Three new compounds from the roots of Juglans mandshurica Maxim.

Li, Jing; Xu, Ping; Zou, Zhen‐Xing; Zou, Hui; Long, Hong‐Ping; Tan, Lei-Hong; Liu, Ruihuan; Wang, Yikun; Xu, Kang‐Ping; Tan, Gui‐Shan

doi:10.1016/j.phytol.2017.03.014

Cited by 13 publications

(4 citation statements)

References 20 publications

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“…For the research on the active principles of J. mandshurica , numerous compounds, including tannins [ 7 , 8 ], flavonoids [ 9 , 10 ], naphthalenes [ 11 ], diarylheptanoids [ 12 ], organic acids [ 13 ], anthracenes [ 14 ], triterpenes [ 15 ], lignans [ 16 ] and phenylpropanoids [ 17 ], were isolated from this plant. Some of the compounds isolated have been reported to have growth inhibitory effects on human cancer cell lines (HepG2 hepatoma cells, HL-60 leukemia cells, lung carcinoma cells, SGC-7901 gastric cancer cells, etc.)…”

Section: Introductionmentioning

confidence: 99%

Identification of Polar Constituents in the Decoction of Juglans mandshurica and in the Medicated Egg Prepared with the Decoction by HPLC-Q-TOF MS2

Wang

et al. 2017

Molecules

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As a folk medicinal plant, Juglans mandshurica has been used for the treatment of cancer in China and Korea. Traditionally, J. mandshurica is decocted together with chicken eggs. Both the decoction and medicated eggs possess anti-tumor properties. Clarifying the constituents of the decoction and absorbed by the medicated eggs is essential for the investigation of the active principles of J. mandshurica. Herein, the medicated eggs were prepared by decocting raw chicken eggs, having unbroken shells, with the decoction of J. mandshurica. A systematic investigation of the chemical profile of the J. mandshurica decoction and the medicated egg extraction was conducted by HPLC-Q-TOF-MS2. In total, 93 peaks, including 45 tannins, 14 naphthalene derivatives, 17 organic acids, 3 diarylheptanoids, 4 lignans, 3 anthraquinones, 1 flavonoid glycoside, 3 amino acids, and 3 nitrogenous compounds, were tentatively identified in the decoction. In the medicated egg extraction, 44 peaks including 11 organic acids, 3 amino acids, 3 nitrogenous compounds, 8 naphthalene derivatives, 3 diarylheptanoids, 15 tannins, and 1 lignan were tentatively identified. The chemical profile presented provided a detailed overview of the polar chemical constituents in J. mandshurica and useful information for the research of bioactive compounds of this plant.

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Section: Introductionmentioning

confidence: 99%

Identification of Polar Constituents in the Decoction of Juglans mandshurica and in the Medicated Egg Prepared with the Decoction by HPLC-Q-TOF MS2

Wang

et al. 2017

Molecules

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“…Local and traditional usages of J. mandshurica in China can be traced back to the Han dynasty over 2000 years ago. Available literature shows that J. mandshurica has been used as popular herbal medicine and food by ethnic groups in many regions of the world, especially in Asian countries, such as China, Japan, and Korea to treat the various diseases like leucorrhoea, diarrhea, gastritis, leukopenia, dermatosis, and uterine prolapse ( Liu et al, 2004a ; Li et al, 2005 ; Xu et al, 2010 ; Park et al, 2012 ; Park and Oh, 2014 ; Yao et al, 2015b ; Li et al, 2017b ; Park et al, 2017 ; Chaudhary et al, 2019 ).…”

Section: Botanical Description and Traditional Usagesmentioning

confidence: 99%

Juglans mandshurica Maxim.: A Review of Its Traditional Usages, Phytochemical Constituents, and Pharmacological Properties

Luan

Wang²,

Yang

et al. 2021

Front. Pharmacol.

