Three-dimensional ultrasound as a predictor of pregnancy in patients undergoing ART

Yaman, Cemil; Mayer, RB

doi:10.5152/jtgga.2012.15

Cited by 17 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yaman et al. reported that 3-D energy Doppler offers a unique tool to reflect the vascular structure of the whole endometrium and the supply of blood flow, which could be used as a predictor of pregnancy in patients who accepted assisted reproductive technology ( 25 ). Our findings indicate that patients in the LE group had significantly higher ET, EV, VI, FI, and VFI than patients in the CC group.…”

Section: Discussionmentioning

confidence: 99%

Letrozole Versus Clomiphene Citrate and Natural Cycle: Endometrial Receptivity During Implantation Window in Women With Polycystic Ovary Syndrome

Wang

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveNumerous studies have reported on ovulation and pregnancy rates in patients with polycystic ovary syndrome (PCOS). However, relevant data on endometrial receptivity are limited. This study was conducted to compare endometrial receptivity during implantation windows among letrozole (LE), clomiphene citrate (CC), and natural cycle, and to assess the predictive value for pregnancy of observed indicators.MethodsThis randomized controlled trial study enrolled 270 patients with PCOS. Patients were given LE (n=90) at a dose of 2.5mg/day or CC (n=90) at a dose of 50 mg/day on cycle days 5–9 for ovulation induction. Patients in the natural cycle group (n=90) did not receive any drug for ovulation induction. Endometrial ultrasonic parameters, integrin αvβ3, and vascular endothelial growth factor (VEGF) concentrations in uterine secretion were detected during the implantation window. The endometrial receptivity, ovulation rate, pregnancy rates, and predictive value of observed indicators for pregnancy were analyzed.ResultsThe successful ovulation rate did not differ between the LE group and CC group (P>0.05). Endometrial ultrasonic parameters [endometrial thickness (ET), endometrial volume (EV), vascularization index (VI), flow index (FI), vascularization flow index (VFI)], integrin αvβ3, and VEGF concentrations in uterine fluid were significantly higher in the LE group compared with the CC group and natural cycle group (P<0.05). The clinical pregnancy and ongoing pregnancy rates of the LE group were significantly higher than in the CC group (P<0.05). Endometrial ultrasonic parameters (VI, FI, and VFI), integrin αvβ3, and VEGF concentrations in uterine fluid of all pregnancy groups were significantly higher compared with the no pregnancy group (P<0.05), and the above parameters in ongoing pregnancy were significantly higher than in biochemical pregnancy (P<0.05). The endometrial FI during the implantation window had the highest predictive value for pregnancy (AUC=0.889). The integrin αvβ3 in uterine fluid had better predictive value (AUC=0.876) than VEGF.ConclusionsEndometrial receptivity during the implantation window of LE is superior to CC in PCOS women, which may be related to higher clinical pregnancy and ongoing pregnancy rates. Endometrial FI examined by 3-D power Doppler, and integrin αvβ3 in uterine secretion during the implantation window, could be preferable non-invasive predictor markers for pregnancy.Clinical Trial Registrationwww.chictr.org.cn, ChiCTR1900023423.

show abstract

Section: Discussionmentioning

confidence: 99%

Letrozole Versus Clomiphene Citrate and Natural Cycle: Endometrial Receptivity During Implantation Window in Women With Polycystic Ovary Syndrome

Wang

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…High procedure expenses with low implantation and pregnancy rate in in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) has emerged the need to identify the factors predicting the procedure success. 1,2 Embryo quality and endometrial receptivity are two important factors of ART cycle success. Identifying the factors affecting the endometrial receptivity could improve the outcome.…”

Section: Pregnancymentioning

confidence: 99%

Relationship between thickness and pattern of endometrium and pregnancy rate in in vitro fertilization-intracytoplasmic

Hamdi¹,

Pia²,

Hakimi³

et al. 2018

J Anal Res Clin Med

View full text Add to dashboard Cite

“…It is pointed out that the definition of thin endometrium should be that the endometrial thickness is difficult to successfully support the ET [ 18 ]. Thin endometrium refers to the thickness of the endometrium in the middle luteal phase (after ovulation) of 6–10 days is < 7.0 mm [ 14 , 19 ]. Studies have shown that low pregnancy rate is closely related to the thin endometrium.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture in improving endometrial receptivity: a systematic review and meta-analysis

Zhong

Zeng

Liu

et al. 2019

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundThis systematic review aimed at summarizing and evaluating the evidence of randomized controlled trials (RCTs) using acupuncture to improve endometrial receptivity (ER).MethodsWe searched 12 databases electronically through August 2018 without language restrictions. We included RCTs of women of infertility due to low ER, and excluded infertility caused by other reasons or non-RCTs. Two independent reviewers extracted the characteristics of studies and resolved the differences through consensus. Data were pooled and expressed as standard mean difference (SMD) or mean difference (MD) for continuous outcomes and risk ratio (RR) for dichotomous outcomes, with 95% confidence interval (CI).ResultsWe found very low to moderate level of evidence that acupuncture may improve pregnancy rate (RR = 1.23 95%CI[1.13, 1.34] P < 0.00001) and embryo transfer rate (RR = 2.04 95%CI[1.13, 3.70] P = 0.02), increase trilinear endometrium (RR = 1.47 95%CI [1.27, 1.70] P < 0.00001), thicken endometrium (SMD = 0.41 95% CI [0.11, 0.72] P = 0.008), reduce resistive index (RI) (MD = -0.08 95% CI [− 0.15, − 0.02] P = 0.01), pulse index (PI) (SMD = -2.39 95% CI [− 3.85, − 0.93] P = 0.001) and peak systolic velocity/ end-diastolic blood velocity (S/D) (SMD = -0.60 95% CI [− 0.89, − 0.30] P < 0.0001), compared with medication, sham acupuncture or physiotherapy. Acupuncture was statistically significant as a treatment approach.ConclusionThe efficacy and safety of acupuncture on key outcomes in women with low ER is statistically significant, but the level of most evidence was very low or low. More large-scale, long-term RCTs with rigorous methodologies are needed.

show abstract

Three-dimensional ultrasound as a predictor of pregnancy in patients undergoing ART

Cited by 17 publications

References 39 publications

Letrozole Versus Clomiphene Citrate and Natural Cycle: Endometrial Receptivity During Implantation Window in Women With Polycystic Ovary Syndrome

Letrozole Versus Clomiphene Citrate and Natural Cycle: Endometrial Receptivity During Implantation Window in Women With Polycystic Ovary Syndrome

Relationship between thickness and pattern of endometrium and pregnancy rate in in vitro fertilization-intracytoplasmic

Acupuncture in improving endometrial receptivity: a systematic review and meta-analysis

Contact Info

Product

Resources

About