Three new monoterpenoid indole alkaloids fromVinca major

Abstract

Three new monoterpenoid indole alkaloids, 19-hydroxyl-10-methoxy-19, 20-dihydrovinorine (1), 19-O-acetyl-10-methoxy-19, 20-dihydrovinorine (2), and 19, 21α-dihydroxyl-10-methoxy-19, 20-dihydrovinorine (3), along with five known analogues (4-8), were isolated from the whole plants of Vinca major. The new structures were elucidated by extensive NMR and MS analysis and comparison with known compounds. In addition, compounds 1-3 were evaluated for their cytotoxicities against five human cancer cell lines.

An Update on Cyclohepta[b]indoles

“…[13] In 2016, Zhao et al disclosed the isolation of the hexahydrocyclohepta[b]indole alkaloids 5, 6 and 7 from Vinca major. [14] The vinorine-type cyclohepta [b]indole alkaloids are structurally characterized by the ajmaline core carbon structure.…”

Monoterpene Indole Alkaloids with Cav3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus

“…In recent years, some new and bioactive MIAs were still reported from this plant [11][12][13][14][15][16][17]. In our continuing search for structurally unique and pharmaceutically interesting MIAs from medicinal plants [18][19][20][21][22], a phytochemical study of the twigs and leaves of C. roseus was undertaken and led to the identification of two new MIAs, catharanosines A (1) and B (2), and six known analogues (Figure 1). Compound 2 was found to represent an unprecedented aspidosperma-type alkaloid with a piperidine moiety at C-10.…”