Three‐dimensionally printed polyetherketoneketone scaffolds with mesenchymal stem cells for the reconstruction of critical‐sized mandibular defects

Roskies, Michael; Fang, Dongdong; Abdallah, Mohamed‐Nur; Charbonneau, André M.; Cohen, Navi; Jordan, Jack; Hier, Michael P.; Mlynarek, Alex; Tran, Simon D.

doi:10.1002/lary.26781

Cited by 43 publications

(65 citation statements)

References 23 publications

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“…Lopez et al treated mandibular defects in a rabbit model with a 3D‐printed bioceramic scaffold that exhibited bony ingrowth 59 . 3D‐printing has also been able to generate microstructures that simulate the stiffness of the mandibular condyle and even have demonstrated compressive resistances 15 times greater than bone in a rabbit model 54,60 …”

Section: Discussionmentioning

confidence: 99%

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Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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While tissue engineering holds significant potential to address current limitations in reconstructive surgery of the head and neck, few constructs have made their way into routine clinical use. In this review, we aim to appraise the state of head and neck tissue engineering over the past five years, with a specific focus on otologic, nasal, craniofacial bone, and laryngotracheal applications. A comprehensive scoping search of the PubMed database was performed and over 2000 article hits were returned with 290 articles included in the final review. These publications have addressed the hallmark characteristics of tissue engineering (cellular source, scaffold, and growth signaling) for head and neck anatomical sites. While there have been promising reports of effective tissue engineered interventions in small groups of human patients, the majority of research remains constrained to in vitro and in vivo studies aimed at furthering the understanding of the biological processes involved in tissue engineering. Further, differences in functional and cosmetic properties of the ear, nose, airway, and craniofacial bone affect the emphasis of investigation at each site. While otolaryngologists currently play a role in tissue engineering translational research, continued multidisciplinary efforts will likely be required to push the state of translation towards tissue‐engineered constructs available for routine clinical use. Level of Evidence NA.

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Section: Discussionmentioning

confidence: 99%

“…Heatmap representing the proportion of publications by year that utilized specific translational research methodologies from construct characterization to human trial to investigate craniofacial tissue engineering 49‐72,74‐77,79,81‐84,145‐197 …”

Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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“…And 3D printing technology can provide a reasonable structure for adipose stem cells in tissue engineering. So it can be used for rebuilding the nasal type (Yi et al, 2019), auricle regeneration (Lee et al, 2014; Visscher et al, 2016), rebuilding the maxillofacial cartilage (Morrison et al, 2018), filling defect of bone (Roskies et al, 2017; Wang et al, 2016; Wenz, Borchers, Tovar, & Kluger, 2017), reconstruction of blood vessels (Zhao et al, 2016), and even printing organs (Kapur et al, 2012). Noor et al (2019) reprogrammed the omental tissue cells into pluripotent stem cells and then differentiated them into cardiomyocytes and endothelial cells.…”

Section: D Printing and Organs Printingmentioning

confidence: 99%

Three‐dimensional printing: The potential technology widely used in medical fields

Fan

Zhu

2020

J Biomedical Materials Res

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Three‐dimensional (3D) printing technology is one of the hottest research fields nowadays, which has influenced the treatment methods in the medical industry. In order to explore the progress of 3D printing technology in medical applications, the authors conducted English retrieval with the keywords “three‐dimensionalprinting,” “bioprinting,” and “3D printing” in PubMed, and extracted information related to this exploration. This review firstly introduces the 3D printing materials, types of technology, and printing procedures in medical fields, then elaborates the current applications of 3D printing in medical devices, in vitro anatomical models, organ printing, implants, tissue engineering scaffolds, and the leap from 3D medical printing to four‐dimensional (4D) medical printing, finally put forward the shortage of the medical 3D/4D printing and possible solutions of them.

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“…27 ADSCs have aroused more attention in tissue engineering due to its easy access to large amounts and relatively noninvasive acquisition method. 28,29 Scaffolds seeded with rADSCs significantly promoted bone regeneration after implantation in rat critical-sized calvarial defects when compared with pure scaffolds. 30 In this study, we fabricated PLGA/PCL scaffolds loaded with BMP-2 through coaxial electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Thermally induced self-agglomeration 3D scaffolds with BMP-2-loaded core–shell fibers for enhanced osteogenic differentiation of rat adipose-derived stem cells

Chen

Zhou

et al. 2018

IJN

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IntroductionScaffold structure plays a vital role in cell behaviors. Compared with two-dimensional structure, 3D scaffolds can mimic natural extracellular matrix (ECM) and promote cell–cell and cell–matrix interactions. The combination of osteoconductive scaffolds and osteoinductive growth factors is considered to have synergistic effects on bone regeneration.Materials and methodsIn this study, core–shell poly(lactide-co-glycolide) (PLGA)/polycaprolactone (PCL)–BMP-2 (PP–B) fibrous scaffolds were prepared through coaxial electrospinning. Next, we fabricated 3D scaffolds based on PP–B fibers with thermally induced self-agglomeration (TISA) method and compared with conventional PLGA/PCL scaffolds in terms of scaffold morphology and BMP-2 release behaviors. Then, rat adipose-derived stem cells (rADSCs) were seeded on the scaffolds, and the effects on cell proliferation, cell morphology, and osteogenic differentiation of rADSCs were detected.ResultsThe results demonstrated that 3D scaffold incorporated with BMP-2 significantly increased proliferation and osteogenic differentiation of rADSCs, followed by PP–B group.ConclusionOur findings indicate that scaffolds with 3D structure and osteoinductive growth factors have great potential in bone tissue engineering.

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Three‐dimensionally printed polyetherketoneketone scaffolds with mesenchymal stem cells for the reconstruction of critical‐sized mandibular defects

Abstract: NA. Laryngoscope, 127:E392-E398, 2017.

Cited by 43 publications

References 23 publications

Tissue engineering applications in otolaryngology—The state of translation

Tissue engineering applications in otolaryngology—The state of translation

Three‐dimensional printing: The potential technology widely used in medical fields

Thermally induced self-agglomeration 3D scaffolds with BMP-2-loaded core–shell fibers for enhanced osteogenic differentiation of rat adipose-derived stem cells

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Three‐dimensionally printed polyetherketoneketone scaffolds with mesenchymal stem cells for the reconstruction of critical‐sized mandibular defects

Abstract: NA. Laryngoscope, 127:E392-E398, 2017.

Cited by 43 publications

References 23 publications

Tissue engineering applications in otolaryngology—The state of translation

Tissue engineering applications in otolaryngology—The state of translation

Three‐dimensional printing: The potential technology widely used in medical fields

Thermally induced self-agglomeration 3D scaffolds with BMP-2-loaded core&ndash;shell fibers for enhanced osteogenic differentiation of rat adipose-derived stem cells

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Thermally induced self-agglomeration 3D scaffolds with BMP-2-loaded core–shell fibers for enhanced osteogenic differentiation of rat adipose-derived stem cells