Three doses of vitamin D, bone mineral density, and geometry in older women during modest weight control in a 1-year randomized controlled trial

Pop, L. Claudia; Sukumar, Deeptha; Schneider, Stephen H.; Schlussel, Yvette; Stahl, Theodore; Gordon, Christopher L.; Wang, X.; Papathomas, Thomas V.; Shapses, Sue A.

doi:10.1007/s00198-016-3735-z

Cited by 33 publications

(40 citation statements)

References 52 publications

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“…Although the primary outcome of the trial was to assess the influence of a Mg diet strategy on vitamin D status in postmenopausal women, the sample size in each group would allow us to preliminarily obtain significant results, although the results should be carefully considered. Clinical trials of the same nature and a similar sample size have shown a positive effect of different interventions on some parameters status in postmenopausal women [54][55][56]. Likewise, the sample size limitation did not allow us to make a more complex statistical approach since we did not have enough power to perform multivariate analyses and to be able to adjust our model based on possible confounding variables such as previously described age or BMI.…”

Section: Discussionmentioning

confidence: 98%

Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

et al. 2020

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Menopause is a stage of hormonal imbalance in women which, in addition to other physiopathological consequences, poses a risk of deficiency of key micronutrients such as magnesium and vitamin D. A study was made of the influence of a magnesium intervention upon vitamin D status in a postmenopausal population from the province of Granada (Spain). Fifty-two healthy postmenopausal women between 44–76 years of age were included. Two randomized groups—placebo and magnesium (500 mg/day)—were treated during eight weeks. Nutrient intake was assessed using questionnaires based on 72-h recall. Vitamin D was analyzed by liquid chromatography—tandem mass spectrometry. Baseline vitamin D proved deficient in over 80% of the subjects. The administration of magnesium resulted in significantly increased vitamin D levels in the intervention group versus the controls (p < 0.05). Magnesium supplementation improved vitamin D status in the studied postmenopausal women.

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Section: Discussionmentioning

confidence: 98%

Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

et al. 2020

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“…One-year, randomized, double-blind controlled study examined the influence of vitamin D in healthy obese older women on the density and quality of bone in fifty eight elderly women surveyed. The decline in the thickness of the cortical width of the tibia was prevented by the treatment of higher doses of vitamin D, but there were no other significant changes caused by the treatment over a period of one year [12].…”

Section: Nutrition and Health Of Elderly Peoplementioning

confidence: 88%

The impact of nutrition on the health of the elderly

Despotović¹,

Ilić²,

Stanojević³

et al. 2016

Hrana i ishrana

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Introduction: Elders have higher health risks due to changes connected with general abilities and everyday functioning as a result of biological ageing. Researchers have shown that 4 out of 5 elderly people suffer from some kind of chronic illness, and the needs of this population are mainly connected to the supply of adequate medical and social support. Adequate nutrition is an important protection factor, characteristic for the general health of the elderly population, in cases such as chronic cardiovascular diseases, cognitive problems, etc. Both obesity and malnutrition are important health problems amongst elders. The aim: The aim of this article is to analyze the importance of effects related to the nutritional needs amongst the elderly and to provide guidance for further researches. Materials and methods: The article is written based on recent scientific literature review, and uses descriptive methods and scientific documents analysis. Nutrition and health of elderly: Persons above the age of 65, suffer higher risk of health problems due to nutritional factors associated with illnesses commonly related to ageing, such as co morbidity in correlation with psychological health. Luger and others found connections between malnutrition, social participation and Qol amongst elders. Despite that, they couldn't prove if malnutrition is cause or consequence. New studies have shown nutrition has important influence on skeletomuscular pain, liver diseases, fractures, cardiovascular diseases, diabetes, cognitive problems and colorectal cancer. Conclusion: Based on present knowledge, we can conclude that adequate nutritional supply can work as an important protective factor to benefit the general health status of the elders. It is necessary to develop national health strategies, educate population, while national Social and Health policies needs to recognize the nutritional needs of elderly people to ensure they are able to get the right amount of healthy foods required for securing their well being. New research should focus on different dietary styles and gender differences in health status connected to dietary intake.

