Three New Cytochalasins Produced by an Endophytic Fungus in the Genus <i>Rhinocladiella</i>

Wagenaar, M.; Corwin, Jennifer; Strobel, Gary A.; Clardy, Jon

doi:10.1021/np0002942

Cited by 109 publications

(54 citation statements)

References 16 publications

(24 reference statements)

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“…Cytochalasins have been reported as cytotoxic agents from the endophytic fungus Rhinocladiella sp. associated with the perennial twining vine Tripterygium wilfordii (Wagenaar et al 2000 ). It was previously reported from this same fungal isolate (Lee 1995 ).…”

Section: Alkaloidssupporting

confidence: 62%

Endophytic Fungi: Novel Sources of Anticancer Molecules

Kumar

Rai

Gaur

et al. 2013

Advances in Endophytic Research

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Cancer is an enormous global health burden, touching every region of the world. The term "anticancer" is based on the assessment of the authors of the paper of the cytotoxicity of each compound against specifi c cancer cell lines. Endophytic fungi, fungi that are residing asymptomatically in internal tissues of all higher plants, are of growing interest as promising sources of biologically active agents. Endophytic fungi are one of the most creative groups of secondary metabolite producers that play important biological roles for human life. This chapter mainly focuses on endophytic fungi, which produce anticancer bioactive compounds such as paclitaxel, podophyllotoxin, camptothecin, vinblastine, hypericin, and diosgenin. The uniqueness of the endophytic community of fungi is stressed as a promising source of novel compounds with anticancer activity. Endophytes represent a dependable source of specifi c secondary metabolites and can be manipulated both physicochemically and genetically to increase yields of desired metabolites and to produce novel analogues of active metabolites.

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Section: Alkaloidssupporting

confidence: 62%

Endophytic Fungi: Novel Sources of Anticancer Molecules

Kumar

Rai

Gaur

et al. 2013

Advances in Endophytic Research

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“…Another compound from ergochrome class, i.e., secalonic acid D, a mycotoxin, isolated from the mangrove endophytic fungus also exhibits a good cytotoxic activity on HL60 and K562 cells by inducing leukemia cell apoptosis [52]. Wagenaar et al [53] studied Rhinocladiella sp. inhabiting Tripterygium wilfordii and reported three novel cytochalasins: cytochalasin H, cytochalasin J and epoxycytochalasin H along with a known compound cytochalasin E. These compounds have been identiied as 22-oxa-12-cytochalasins and have antitumor activity.…”

Section: An Overview Of Anticancer Agents From Endophytic Fungimentioning

confidence: 99%

Endophytic Fungi as Alternative and Reliable Sources for Potent Anticancer Agents

Omeje¹,

Ahomafor²,

Onyekaba³

et al. 2017

Natural Products and Cancer Drug Discovery

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In comparison with other natural sources like plants, highly diverse microorganisms are narrowly explored, especially with respect to their limitless potentials as repositories of exceptionally bioactive natural products. Of these organisms, fungi inhabiting tissues of plant in a noninvasive relationship (endophytic fungi) have proven undeniably useful and unmatchable as sources of potent bioactive molecules against several diseases such as cancer and related ailments. In general terms, endophytic fungi are highly prevalent organisms found in the tissue (intracellular or intercellular) of plants and at least for reasonable portion of their lives. It has been proven that virtually every plant, irrespective of habitat and climate, plays host to wide varieties of endophytes. Endophytic fungi produce metabolites produced by diferent biosynthetic pathways to that of the host plant, and this robustness equips them to synthesize unlimited structural entities and scafolds of diverse classes. Interestingly too, the cohabitation/culture of these fungi with certain bacteria ofers even stronger hopes for anticancer drug discovery. The endless need for potent drugs has necessitated the search of bioactive molecules from several sources, and endophytic fungi appear to be a recipe. This chapter is an atempt to present the current trend of research with these very promising organisms.

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“…'309' colonizing in Tripterygium wilfordii (family Celastraceae), a viney medicinal plant used to treat arthritis and other autoimmune diseases 78 . In addition to secondary metabolites from endophytic fungi, some extracts of fermentation broth of endophytes were shown to be toxic to cancer cells.…”

Section: Antitumor Substancesmentioning

confidence: 99%

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2014

IJPSR

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Three New Cytochalasins Produced by an Endophytic Fungus in the Genus Rhinocladiella

Cited by 109 publications

References 16 publications

Endophytic Fungi: Novel Sources of Anticancer Molecules

Endophytic Fungi: Novel Sources of Anticancer Molecules

Endophytic Fungi as Alternative and Reliable Sources for Potent Anticancer Agents

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