Three new guaiane-type sesquiterpenoids and a monoterpenoid from <i>Litsea lancilimba</i> Merr

Muhammad, Ishaq; Xiao, Yong; Hassan, Syed Shams ul; Xue, Xiao; Yan, Shaomin; Guo, Yuanqiang; Ma, Xian-peng; Jin, Hui‐Zi

doi:10.1080/14786419.2020.1853727

Cited by 15 publications

(7 citation statements)

References 16 publications

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“…Therefore, the planar structure of 1 was suggested as 2-oxo-4,10,11-trihydroxyguaia-1(5)-ene, which had one more hydroxy group at C-10 compared to lancilimbnoid C (figures S1-S8). [9] The relative configuration of compound 1 was determined by NOESY spectrum (figure 2). Because of the flexibility of cycloheptene-ring, conformational analysis of backbone structure (bicyclo[5.3.0]dec-1(5)-en-2-one) of 1 was performed.…”

Section: Resultsmentioning

confidence: 99%

“…[ 7,8 ] A set of carbon chemical shifts of δ C 52.8 (CH 2 )/76.9 (C)/177.9 (C)/143.8 (C)/208.1 (C=O) were very similar to those of lancilimbnoid C, suggesting compound 1 is a guaiane‐type sesquiterpenoid. [ 9 ] In the COSY spectrum, H 2 ‐6 correlated with H‐7, H‐7 correlated with H 2 ‐8, and H 2 ‐8 correlated with H 2 ‐9. This evidence indicated the structural connection from C‐6 to C‐9.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the planar structure of 1 was suggested as 2‐oxo‐4,10,11‐trihydroxyguaia‐1(5)‐ene, which had one more hydroxy group at C‐10 compared to lancilimbnoid C (figures S1‐S8). [ 9 ]…”

Section: Resultsmentioning

confidence: 99%

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A new sesquiterpene and lignans from the roots of Kadsura induta

Hien,

Trang,

Thao

et al. 2023

Vietnam Journal of Chemistry

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One new sesquiterpene, (4S,7R,10S)‐2‐oxo‐4,10,11‐trihydroxyguaia‐1(5)‐ene (1), and five lignans, kadsuralignan J (2), isovaleroylbinankadsurin A (3), schizandrin O (4), futokakadsurin C (5), and arisantetralone (6) were isolated from the roots of Kadsura induta. Their chemical structures were revealed by MS, 1D and 2D NMR spectra in comparison with the reported data. The absolute configuration of compound 1 was determined by calculation of its theoretical ECD spectra and compared with the experimental results.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A new sesquiterpene and lignans from the roots of Kadsura induta

Hien,

Trang,

Thao

et al. 2023

Vietnam Journal of Chemistry

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“…With the introduction of sophisticated chromatographic techniques, there is a growing desire to create and develop simple, quick, convenient, and cost-effective standardization methods [ 16 ]. HPLC is a sensitive and precise tool that is frequently used for the qualitative assessment of plant extracts and their derived product/formulation [ 17 ]. A typical HPLC chromatogram of the crude extract is given in Figure 2 , while the identified possible phytochemical compounds are given in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

Biological Evaluation, Phytochemical Screening, and Fabrication of Indigofera linifolia Leaves Extract-Loaded Nanoparticles

et al. 2022

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Indigofera linifolia is a medicinally important plant, and by virtue of its rich phytochemical composition, this plant is widely used as essential component in traditional medication systems. Due to its wide range of medicinal applications, the extract-loaded chitosan (Ext+Ch), extract-loaded PEG (Ext+PEG), and extract-loaded locust bean gum (Ext+LGB) nanoparticles (NPs) were prepared in the present study. The prepared NPs were then evaluated for their antibacterial, antioxidant, and antidiabetic potentials. Antibacterial activities of the crude extract and the synthesized NPs were performed following standard procedures reported in the literature. The antioxidant capabilities of extract and NPs were evaluated using DPPH free radical scavenging assay. The antidiabetic potential of the samples was evaluated against α-amylase and α-glucosidase. Ext+PEG NPs showed more potent antibacterial activity against the selected strains of bacteria with the highest activity against Escherichia coli. The lowest antibacterial potential was observed for Ext+LGB NPs. The Ext+LGB NPs IC50 value of 39 μg/mL was found to be the most potent inhibitor of DPPH free radicals. Ext+LGB NPs showed a greater extent of inhibition against α-glucosidase and α-amylase with an IC50 of 83 and 78 μg/mL, whereas for the standard acarbose the IC50 values recorded against the mentioned enzymes were 69 and 74 μg/mL, respectively. A high concentration of phenolics and flavonoids in the crude extract was confirmed through TPC and TFC tests, HPLC profiling, and GC–MS analysis. It was considered that the observed antibacterial, antidiabetic, and antioxidant potential might be due the presence of these phenolics and flavonoids detected. The plant could thus be considered as a potential candidate to be used as a remedy of the mentioned health complications. However, further research in this regard is needed to isolate the exact responsible compounds of the observed biological potentials exhibited by the crude extract. Further, toxicity and pharmacological evaluations in animal models are also needed to establish the safety or toxicity profile of the plant.

