Three-dimensional structure made with nitrogen-doped reduced graphene oxide with spherical porous morphology

Salazar-Aguilar, Alma D.; Tristan, Ferdinando; Labrada-Delgado, Gladis Judith; Meneses-Rodrı́guez, David; Vega-Díaz, Sofia Magdalena

doi:10.1016/j.carbon.2019.04.016

“…In the FTIR spectra (Supporting Information, Figure S6), the broad peak at 3356 cm −1 associated with −OH stretching vibration directly evidenced the existence of GAG cladding in 4 . Furthermore, the characteristic carbonate ν 4 peak at 712 cm −1 in 3 and 4 further supported the formation of calcite species . Owing to the spin‐orbit splitting, the X‐ray photoelectron spectroscopy (XPS) spectrum showed that the Ca 2p spectrum exhibited two contributions, 2p 3/2 and 2p 1/2 , in 4 (Supporting Information, Figure S7).…”

Section: Resultsmentioning

confidence: 86%

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO₃ for Synergistic Tumor Therapy

Guan

¹

,

Zhou

²

,

Lv

³

et al. 2020

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Ca2+, a ubiquitous but nuanced modulator of cellular physiology, is meticulously controlled intracellularly. However, intracellular Ca2+ regulation, such as mitochondrial Ca2+ buffering capacity, can be disrupted by 1O2. Thus, the intracellular Ca2+ overload, which is recognized as one of the important cell pro‐death factors, can be logically achieved by the synergism of 1O2 with exogenous Ca2+ delivery. Reported herein is a nanoscale covalent organic framework (NCOF)‐based nanoagent, namely CaCO3@COF‐BODIPY‐2I@GAG (4), which is embedded with CaCO3 nanoparticle (NP) and surface‐decorated with BODIPY‐2I as photosensitizer (PS) and glycosaminoglycan (GAG) targeting agent for CD44 receptors on digestive tract tumor cells. Under illumination, the light‐triggered 1O2 not only kills the tumor cells directly, but also leads to their mitochondrial dysfunction and Ca2+ overload. An enhanced antitumor efficiency is achieved via photodynamic therapy (PDT) and Ca2+ overload synergistic therapy.

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“…In addition, Figure C and 4E represent the C 1s high‐resolution spectra of Pd−Mn/rGO and pure GO, respectively. The peaks at 284.6 eV, 285 ev, 286.45 eV and 288.5 eV are correspondingly attributed to un‐oxidized C−C, C=C, C−OH and C=O . Interestingly, the measured CC/CO ratio (2.6) for the Pd−Mn/rGO is greater than that for the GO (2.21), recommending the presence of rGO in the Pd−Mn/rGO nano‐composite.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Non‐enzymatic Electrochemical Glucose Sensor Based on Pd−Mn Alloy Nanoparticles Supported on Reduced Graphene Oxide

Waqas

¹

,

Lan

²

,

Zhang

³

et al. 2020

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Mixed metals alloy nanoparticles supported on carbon nanomaterial are the most attractive candidates for the fabrication of non‐enzymatic electrochemical sensor with enhanced electrochemical performance. In this study, palladium‐manganese alloy nanoparticles supported on reduced graphene oxide (Pd−Mn/rGO) are prepared by a simple reduction protocol. Further, a novel enzyme‐free glucose sensing platform is established based on Pd−Mn/rGO. The successful fabrication of Pd−Mn alloy nanoparticles and their attachment at rGO are thoroughly characterized by various microscopic and spectroscopic techniques such as XRD, Raman, TEM and XPS. The electrochemical activity and sensing features of designed material towards glucose detection are explored by amperometric measurments in 0.1 M NaOH at the working voltage of −0.1 V. Thanks to the newly designed Pd−Mn/rGO nanohybrid for their superior electrorochemical activity towards glucose comprising the admirable sensing features in terms of targeted selectivity, senstivity, two linear parts and good stability. The enhanced electrochemical efficacy of Pd−Mn/rGO electrocatalyst may be credited to the abundant elecrocatalytic active sites formed during the Pd−Mn alloying and the electron transport ability of rGO that augment the electron shuttling phenomenon between the electrode material and targeted analyte.

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“…In the FTIR spectra (Supporting Information, Figure S6), the broad peak at 3356 cm À1 associated with À OH stretching vibration directly evidenced the existence of GAGc ladding in 4.F urthermore,t he characteristic carbonate n 4 peak at 712 cm À1 in 3 and 4 further supported the formation of calcite species. [21] Owing to the spin-orbit splitting,t he X-ray photoelectron spectroscopy (XPS) spectrum showed that the Ca 2p spectrum exhibited two contributions,2p 3/2 and 2p 1/2 ,in4 (Supporting Information, Figure S7). Thet wo peaks located at 347.2 and 350.7 eV (referenced to adventitious C 1s peak [22] at 284.8 eV) were assigned to CaCO 3 (D 2p = 3.5 eV).…”

Section: Resultsmentioning

confidence: 99%

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO₃ for Synergistic Tumor Therapy

Zhou

¹

,

Lv

²

,

Li

³

et al. 2020

View full text Add to dashboard Cite

Ca2+, a ubiquitous but nuanced modulator of cellular physiology, is meticulously controlled intracellularly. However, intracellular Ca2+ regulation, such as mitochondrial Ca2+ buffering capacity, can be disrupted by 1O2. Thus, the intracellular Ca2+ overload, which is recognized as one of the important cell pro‐death factors, can be logically achieved by the synergism of 1O2 with exogenous Ca2+ delivery. Reported herein is a nanoscale covalent organic framework (NCOF)‐based nanoagent, namely CaCO3@COF‐BODIPY‐2I@GAG (4), which is embedded with CaCO3 nanoparticle (NP) and surface‐decorated with BODIPY‐2I as photosensitizer (PS) and glycosaminoglycan (GAG) targeting agent for CD44 receptors on digestive tract tumor cells. Under illumination, the light‐triggered 1O2 not only kills the tumor cells directly, but also leads to their mitochondrial dysfunction and Ca2+ overload. An enhanced antitumor efficiency is achieved via photodynamic therapy (PDT) and Ca2+ overload synergistic therapy.

show abstract

Three-dimensional structure made with nitrogen-doped reduced graphene oxide with spherical porous morphology

Cited by 18 publications

References 46 publications

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO₃ for Synergistic Tumor Therapy

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO₃ for Synergistic Tumor Therapy

Fabrication of Non‐enzymatic Electrochemical Glucose Sensor Based on Pd−Mn Alloy Nanoparticles Supported on Reduced Graphene Oxide

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO₃ for Synergistic Tumor Therapy

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Three-dimensional structure made with nitrogen-doped reduced graphene oxide with spherical porous morphology

Cited by 18 publications

References 46 publications

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO3 for Synergistic Tumor Therapy

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO3 for Synergistic Tumor Therapy

Fabrication of Non‐enzymatic Electrochemical Glucose Sensor Based on Pd−Mn Alloy Nanoparticles Supported on Reduced Graphene Oxide

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO3 for Synergistic Tumor Therapy

Contact Info

Product

Resources

About

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO₃ for Synergistic Tumor Therapy

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO₃ for Synergistic Tumor Therapy

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO₃ for Synergistic Tumor Therapy