Three new geranyl aurones from the leaves of Artocarpus altilis

Thanh, Nguyễn Thị; Hải, Nguyễn Xuân; Dang, Phu Hoang; Trong, Phan Nguyen Huu; Nhan, Nguyen Trung

doi:10.1016/j.phytol.2012.06.014

Cited by 23 publications

(8 citation statements)

References 8 publications

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“…In contrast with the known standard kojic acid, an excellent inhibitor of mushroom tyrosinase, 4,6,4′-trihydroxyaurone showed even superior inhibitory results. 107,108 …”

Section: Flavonoidsmentioning

confidence: 99%

“…N. T. Mai and his colleagues (2012) have reported three new aurones (compounds 10, 12, and 15) isolated from a plant, Artocarpus altilis (Moraceae), which is broadly distributed over the tropical regions of Asia. 109 The isolated compounds were tested for their tyrosinase inhibitory activity ( Table 3 ). The assay was carried out at five different concentrations ranging from 1 to 100 μM for tyrosinase inhibition.…”

Section: Flavonoidsmentioning

confidence: 99%

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Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: a systematic review

et al. 2021

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“…In contrast with the known standard kojic acid, an excellent inhibitor of mushroom tyrosinase, 4,6,4′-trihydroxyaurone showed even superior inhibitory results. 107,108 …”

Section: Flavonoidsmentioning

confidence: 99%

Section: Flavonoidsmentioning

confidence: 99%

Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: a systematic review

et al. 2021

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“…The UV/Vis spectrophotometer analysis results showed maximum absorption at 367 nm (Figure 1), which indicated the presence of aurone structure. [17][18][19] The compound had the molecular formula C15H10O7 with molecular weight of 302.24 (M+H + = 303.20 m/z ) (Figure 2). Infrared spectrum analysis showed a broad absorption with a strong intensity at 3257.18 cm -1 , indicating the presence of the hydroxy group.…”

Section: Isolation and Characterisationmentioning

confidence: 99%

“…In the COSY analysis, there was a correlation between protons H5"-H6" and H5"'-H7"', which supports the presence of benzene structure in the basic structure of aurone. [17][18][19] (Figure 5). HMBC analysis showed a correlation between the proton signal of methine sp 2 at δH 7.673 (H-2") to carbon atoms at δC 147.706 (C-3"), δC 145.067 (C-4"), and δC 119.976 (C-6").…”

Section: Isolation and Characterisationmentioning

confidence: 99%

Antibacterial, Antioxidant, and Cytotoxic Flavonoid Compound from Sterculia Quadrifida Leaves

2021

TJNPR

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The genus Sterculia generally grows in the tropics and sub-tropics. 1 the genus had many secondary metabolites such as alkaloids, saponins, triterpenoids, tannins, and phenolics. 2 Several species in this genus are traditionally used to treat ulcers, diarrhoea, fever, stroke, diabetes, and inflammation. 3 Sterculia quadrifida, a plant called "Faloak" in Indonesia, has a significant role in folk medicine, especially for infectious diseases, as anti-hepatitis, and anticancer. 4 However, studies of S. quadrifida plants are still limited. Only a few studies have been conducted in the last decade investigating the phytochemical content of S. quadrifida plants and isolating triterpenoids and anthraquinone compounds. 5,6 Some of these compounds show pharmacological effects, such as anti-hepatitis 7 , immunostimulant, antioxidant, anti-cancer, and antibacterial activities. 7-9 Among all compounds, flavonoids have the potential to be used as anti-infective, antioxidant, and anti-cancer agent. 10 Therefore, this study aimed to isolate the active antibacterial, antioxidant, and anti-cancer compounds from the methanol leaves extract of S. quadrifida using chromatographic techniques.

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“…It is effective in controlling postprandial hyperglycaemia and prevents complications associated with type-II diabetes, such as microvascular (i.e., retinal, renal, and possibly neuropathic), macrovascular (i.e., coronary and peripheral vascular), and neuropathic (i.e., autonomic and peripheral) complications [ 3 , 4 ]. Previously, we reported that the methanolic extracts of Embelia ribes , Oroxylum indicum , and Artocarpus altilis exhibited significant inhibitory activity on α-glucosidase [ 5 – 8 ]. In a part of our continued research on the screening of medicinal plants of different origins, we also found that the n -hexane extract of the bark of M. mekongensis showed strong α-glucosidase inhibitory activity with IC 50 value of 1.71 µg/mL.…”

Section: Introductionmentioning

confidence: 99%

α-Glucosidase inhibitors from the bark of Mangifera mekongensis

Nguyen

et al. 2016

Chemistry Central Journal

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BackgroundMangifera mekongensis (Anacardiaceae) is cultivated for its edible fruit and has been used in traditional Vietnamese medicine for its anti-aging properties and for treating diabetes, vermifuge, and dysentery. As part of a search for biologically active compounds with reduction of the rate of glucose absorption, a screening has been initiated to evaluate natural product extracts for the inhibition of enzyme α-glucosidase. A n-hexane extract of the bark of M. mekongensis showed strong α-glucosidase inhibitory activity with IC50 value of 1.71 µg/mL. Thus, the constituents of this plant were examined.ResultsTwo new steroids named mekongsterol A (1) and mekongsterol B (2), were isolated from the n-hexane extract of the bark of M. mekongensis (Anacardiaceae), together with seven known compounds (3–9). Their chemical structures were elucidated on the basis of spectroscopic data. All compounds possessed significant α-glucosidase inhibitory activity in a concentration-dependent manner, except for 3 and 4. Compounds 1, 2, 5–9 showed more potent inhibitory activity, with IC50 values ranging from 1.2 to 112.0 µM, than that of a positive control acarbose (IC50, 214.5 µM).ConclusionsThese results suggested that the traditional use of the bark of M. mekongensis for the treatment of diabetes diseases in Vietnam may be attributable to the α-glucosidase inhibitory activity of its steroid and cycloartane constituents.Electronic supplementary materialThe online version of this article (doi:10.1186/s13065-016-0193-9) contains supplementary material, which is available to authorized users.

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Three new geranyl aurones from the leaves of Artocarpus altilis

Cited by 23 publications

References 8 publications

Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: a systematic review

Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: a systematic review

Antibacterial, Antioxidant, and Cytotoxic Flavonoid Compound from Sterculia Quadrifida Leaves

α-Glucosidase inhibitors from the bark of Mangifera mekongensis

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