Articles you may be interested inModel simulations of the adsorption of statherin to solid surfaces: Effects of surface charge and hydrophobicity Polymer translocation through a nanopore induced by adsorption: Monte Carlo simulation of a coarse-grained model Monte Carlo simulations ͑MC͒ were used to study the adsorption of a negatively charged peptide ͑ASP-ASP-ILE-ILE-ASP-ASP-ILE-ILE͒ dissolved in water onto charged surfaces and in vacuum onto neutral surfaces. When the peptide was placed between two charged surfaces, it always adsorbed sideways onto the positively charged surface even when it was initially positioned at the negatively charged one. The structure of water around the peptide significantly changed upon adsorption. The peptide adsorbed on a neutral surface heads-on. The subsequent addition of water does not seem to affect the location and orientation of the peptide at the surface. Our results indicate that dehydration of the peptide upon adsorption always happens to the residues that are closest to the surface independently of the surface's charge.
The antimicrobial activities of emodin and its derivatives (anthraquinone, alizarin, and alizarin-3-methyliminodiacetic acid) were evaluated using a paper disc diffusion method against foodborne bacteria (Bacillus cereus, Listeria monocytogenes, Staphylococcus intermedius, Salmonella typhimurium and Shigella sonnei). Emodin isolated from C. tora seeds has an antimicrobial activity against Bacillus cereus, followed by alizarin-3-methyliminodiacetic acid (13.0±2.5 mm) and alizarin (11.5±1.2 mm). Furthermore, emodin showed the antimicrobial activity against S. sonnei and S. typhimurium. In conclusion, C. tora seed and its active component derivatives are useful for the development of natural products on food supplemental agents and pharmaceuticals.
Three new pyridine type alkaloids, (−)-vinmajpyridines A–C (1–3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3# and GITC-18#), glioblastoma cell lines (U-87MG and T98G), and lung cancer cell line A-549, but none of them was active at 20 μg/mL concentration.Electronic supplementary materialThe online version of this article (doi:10.1007/s13659-017-0137-7) contains supplementary material, which is available to authorized users.
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