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Juglans mandshurica Maxim., also known as “Manchurian walnut” (Chinese) and “Onigurumi” (Japanese), is a medicinal plant widely distributed in Western and Central Asia, especially in China. It has been traditionally used to treat cancer, gastric ulcers, diarrhea, dysentery, dermatosis, uterine prolapse, and leukopenia. To date, more than 400 constituents including quinones (e.g. naphthoquinones, anthraquinones, naphthalenones, tetralones), phenolics, flavonoids, triterpenoids, coumarins, lignans, phenylpropanoids, diarylheptanoids, and steroids, were isolated and structurally identified from different plant parts of J. mandshurica. Among them, quinones, phenolics, triterpenoids, and diarylheptanoids, as the major bioactive substances, have been extensively studied and displayed significant bioactivity. Previous studies have demonstrated that J. mandshurica and a few of its active components exhibit a wide range of pharmacologically important properties, such as antitumor, immunomodulatory, anti-inflammatory, neuroprotective, anti-diabetic, antiviral, antimicrobial, and anti-melanogenesis activities. However, many investigations on biological activities were mainly based on crude extracts of this plant, and the major bioactive ingredients responsible for these bioactivities have not been well identified. Further in vitro and in vivo studies on the mechanisms of action of the pure bioactive compounds, and more elaborate toxicity studies as well as clinical studies are needed to ensure safety and effectiveness of the plant for human use. Taken together, the present review will provide some specific useful suggestions guide to further investigations and applications of this plant in the preparation of medicines and functional foods.

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“…Fresh Juglans mandshurica fruits have been used in folk medicine for the treatment of cancer, dermatosis, gastritis, and cardiovascular diseases, and as an anodyne to relieve aches in China (Chao et al, ; Liu, Li, Kazuo, & Tamotsu, ; Xu et al, ). Compared with the phytochemical investigations performed on Juglans mandshurica root (Li et al, , ) and leaves (Park, Jang, & Oh, ; Yao et al, ), very few studies have been conducted on the bioactive properties of WHPs obtained from the fruit protein of Juglans mandshurica Maxim. Their antidiabetic activity has not been reported, although the antidiabetic activities of peptides from other kinds of proteins have been demonstrated previously (Ren et al, ; Yuan, Gu, & Tang, ); thus, it would be very meaningful to investigate the antidiabetic potential of the WHPs.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the antidiabetic activity of hydrolyzed peptides derived fromJuglans mandshuricaMaxim. fruits in insulin-resistant HepG2 cells and type 2 diabetic mice

et al. 2018

J Food Biochem

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Bioactive peptides derived from plant proteins are promising sources for the development safe hypoglycemics. The present study was designed to investigate the antidiabetic activity of walnut hydrolyzed peptides (WHPs) obtained from the fruit proteins of Juglans mandshurica Maxim. In vitro results showed that WHPs with medium molecular weights (3-10 kDa) exhibited the highest a-glucosidase inhibitory rate (61.73%) and significantly increased extracellular glucose consumption in insulin-resistant HepG2 cells. In mice with streptozotocin-induced type 2 diabetes, WHPs with medium molecular weights reduced fasting blood glucose levels by 64.82% and increased insulin secretion by 23.71% and liver glucokinase and glycogen levels by 69.54 and 76.19%, respectively. Furthermore, an analysis of serum lipid profiles showed that WHPs significantly decreased serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels. Our results indicate the antidiabetic potential of WHPs and provide evidence to support the application of WHPs in the treatment of diabetes. Practical applicationsJuglans mandshurica Maxim., commonly known as the Manchurian walnut, is a member of the Juglandaceae plant family. Its fruit is extensively consumed in northeast China and is used in the production of dairy and bakery products, candy, and cooking oil owing to its high protein content (about 30%), abundance of essential amino acids, and easy digestibility. Hence, there has been an immense increase, up to a million hectare, in the area under Manchurian walnut cultivation. The results of the present study indicated that WHPs showed significant antidiabetic activity by improving a-glucosidase activity, glucose metabolism, insulin secretion, and liver glucokinase and glycogen levels as well as by decreasing the fasting blood glucose level. These findings have identified a green source of novel antidiabetic peptides that can either be used as a functional food ingredient in the management of hyperglycemia or developed as a drug for the treatment of type 2 diabetes.

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Three new compounds from the roots of Juglans mandshurica Maxim.

Cited by 13 publications

References 20 publications

Identification of Polar Constituents in the Decoction of Juglans mandshurica and in the Medicated Egg Prepared with the Decoction by HPLC-Q-TOF MS2

Identification of Polar Constituents in the Decoction of Juglans mandshurica and in the Medicated Egg Prepared with the Decoction by HPLC-Q-TOF MS2

Juglans mandshurica Maxim.: A Review of Its Traditional Usages, Phytochemical Constituents, and Pharmacological Properties

Evaluation of the antidiabetic activity of hydrolyzed peptides derived fromJuglans mandshuricaMaxim. fruits in insulin-resistant HepG2 cells and type 2 diabetic mice

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