Three new flavonoid glycosides from the aerial parts of Allium sativum L. and their anti-platelet aggregation assessment

Abstract

Three new flavonoid glycosides, Dasuanxinoside F-H (1-3), were isolated from the aerial parts of Allium sativum, together with eight known compounds which were firstly reported in this plant, including three flavonoid glycosides (4-6) and five phenylethanoid glycosides (7-11). Their structures were identified by UV-vis, IR, 1D and 2D NMR spectra, as well as HR-ESI-MS analyses. The inhibitory effect of the isolated compounds on platelet aggregation induced by adenosine diphosphate (ADP) was evaluated in vitro. The results showed that most compounds displayed different degrees of inhibition. Among them, 2, 5, 8 and 9 exhibited the strongest activity on platelet aggregation.

Research Progress on Extraction and Detection Technologies of Flavonoid Compounds in Foods

“…The result showed that a 70% ethanol extract of sea buckthorn juice had an average of 1.3 and 1.6 times greater TPC and TFC values, respectively, than other extracts. Hu et al [89] isolated three new flavonoid glycosides and eight known compounds from the aerial parts of Allium sativum and identified the structure of these compounds in the extracts using ultraviolet-visible (UV-Vis), infrared (IR), nuclear magnetic resonance (NMR), and high-resolution electrospray ionization-mass spectrometry (HR-ESI-MS). The results showed that nine components were active, which revealed the pharmacodynamic material basis of the aerial parts of A. sativum on platelet aggregation.…”

Natural Sources of Inhibition of Adenosine Diphosphate-Induced Platelet Aggregation

“…Hu and colleagues were successfully able to isolate 3 novel flavonoid glycosides in addition to the 8 already discovered phytocompounds from Allium sativum commonly known as garlic. They identified that these compounds posess ADP-induced platelet aggregation blocking ability where 4 compounds exhibited the greatest thrombolytic potential (Hu et al 2022). The antioxidant and anti-neoplastic effects of safflower have already been established.…”

New Ionone Glycosides from the Aerial Parts of Allium sativum and Their Anti-Platelet Aggregation Activity

“…sativum. The investigation led to the isolation of two new (1-2) together with thirteen known (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) compounds. Their structures were identified by high resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) spectra, as well as comparison with reference data.…”

“…The drug, which is called Da Suan, was first recorded in Mingyi Bielu more than 1800 years ago and is still included in Chinese pharmacopoeia (2020 edition), with the indications of dysentery control, detumescence and as an insecticide 1 . A lot of research has been conducted worldwide since the 1970 s on garlic and more than 130 compounds have been reported including organic sulfur compounds 2 , 3 , steroidal saponins 4 , 5 , flavonoids 6 , 7 , amino acids, pyranone derivatives 8 , phenols 6 , cerebrosides 9 , volatile oil, vitamins, polysaccharides and protein 10 . The bulbs of A. sativum are clinically used to treat cardiovascular diseases, digestive system diseases, infectious diseases, urinary system diseases and other diseases 11 , 12 .…”

“…However, there are only few studies focussing on the aerial parts, which are normally discarded during harvest. In this study, two new ionone glycosides, dasuanxinosides D and E (1, 2), are isolated from the aerial parts together with 13 known compounds including alkanes derivatives and alkyl glycosides (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), which are reported for the first time from this plant. Their structures are identified by extensive NMR and HRMS analyses.…”