Three dimensionally printed mesoporous bioactive glass and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) composite scaffolds for bone regeneration

Zhao, Shichang; Zhu, Menglin; Zhang, Jianhua; Zhang, Yadong; Liu, Zhongtang; Zhu, Yufang; Zhang, Changqing

doi:10.1039/c4tb00838c

Cited by 95 publications

(59 citation statements)

References 49 publications

(54 reference statements)

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“…Zhao et al [109] developed scaffolds with high osteogenic capability combining mesoporous bioactive glass (MBG) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) via 3D printing. The biocomposite scaffolds had uniform interconnected macropores and high porosity, and their compressive strength was approximately 200 times higher than that of polyurethane foam templated MBG scaffolds.…”

Section: Stereolithography (Sla)mentioning

confidence: 99%

Bioactive Glass-Biopolymer Composites for Applications in Tissue Engineering

Ding¹,

Souza²,

Li³

et al. 2016

Handbook of Bioceramics and Biocomposites

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Section: Stereolithography (Sla)mentioning

confidence: 99%

Bioactive Glass-Biopolymer Composites for Applications in Tissue Engineering

Ding¹,

Souza²,

Li³

et al. 2016

Handbook of Bioceramics and Biocomposites

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“…Zhao et al [108] developed scaffolds with high osteogenic capability combining mesoporous bioactive glass (MBG) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) via 3D printing. The biocomposite scaffolds had uniform interconnected macropores and high porosity, and their compressive strength was approximately 200 times higher than that of polyurethane foam templated MBG scaffolds.…”

Section: D Printing (3dp)mentioning

confidence: 99%

Bioactive Glass-Biopolymer Composites

Ding¹,

Souza²,

Li³

et al. 2015

Handbook of Bioceramics and Biocomposites

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Tissue engineering (TE) is a biomedical field in continuous expansion. However, there are still many challenges, and the further development of TE approaches requires interdisciplinary interaction and collaboration among various research areas with a notable contribution expected from biomaterials science. In the last couple of decades, significant advances in the development of biomaterial-based scaffolds for hard and soft tissue regeneration have been accomplished, including the manufacture of biocomposites that combine natural or synthetic polymers with bioactive glasses or glass-ceramics. These novel biomaterials present the possibility of tailoring a variety of parameters and properties such as degradation kinetics, mechanical properties, and chemical composition according to the aimed application. This chapter presents a concise update of the field of biopolymer-bioactive glass composite scaffold development for TE covering several popular processing techniques for biocomposite fabrication, namely, microsphere processing, solvent casting-particulate leaching method, electrospinning, freezedrying, and rapid prototyping techniques, which lead to scaffolds exhibiting a variety of 3D morphologies and different pore structures.

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“…10% was noted after 45 days for the PHB/BG (80/20 w/w) composite in comparison to 21% for PLGA/BG (80/20 w/w) composites . PHBHHx/mesoporous bioactive glass (75–89 wt % BG) composites degraded at an acceptable rate, with the composites losing 13–18% of their initial weight over 30 days . Interestingly, the presence of only 10 wt % BG in the composites helped to stabilise pH in the range of 7.4‐7.6 while pH dropped to 5.8 for pure PHBV during the same time frame .…”

Section: Bone Tementioning

confidence: 99%

“…PHBV/BG composites (porosity= 78%, contact angle= 52°) showed better bioactivity than PHBV/HA since they induced the formation of apatite after soaking in SBF for only 3 days compared to 7 days for PHBV/HA . PHBHHx/mesoporous bioactive glass (MBG) (75–89 wt % BG) scaffolds supported hBMSCs' adhesion and proliferation, stimulated ALP activity, RUNX2, OCN and BMP‐2 mRNA osteogenic gene expressions . Significantly more bone formation was noted on implantation of the PHBHHx/75% mesoporous BG scaffolds in rat models indicative of a more rapid rate of bone remodeling (Figure ).…”

Section: Bone Tementioning

confidence: 99%

Third generation poly(hydroxyacid) composite scaffolds for tissue engineering

et al. 2016

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Bone tissue engineering based on scaffolds is quite a complex process as a whole gamut of criteria needs to be satisfied to promote cellular attachment, proliferation and differentiation: biocompatibility, right surface properties, adequate mechanical performance, controlled bioresorbability, osteoconductivity, angiogenic cues, and vascularization. Third generation scaffolds are more of composite types to maximize biological-mechanical-chemical properties. In the present review, our focus is on the performance of micro-organism-derived polyhydroxyalkanoates (PHAs)-polyhydroxybutyrate (PHB) and polyhydroxybutyrate-co-valerate (PHBV)-composite scaffolds with ceramics and natural polymers for tissue engineering applications with emphasis on bone tissue. We particularly emphasize on how material properties of the composites affect scaffold performance. PHA-based composites have demonstrated their biocompatibility with a range of tissues and their capacity to induce osteogenesis due to their piezoelectric properties. Electrospun PHB/PHBV fiber mesh in combination with human adipose tissue-derived stem cells (hASCs) were shown to improve vascularization in engineered bone tissues. For nerve and skin tissue engineering applications, natural polymers such as collagen and chitosan remain the gold standard but there is scope for development of scaffolds combining PHAs with other natural polymers which can address some of the limitations such as brittleness, lack of bioactivity and slow degradation rate presented by the latter. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1667-1684, 2017.

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Three dimensionally printed mesoporous bioactive glass and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) composite scaffolds for bone regeneration

Cited by 95 publications

References 49 publications

Bioactive Glass-Biopolymer Composites for Applications in Tissue Engineering

Bioactive Glass-Biopolymer Composites for Applications in Tissue Engineering

Bioactive Glass-Biopolymer Composites

Third generation poly(hydroxyacid) composite scaffolds for tissue engineering

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