Three useful bromimetric methods for the determination of salbutamol sulfate

Basavaiah, K.; Prameela, H. C.

doi:10.1007/s00216-003-1972-4

Cited by 27 publications

(30 citation statements)

References 15 publications

(13 reference statements)

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“…[28][29][30][31][32] In recent years, acidified solution of bromate and bromide and dyes have been adapted to the quantification of several pharmaceutical substances. [19][20][21][22][23][24][25] In the proposed spectrophotometric methods, the ability of bromine to cause bromination of AST and irreversibly destroy methyl orange and indigo carmine dyes to colourless products in acid medium has been used. Both spectrophotometric methods are based on the bromination of AST by a measured excess of in situ generated bromine and subsequent determination of the unreacted bromine by treating with methyl orange or indigo carmine and measuring the absorbance at 520 nm or 610 nm.…”

Section: Methods Developmentmentioning

confidence: 99%

Simple and practicable methods for the determination of astemizole in pharmaceuticals using bromate-bromide and two dyes

Nagegowda¹,

Basavaiah²

2005

J. Braz. Chem. Soc.

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Um método titrimétrico e dois espectrofotométricos, simples e sensíveis, são descritos para a determinação de astemizola (AST) em drogas comerciais e formulações. Os métodos usam a mistura brometo-bromato e dois pigmentos, laranja de metila e índigo carmim. Na titrimetria (Método A), astemizola é tratada com uma mistura ácida de brometo-bromato em excesso conhecido e depois do término completo da reação de bromatação, o excesso de bromo é reversamente titulado iodometricamente. Nos métodos espectrofotométricos, o excesso de bromo é estimado após o tratamento com uma quantia determinada de laranja de metila (Método B) ou índigo carmim (Metodo C), e as mudanças de absorbância medidas em 520 e 610 nm, respectivamente. Em todos os métodos, a quantidade de bromato reagido corresponde à quantidade na droga. O método tritrimetrico é aplicável na faixa de 4-16 mg e os cálculos são feitos numa relação 1:0,666 (AST:bromato). Nos espectrofotométricos, a curva de calibração é linear entre 0,5 e 4,0 µg mL (Método B) e entre 1,25 e 12,5 µg mL (Método C), com valores de absortividade molar de 6,6x10, respectivamente. Os limites de detecção e quantificação são apresentados para os Métodos B e C. A avaliação estatística foi examinada pela precisão da determinação intra-e inter-diária. Os métodos são aplicáveis na determinação de AST em cápsulas e xaropes, e os resultados são concordantes com os apresentados em rótulo. A exatidão e confiabilidade dos métodos foram testadas pela determinação paralela por um método de referência, com limite de confiança de 95% para valores t-Student e F-Student, e por estudos de recuperação por adição padrão.One titrimetric and two spectrophotometric methods, which are simple and sensitive, are described for the determination of astemizole (AST) in bulk drug and formulations. The methods use bromatebromide mixture and two dyes, methyl orange and indigo carmine. In titrimetry (Method A), astemizole is treated with a known excess of bromate-bromide mixture in acid medium and after the bromination reaction is ensured to be complete, the residual bromine is back-titrated iodometrically. In spectrophotometric methods, the excess of bromine is estimated by treating it with a fixed amount of either methyl orange (Method B) or indigo carmine (Method C) and measuring the change in absorbance either at 520 or 610 nm. In all the methods, the amount of bromate reacted corresponds to the drug content. Titrimetric method is applicable over 4-16 mg range and the calculations are based on a 1:0.666 (AST: bromate) reacting ratio. In spectrophotometry, the calibration graph is found to be linear over 0.5-4.0 µg mL -1 (Method B) and 1.25 -12.5 µg mL -1 (Method C) with molar absorptivity values of 6.6 x 10 4 L mol -1 cm -1 and 2.1 x 10 4 L mol -1 cm -1, respectively. The limits of detection and quantification are reported for methods B and C. The statistical evaluation of the methods was examined by determining intra-day and inter-day precision. The methods were applied to the determination of AST in tablets and syrup...