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“…Consistent with a meta‐analysis of RCTs that showed a significantly inferior effect of higher‐dose vitamin D supplementation on aBMD in the lumbar spine compared with lower‐dose vitamin D supplementation, Mendelian randomization analyses have found a possible inverse relation of vitamin D status with skeletal health . Consequently, the possibility of a causal positive association between serum 25(OH)D levels and aBMD would be almost ruled out by these two key analyses to assess causality, though the indirect effects of high‐dose vitamin D supplements in RCTs could be detected in the hip or tibia . Accordingly, the positive linear correlation between serum 25(OH)D levels at 12 months and change in aBMD in the lumbar spine can be interpreted as a result of the involvement of individual life and health status including physical activity outdoors because the wide variability in serum 25(OH)D levels after supplementation with vitamin D suggests that serum 25(OH)D levels at 12 months resulted not only from vitamin D supplements, but also from other factors such as vitamin D synthesis in the skin following sunlight exposure.…”

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confidence: 88%

Towards a Consensus on Vitamin D Supplementation and Bone Health

Sugiyama

2019

Journal of Bone and Mineral Research

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In a 3-year randomized controlled trial (RCT) that investigated the effects of daily high-dose vitamin D supplements (mean 3490 IU/day) on areal bone mineral density (aBMD) in the hip, lumbar spine, radius, and total body among elderly healthy black American women with a baseline mean of 55 nmol/L of serum 25-hydroxyvitamin D (25[OH]D), Aloia and colleagues (1) demonstrated that higher levels of serum 25(OH)D targeted above 75 nmol/L (mean 108, 114, and 117 nmol/L at 12, 24, and 36 months, respectively) in the active group had no clinically meaningful impact on aBMD in any region analyzed compared with the placebo group (mean 48, 49, and 51 nmol/L at 12, 24, and 36 months, respectively). Notably, this marked evidence fully agrees with findings from other RCTs of high-dose vitamin D, for instance, among older overweight adults with weekly supplementation (2) and healthy children and pregnant women with daily supplementation. (3,4) In contrast, many observational studies have reported a significant positive association between serum 25(OH)D levels and aBMD. The discrepancy is a timely and important issue that should be resolved to achieve a consensus on vitamin D supplements and skeletal health.In a recent 1-year RCT among aged white and black women with serum 25(OH)D below 50 nmol/L recruited from the general population, there were no effects of increasing daily vitamin D doses ranging from 400 to 4800 IU/day on aBMD in the hip, lumbar spine, and total body, whereas a significant positive linear correlation was observed between serum 25(OH)D levels at 12 months and change in aBMD in the lumbar spine. (5) Consistent with a meta-analysis of RCTs that showed a significantly inferior effect of higher-dose vitamin D supplementation on aBMD in the lumbar spine compared with lower-dose vitamin D supplementation, (6) Mendelian randomization analyses have found a possible inverse relation of vitamin D status with skeletal health. (7) Consequently, the possibility of a causal positive association between serum 25(OH)D levels and aBMD would be almost ruled out by these two key analyses to assess causality, (6,7) though the indirect effects (8) of high-dose vitamin D supplements in RCTs could be detected in the hip or tibia. (9-11) Accordingly, the positive linear correlation between serum 25(OH)D levels at 12 months and change in aBMD in the lumbar spine (5) can be interpreted as a result of the involvement of individual life and health status including physical activity outdoors (12) because the wide variability in serum 25(OH)D levels after supplementation with vitamin D (5) suggests that serum 25(OH)D levels at 12 months resulted not only from vitamin D supplements, but also from other factors such as vitamin D synthesis in the skin following sunlight exposure.In conclusion, I would like to emphasize that understanding the noncausal positive association between serum 25(OH)D levels and skeletal health in observational studies is essential to building a consensus that the recommended dietary allowance for vitamin D by the ...

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Three doses of vitamin D, bone mineral density, and geometry in older women during modest weight control in a 1-year randomized controlled trial

Cited by 33 publications

References 52 publications

Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

The impact of nutrition on the health of the elderly

Towards a Consensus on Vitamin D Supplementation and Bone Health

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