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“…In scientific developments, there have been numerous studies on medicinal plants worldwide due to their therapeutic efficacy. Medicinal plants are an important source of lead compounds for developing new drugs that are highly effective, have no side effects, and are economically feasible [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. According to studies conducted by the World Health Organization, over 80% of the world’s population relies on medicinal herbs for the treatment of various ailments.…”

Section: Introductionmentioning

confidence: 99%

HPLC, FTIR and GC-MS Analyses of Thymus vulgaris Phytochemicals Executing In Vitro and In Vivo Biological Activities and Effects on COX-1, COX-2 and Gastric Cancer Genes Computationally

et al. 2022

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Medicinal plants have played an essential role in the treatment of various diseases. Thymus vulgaris, a medicinal plant, has been extensively used for biological and pharmaceutical potential. The current study was performed to check the biopotential of active biological compounds. The GC-MS analysis identified 31 compounds in methanolic crude extract, among which thymol, carvacrol, p-cymene, and eugenol are the main phytoconstituents present in T. vulgaris. The HPLC analysis quantified that flavonoids and phenolic acids are present in a good concentration in the active fraction of ethyl acetate and n-butanol. FTIR confirmed the presence of functional groups such as phenols, a carboxylic group, hydroxy group, alcohols, and a benzene ring. Among both fractions, ethyl acetate showed high antioxidant activity in the DPPH (84.1 0.88) and ABTS (87.1 0.89) assays, respectively. The anti-inflammatory activity of the fractions was done in vitro and in vivo by using a carrageenan-induced paw edema assay, while the hexane-based extract showed high anti-inflammatory activity (57.1 0.54) in a dose-response manner. Furthermore, the lead compound responsible for inhibition in the denaturation of proteins is thymol, which exhibits the highest binding affinity with COX1 (−6.4 KJ/mol) and COX2 (−6.3 KJ/mol) inflammatory proteins. The hepatotoxicity analysis showed that plant-based phytoconstituents are safe to use and have no toxicity, with no necrosis, fibrosis, and vacuolar degeneration, even at a high concentration of 800 mg/kg body weight. Furthermore, the in silico analysis of HPLC phytochemical compounds against gastric cancer genes showed that chlorogenic acid exhibited anticancer activity and showed good drug-designing characteristics. Thrombolysis and hemolysis are the major concerns of individuals suffering from gastric cancer. However, the T. vulgaris fractions showed thrombolysis from 17.6 to 5.4%; similarly, hemolysis ranged from 9.73 to 7.1% at a concentration of 12 mg/mL. The phytoconstituents present in T. vulgaris have the potential for multiple pharmacological applications. This should be further investigated to isolate bioactive compounds that can be used for the treatment of different ailments.

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Three new guaiane-type sesquiterpenoids and a monoterpenoid from Litsea lancilimba Merr

Cited by 15 publications

References 16 publications

A new sesquiterpene and lignans from the roots of Kadsura induta

A new sesquiterpene and lignans from the roots of Kadsura induta

Biological Evaluation, Phytochemical Screening, and Fabrication of Indigofera linifolia Leaves Extract-Loaded Nanoparticles

HPLC, FTIR and GC-MS Analyses of Thymus vulgaris Phytochemicals Executing In Vitro and In Vivo Biological Activities and Effects on COX-1, COX-2 and Gastric Cancer Genes Computationally

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