of Oral Mucosal Lesions and Relation to Serum Cotinine Levels—Findings from a Cross-Sectional Study in South Africa

Pontes

Chikte

Kimmie-Dhansay

et al. 2020

IJERPH

View full text Add to dashboard Cite

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“…3 Biological specimen repositories in SA are generated for a number of reasons and incentivized by a variety of stakeholders that are typically academic, government, and commercially driven, as is typically seen in more advanced science based economies. 4 Despite the scourges of HIV, TB, and now metabolic syndromes, 5,6 patient-driven advocacy groups supporting the collection of biological samples to accelerate discovery have not yet emerged as a powerful force on the landscape of South African biological research, as one has seen in more affluent global communities. 7 Typically, biobanks in SA are concerned with the storage of human, animal, and plant biodiversity biological specimens.…”

Section: Introductionmentioning

confidence: 99%

Challenges of Biobanking in South Africa to Facilitate Indigenous Research in an Environment Burdened with Human Immunodeficiency Virus, Tuberculosis, and Emerging Noncommunicable Diseases

Abayomi

Christoffels²,

Grewal³

et al. 2013

Biopreservation and Biobanking

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The high burden of infectious diseases and the growing problem of noncommunicable and metabolic disease syndromes in South Africa (SA) forces a more focused research approach to facilitate cutting-edge scientific growth and public health development. Increased SA research on these diseases and syndromes and the collection of associated biospecimens has ensured a plethora of biobanks created by individuals, albeit without the foresight of prospective and collective use by other local and international researchers. As the need for access to high-quality specimens in statistically relevant numbers has increased, so has the necessity for the development of national human biobanks in SA and across the Continent. The prospects of achieving sustainable centralized biobanks are still an emerging and evolving concept, primarily and recently driven by the launch of the H3Africa consortium, which includes the development of harmonized and standardized biobanking operating procedures. This process is hindered by a myriad of complex societal considerations and ethico-legal challenges. Efforts to consolidate and standardize biological sample collections are further compromised by the lack of full appreciation by national stakeholders of the biological value inherent in these collections, and the availability of high quality human samples with well-annotated data for future scientific research and development. Inadequate or nonexistent legislative structures that specifically regulate the storage, use, dispersal, and disposal of human biological samples are common phenomena and pose further challenges. Furthermore, concerns relating to consent for unspecified future uses, as well as access to information and data protection, are all new paradigms that require further consideration and public engagement. This article reviews important fundamental issues such as governance, ethics, infrastructure, and bioinformatics that are important foundational prerequisites for the establishment and evolution of successful human biobanking in South Africa.

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“…The study was conducted according to the code of ethics of the World Medical Association (Declaration of Helsinki). A detailed description of the research setting has been previously described [12, 13]. Briefly, Bellville South is predominantly a mixed ancestry township located in the northern suburb of Cape Town in the Tygerberg subdistrict.…”

Section: Methodsmentioning

confidence: 99%

Rare Mutations of Peroxisome Proliferator-Activated Receptor Gamma: Frequencies and Relationship with Insulin Resistance and Diabetes Risk in the Mixed Ancestry Population from South Africa

Vergotine

Kengne

Erasmus

et al. 2014

International Journal of Endocrinology

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Background. Genetic variants in the nuclear transcription receptor, PPARG, are associated with cardiometabolic traits, but reports remain conflicting. We determined the frequency and the clinical relevance of PPARG SNPs in an African mixed ancestry population. Methods. In a cross-sectional study, 820 participants were genotyped for rs1800571, rs72551362, rs72551363, rs72551364, and rs3856806, using allele-specific TaqMan technology. The homeostatic model assessment of insulin (HOMA-IR), β-cells function (HOMA-B%), fasting insulin resistance index (FIRI), and the quantitative insulin-sensitivity check index (QUICKI) were calculated. Results. No sequence variants were found except for the rs3856806. The frequency of the PPARG-His447His variant was 23.8% in the overall population group, with no difference by diabetes status (P = 0.215). The His447His allele T was associated with none of the markers of insulin resistance overall and by diabetes status. In models adjusted for 2-hour insulin, the T allele was associated with lower prevalent diabetes risk (odds ratio 0.56 (95% CI 0.31–0.95)). Conclusion. Our study confirms the almost zero occurrences of known rare PPARG SNPs and has shown for the first time in an African population that one of the common SNPs, His447His, may be protective against type 2 diabetes.

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Three-year's changes in glucose tolerance status in the Bellville South cohort: Rates and phenotypes associated with progression

Cited by 17 publications

References 30 publications

Prevalence of Oral Mucosal Lesions and Relation to Serum Cotinine Levels—Findings from a Cross-Sectional Study in South Africa

Prevalence of Oral Mucosal Lesions and Relation to Serum Cotinine Levels—Findings from a Cross-Sectional Study in South Africa

Challenges of Biobanking in South Africa to Facilitate Indigenous Research in an Environment Burdened with Human Immunodeficiency Virus, Tuberculosis, and Emerging Noncommunicable Diseases

Rare Mutations of Peroxisome Proliferator-Activated Receptor Gamma: Frequencies and Relationship with Insulin Resistance and Diabetes Risk in the Mixed Ancestry Population from South Africa

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