Three New Cholinesterase Inhibitory Cassioates from Cassia Fistula

Aftab, Zahida; Bushra,; Khan, Hizbullah; Khan, Dil Faraz; Khan, Asifullah; Ullah, Hamid; Shahnaz,; Shafiullah, Khan

doi:10.1007/s11094-020-02124-y

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…Other miscellenous compounds ( Table S4 ) have equally shown interesting acetylcho-linesterase and butyrylcholinesterase inhibitory activities [ 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 ].…”

Section: Discussionmentioning

confidence: 99%

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

et al. 2021

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Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient’s daily activities such as memory impairment. The most important challenge concerning AD is the development of new drugs for long-term treatment or prevention, with lesser side effects and greater efficiency as cholinesterases inhibitors and the ability to remove amyloid-beta(Aβ) deposits and other related AD neuropathologies. Natural sources provide promising alternatives to synthetic cholinesterase inhibitors and many have been reported for alkaloids while neglecting other classes with potential cholinesterase inhibition. This review summarizes information about the therapeutic potential of small natural molecules from medicinal herbs, belonging to terpenoids, coumarins, and phenolic compounds, and others, which have gained special attention due to their specific modes of action and their advantages of low toxicity and high efficiency in the treatment of AD. Some show superior drug-like features in comparison to synthetic cholinesterase inhibitors. We expect that the listed phytoconstituents in this review will serve as promising tools and chemical scaffolds for the discovery of new potent therapeutic leads for the amelioration and treatment of Alzheimer’s disease.

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Section: Discussionmentioning

confidence: 99%

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

et al. 2021

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“…Overall, phytochemical studies of the Cassia genus have shown that it is commonly used in traditional medicine as a purgative, diuretic, antiseptic, and an antioxidant to treat ulcers, jaundice, and various skin diseases including leprosy. 1,2 Previous phytochemical studies of C. fistula extracts revealed the presence of coumarins, alkaloids, glycosides anthraquinones, and phenolic constituents. 3 Additionally, the ripe fruit pulp contains a significant amount of anthraquinones in the form of rhein as well as soluble sugars, volatile oils, and resins.…”

Section: Introductionmentioning

confidence: 99%

“…4 Purified rhamnetin 3-O-gentiobioside (from roots), sennosides A & B (from leaves), fistulin and kaempferol (from flowers), isoflavone biochanin A (from fruits), and three new compounds designated cassioates D, E, and F (from the whole plant) have been previously isolated from C. fistula . 1,5,6 The aforementioned secondary metabolites are well-recognized as exhibiting various biological activities. For example, in vitro antioxidant activity of hydroalcoholic seed extracts of Cassia fistula has been reported.…”

Section: Introductionmentioning

confidence: 99%

Chemical characterization ofCassia fistulapolysaccharide (CFP) and its potential application as a prebiotic in synbiotic preparation

et al. 2021

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“…In general, the Cassia genus is a promising source of anti-cholinesterase compounds. Few potential AChE inhibitors have been identified from Cassia species, such as anthraquinones (physcion, emodin, and alaternin), terpenoids (cassioates E and F), and 3-methoxyquercetin [ 17 , 83 , 84 , 85 ]. We postulate that the diverse secondary metabolites in the anti-AChE activity of C. timoriensis extracts, as seen in Table 1 , may lead to the identification of potential compounds that inhibit AChE activity.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of Cassia timoriensis DC. Flowers

et al. 2021

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Despite being widely used traditionally as a general tonic, especially in South East Asia, scientific research on Cassia timoriensis, remains scarce. In this study, the aim was to evaluate the in vitro activities for acetylcholinesterase (AChE) inhibitory potential, radical scavenging ability, and the anti-inflammatory properties of different extracts of C. timoriensis flowers using Ellman’s assay, a DPPH assay, and an albumin denaturation assay, respectively. With the exception of the acetylcholinesterase activity, to the best of our knowledge, these activities were reported for the first time for C. timoriensis flowers. The phytochemical analysis confirmed the existence of tannins, flavonoids, saponins, terpenoids, and steroids in the C. timoriensis flower extracts. The ethyl acetate extract possessed the highest phenolic and flavonoid contents (527.43 ± 5.83 mg GAE/g DW and 851.83 ± 10.08 mg QE/g DW, respectively) as compared to the other extracts. In addition, the ethyl acetate and methanol extracts exhibited the highest antioxidant (IC50 20.12 ± 0.12 and 34.48 ± 0.07 µg/mL, respectively), anti-inflammatory (92.50 ± 1.38 and 92.22 ± 1.09, respectively), and anti-AChE (IC50 6.91 ± 0.38 and 6.40 ± 0.27 µg/mL, respectively) activities. These results suggest that ethyl acetate and methanol extracts may contain bioactive compounds that can control neurodegenerative disorders, including Alzheimer’s disease, through high antioxidant, anti-inflammatory, and anti-AChE activities.

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Three New Cholinesterase Inhibitory Cassioates from Cassia Fistula

Cited by 4 publications

References 8 publications

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

Chemical characterization ofCassia fistulapolysaccharide (CFP) and its potential application as a prebiotic in synbiotic preparation

Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of Cassia timoriensis DC. Flowers

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