Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet

Three-generation experiment showed female C57BL/6J mice drink drainage canal water containing low level of TCDD-like activity causing high pup mortality

“…Reproductive organs and embryos are more sensitive to the hazardous effects of these chemicals (Kransler et al, 2007). A typical three-generation study in the diet showed that female reproductive performance in rats was reduced with receiving 10 ng/kg/ day of TCDD (Murray et al, 1979). We previously found that a 50 ng/kg/day exposure to TCDD for 8 days inhibited the decidual cell response and the number of implanted embryos (Li et al, 2006).…”

Proteome Analysis of the Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Murine Testicular Leydig and Sertoli Cells.

“…Its effect on the male reproductive system has been widely discussed, and many such effects are reported in rodents exposed to TCDD: reduced testis and sex accessory gland weight, impaired spermatogenesis, decreased ejaculation, and decreased plasma androgen concentrations. [7][8][9] Since maternal TCDD exposure in rodents could similarly affect the perinatal androgenic status in male offspring in utero and during lactation, 8,[10][11][12][13] the effects on future generations are worrisome. The probability of developing any one of these disorders varies greatly with dose, length of exposure, and, most importantly, the species exposed, 1) making it difficult to determine the TCDD threshold for toxicity.…”

Chlorinated dioxins and dibenzofurans in the environment--a hazard to public health?

“…While sufficient evidence does not exist to link 2,3,7,8-TCDD to human reproductive or developmental toxicity (see, eg, references 28 and 34), it has been shown to be a reproductive or developmental toxicant in a wide variety of animal species (35,36). Animal stud ies have also shown that extended periods of exposure are not necessary for developmental toxicity to result.…”