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Section: Methods Developmentmentioning

confidence: 99%

Simple and practicable methods for the determination of astemizole in pharmaceuticals using bromate-bromide and two dyes

Nagegowda¹,

Basavaiah²

2005

J. Braz. Chem. Soc.

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“…Titration is a quantitative analysis method used to determine the concentration of many active pharmaceutical ingredients such as tetraphenylborate sodium, phenothiazine compounds, acetaminophen, captopril, ascorbic acid, albendozole, sparfloxacin, salbutamol sulfate, montelukast sodium, phenylephrine hydrochloride, candesartan cilexetil [7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Status of Hydrogen Peroxide Solution 10 V in Commercialized Samples

Mn¹,

Ac²,

Hrn³

2017

Pharm Anal Acta

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Hydrogen peroxide (H 2 O 2 ) is one of the most powerful oxidants used in many sectors. Analytical method such as titration by permanganometry is used to maintain the quality of products containing H 2 O 2 . Thus, the objective of this work was to evaluate commercial samples of H 2 O 2 10 V by permanganometry. A difference of almost 3 volumes was found in the analysis of the samples. These results can be real or assigned to the potassium permanganate solution, not automation of the results and/or instability of the H 2 O 2 solutions, for example. The main issue is, in addition to alerting the consumers to adequate storage of H 2 O 2 solutions, to alert the scientific community to the need for concomitant analysis methods for unstable products such as H 2 O 2 10 V solutions in order to avoid doubts on the results and make the manufacturers aware of these quality tests.

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“…The methods utilize bromate-bromide mixture and methyl orange and indigo carmine as reagents, which have successfully been used for the sensitive spectrophotometric determination of many bioactive substances [10][11][12][13][14][15][16][17][18] . The proposed methods have the advantages of speed and simplicity besides being accurate and precise, and can be adopted by the pharmaceutical laboratories for industrial quality control.…”

Section: Introductionmentioning

confidence: 99%

New Sensitive Spectrophotometric Methods for the Determination of Raloxifene Hydrochloride in Pharmaceuticals Using Bromate‐Bromide,Methyl Orange and Indigo Carmine

Basavaiah

Kumar

2006

Journal of Chemistry

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Abstract:Two new sensitive spectrophotometric methods are proposed for the determination of raloxifene hydrochloride (RLX) using bromate-bromide mixture and two dyes, methyl orange and indigocarmine, as reagents. The methods entail the addition of a known excess of bromate-bromide mixture to RLX in hydrochloric acid medium followed by determination of residual bromine by reacting with a fixed amount of either methyl orange and measuring the absorbance at 520 nm (Method A) or indigo carmine and measuring the absorbance at 610 nm (Method B). In both methods, the amount of bromine reacted corresponds to the amount of RLX. The absorbance is found to increase linearly with concentration of RLX. Under the optimum conditions, RLX could be assayed in the concentration range 0.1-2.0 and 0.5-6.0 µg mL -1 by method A and method B, respectively. The apparent molar absorptivities are calculated to be 1.9x10 5 and 4.5x10 4 L mol -1 cm -1 for method A and method B, respectively, and the corresponding Sandell sensitivity values are 0.003 and 0.011 µg cm -2 . The limits of detection and quantification are also reported for both methods. Intra-day and inter-day precision and accuracy of the developed methods were evaluated as per the current ICH guidelines. The methods were successfully applied to the assay of RLX in its tablet formulation and the results were compared with those of a reference method by calculating the Student's t-value and F-value. No interference was observed from common tablet adjuvants. The accuracy and reliability of the methods were further ascertained by recovery experiments via standard-addition procedure.

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Three useful bromimetric methods for the determination of salbutamol sulfate

Cited by 27 publications

References 15 publications

Simple and practicable methods for the determination of astemizole in pharmaceuticals using bromate-bromide and two dyes

Simple and practicable methods for the determination of astemizole in pharmaceuticals using bromate-bromide and two dyes

Status of Hydrogen Peroxide Solution 10 V in Commercialized Samples

New Sensitive Spectrophotometric Methods for the Determination of Raloxifene Hydrochloride in Pharmaceuticals Using Bromate‐Bromide,Methyl Orange and Indigo Carmine

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