Three‐dimensional whole‐heart T<sub>2</sub> mapping at 3T

Ding, Haiyan; Fernandez-de-Manuel, Laura; Schär, Michael; Schuleri, Karl H.; Halperin, Henry R.; He, Le; Zviman, Muz; Beinart, Roy; Herzka, Daniel A.

doi:10.1002/mrm.25458

Cited by 57 publications

(106 citation statements)

References 58 publications

(83 reference statements)

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“…Three-dimensional (3D) mapping may allow for more complete coverage of the heart and a better characterization of complex regional distribution patterns of disease processes [53, 54, 187]. …”

Section: Future Directionsmentioning

confidence: 99%

Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)

Messroghli

Moon

Ferreira

et al. 2016

Journal of Cardiovascular Magnetic Resonance

1,228

1,282

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Parametric mapping techniques provide a non-invasive tool for quantifying tissue alterations in myocardial disease in those eligible for cardiovascular magnetic resonance (CMR). Parametric mapping with CMR now permits the routine spatial visualization and quantification of changes in myocardial composition based on changes in T1, T2, and T2*(star) relaxation times and extracellular volume (ECV). These changes include specific disease pathways related to mainly intracellular disturbances of the cardiomyocyte (e.g., iron overload, or glycosphingolipid accumulation in Anderson-Fabry disease); extracellular disturbances in the myocardial interstitium (e.g., myocardial fibrosis or cardiac amyloidosis from accumulation of collagen or amyloid proteins, respectively); or both (myocardial edema with increased intracellular and/or extracellular water). Parametric mapping promises improvements in patient care through advances in quantitative diagnostics, inter- and intra-patient comparability, and relatedly improvements in treatment. There is a multitude of technical approaches and potential applications. This document provides a summary of the existing evidence for the clinical value of parametric mapping in the heart as of mid 2017, and gives recommendations for practical use in different clinical scenarios for scientists, clinicians, and CMR manufacturers.

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Section: Future Directionsmentioning

confidence: 99%

Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)

Messroghli

Moon

Ferreira

et al. 2016

Journal of Cardiovascular Magnetic Resonance

1,228

1,282

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“…complete coverage of the heart and better characterization of complex regional distribution of disease processes. [12][13][14][15][16][17][18][19][20][21][22] This has been preliminarily validated in several patient studies. 23,24 However, the relatively long scan time that results from 3D imaging in the presence of cardiac and respiratory motion limits the number of differentially weighted volumes that can be acquired, 12 the measurable range of the relaxation times, 13 and the in-plane resolution.…”

Section: Magnetic Resonance In Medicinementioning

confidence: 94%

A three‐dimensional free‐breathing sequence for simultaneous myocardial T₁ and T₂ mapping

Guo

Chen

Herzka

et al. 2018

Magnetic Resonance in Med

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Purpose: The aim of this study was to develop, test and validate a 3D free‐breathing technique for simultaneous measurement of native myocardial T1 and T2. Methods: The proposed 3D technique acquires five fat‐suppressed electrocardiogram‐triggered respiratory navigator‐gated spoiled gradient echo volumes in an interleaved manner. Four volumes are prepared using a combination of nonselective saturation and T2 preparation. One volume is acquired with fully recovered longitudinal magnetization for accuracy during parametric fitting. Performance of the technique was validated through numerical simulations, phantom experiments and in vivo experiments in 15 healthy human subjects. Results: Simulations and phantom experiments show that the measured T1 and T2 are largely insensitive to heart rate. In vivo whole‐heart maps with a voxel size of 1.5 × 1.5 × 16 mm3 were acquired without parallel imaging within ~ 8 min including respiratory gating efficiency. The in vivo parametric maps were homogeneous (coefficients of variation of left ventricle myocardium were 6.0% ± 0.8% and 10.2% ± 3.4% for T1 and T2 maps, respectively), with an average T1 value of 1470 ± 59.2 ms and T2 value of 41.6 ± 1.8 ms Conclusions: The proposed 3D technique allows for measurement of whole‐heart T1 and T2 with preserved accuracy and precision in a single scan.

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“…In van Heeswijk et al (11), a T 2 value range of 35-45 ms was reported across segments. In Ding et al (12), the standard deviation of myocardial T 2 measurements was 3.5-5 ms across the entire myocardium. We FIG.…”

Section: Discussionmentioning

confidence: 94%

Free-breathing slice-interleaved myocardial T₂mapping with slice-selective T₂magnetization preparation

et al. 2015

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Purpose To develop and evaluate a free-breathing slice-interleaved T2 mapping sequence by proposing a new slice-selective T2 magnetization preparation (T2prep) sequence that allows interleaved data acquisition for different slices in subsequent heart beats. Methods We developed a slice-selective T2prep for myocardial T2 mapping by adding slice-selective gradients to conventional single-slice T2prep sequence. In this sequence, 5 slices are acquired during 5 consecutive heartbeats, each using a slice selective T2prep. The scheme is repeated four times using different T2prep echo times. We compared the performance of the proposed slice-interleaved T2 mapping sequence and the conventional single-slice T2 mapping sequence in term of accuracy, precision and reproducibility using phantom experiments and in-vivo imaging in 10 healthy subjects. We also evaluated the feasibility of the proposed sequence in 28 patients with cardiovascular disease and the quality of the maps was subjectively scored. Furthermore, we investigated the impact of through-plane motion by comparing T2 measurements acquired during end-systole vs. mid-diastole. Results T2 measurements using slice-interleaved T2 mapping sequence were correlated with spin-echo (r2 = 0.88) and single-slice T2 mapping sequence (r2 = 0.98). The mean myocardial T2 values were correlated between slice-interleaved (48 ms) and single-slice (51 ms) T2 mapping sequences. Subjective scores of T2 map quality were good to excellent in 81% of the maps in patients. There was no difference in T2 measurements between end-systole vs. mid-diastole. Conclusions The proposed free-breathing slice-interleaved T2 mapping sequence allows T2 measurements of 5 left ventricular slices in 20 heartbeats with similar reproducibility and precision as the single-slice T2 mapping sequence but with 4-fold reduction in acquisition time.

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Three‐dimensional whole‐heart T₂ mapping at 3T

Abstract: Free-breathing accurate 3D T2 mapping is feasible and may be applicable in myocardial assessment in lieu of current clinical black blood, T2 -weighted techniques.

Cited by 57 publications

References 58 publications

Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)

Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)

A three‐dimensional free‐breathing sequence for simultaneous myocardial T₁ and T₂ mapping

Free-breathing slice-interleaved myocardial T₂mapping with slice-selective T₂magnetization preparation

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Three‐dimensional whole‐heart T2 mapping at 3T

Abstract: Free-breathing accurate 3D T2 mapping is feasible and may be applicable in myocardial assessment in lieu of current clinical black blood, T2 -weighted techniques.

Cited by 57 publications

References 58 publications

Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)

Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)

A three‐dimensional free‐breathing sequence for simultaneous myocardial T1 and T2 mapping

Free-breathing slice-interleaved myocardial T2mapping with slice-selective T2magnetization preparation

Contact Info

Product

Resources

About

Three‐dimensional whole‐heart T₂ mapping at 3T

A three‐dimensional free‐breathing sequence for simultaneous myocardial T₁ and T₂ mapping

Free-breathing slice-interleaved myocardial T₂mapping with slice-selective T₂magnetization preparation