Three-dimensional spatial and temporal temperature imaging in gel phantoms using backscattered ultrasound

Anand, Ajay; Savéry, David; Hall, Christopher S.

doi:10.1109/tuffc.2007.208

Cited by 62 publications

(51 citation statements)

References 30 publications

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“…29,30 The changes in speed of sound are then used to estimate temperature elevation in the sample. Using cross correlation techniques to detect time shifts, investigators have claimed the ability to detect changes in temperature as small as 0.5 C with good spatial resolution.…”

Section: Resultsmentioning

confidence: 99%

“…Using cross correlation techniques to detect time shifts, investigators have claimed the ability to detect changes in temperature as small as 0.5 C with good spatial resolution. 30 However, such techniques are limited by motion in the subsequent acquisition scans. 29 Motion artifacts are especially predominant in abdominal organs, e.g., the liver or kidney, where centimeter-sized displacements can cause large estimate errors in micrometer-sized displacements due to sound speed changes.…”

Section: Resultsmentioning

confidence: 99%

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Temperature dependent ultrasonic characterization of biological media

Ghoshal

Luchies

Blue

et al. 2011

The Journal of the Acoustical Society of America

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Quantitative ultrasound (QUS) is an imaging technique that can be used to quantify tissue microstructure giving rise to scattered ultrasound. Other ultrasonic properties, e.g., sound speed and attenuation, of tissues have been estimated versus temperature elevation and found to have a dependence with temperature. Therefore, it is hypothesized that QUS parameters may be sensitive to changes in tissue microstructure due to temperature elevation. Ultrasonic backscatter experiments were performed on tissue-mimicking phantoms and freshly excised rabbit and beef liver samples. The phantoms were made of agar and contained either mouse mammary carcinoma cells (4T1) or chinese hamster ovary cells (CHO) as scatterers. All scatterers were uniformly distributed spatially at random throughout the phantoms. All the samples were scanned using a 20-MHz single-element f/3 transducer. Quantitative ultrasound parameters were estimated from the samples versus increases in temperature from 37C to 50 C in 1 C increments. Two QUS parameters were estimated from the backscatter coefficient [effective scatterer diameter (ESD) and effective acoustic concentration (EAC)] using a spherical Gaussian scattering model. Significant increases in ESD and decreases in EAC of 20%-40% were observed in the samples over the range of temperatures examined. The results of this study indicate that QUS parameters are sensitive to changes in temperature. Gaussian scattering model k wavelength Z 0 acoustic impedance of the surrounding medium Z acoustic impedance of the scatterers q density of the sample

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Temperature dependent ultrasonic characterization of biological media

Ghoshal

Luchies

Blue

et al. 2011

The Journal of the Acoustical Society of America

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“…Important temperature estimation methods in clinics mainly include those based on magnetic resonance and those based on ultrasound (Wu et al, 2002;Mi et al, 2003;Guiot et al, 2004;Parmar and Kolios, 2004;Amini et al, 2005;Arthur et al, 2005aArthur et al, , 2005bMiller et al, 2005;Maleke and Konofagou, 2006;Pousek et al, 2006;Qian et al, 2006;Ren et al, 2006;Wu et al, 2006;Zhang et al, 2006;Anand et al, 2007;Zhong et al, 2007). However, for the methods based on magnetic resonance, the cost is too high, and it cannot be real time.…”

Section: The Status Of Ultrasonic Temperature Estimation Researchmentioning

confidence: 99%

Ultrasound monitoring of temperature and coagulation change during tumor treatment with microwave ablation

Yang

Bai

et al. 2009

Front. Biol. China

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Microwave ablation therapy has become an important method for tumor treatment in recent years. The temperature and the coagulation region need real-time noninvasive monitoring to ensure the safety and effectiveness during the treatment. The authors reviewed the ultrasonic monitoring methods for tumor microwave ablation therapy both at home and abroad. In addition, the authors also prospected this technique in the future.

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“…Because of its attractiveness, several ultrasonic techniques have been investigated for monitoring, quantifying, and mapping the temperature rises induced in tissues by HIFU treatment. The most widely explored approach to ultrasonic thermometry is to quantify the changes in speed of sound and/or attenuation [6][7][8][9]. However, these techniques are susceptible to tissue motion and depend on the specific tissue properties to deduce temperature changes from changes in sound speed or attenuation.…”

Section: Introductionmentioning

confidence: 99%

Quantitative imaging of temperature elevations in tissues due to thermal therapies

Kemmerer

Ghoshal

Oelze

et al. 2014

2014 IEEE International Ultrasonics Symposium

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Abstract-Thermal ablation and hyperthermia remain as potent treatment options for cancer. However, the inability to closely monitor temperature elevations from thermal therapies in real time continues to limit clinical applicability. Therefore, the development of new imaging techniques capable of providing feedback and temperature monitoring is highly medically significant. In this study, quantitative ultrasound imaging techniques based on spectral estimates were examined for their ability to monitor and map temperature elevations induced in tissues using either microwave ablation or high intensity focused ultrasound (HIFU).Ex vivo liver samples were treated with microwave ablation while ultrasound image frames were recorded using a SonixTouch system and linear array (14L5). In vivo tumors in rats (MAT) were treated using a custom-built HIFU system while concurrently imaged using a SonixRP scanner and linear array (14L5). The ultrasound scanners provided raw radio frequency (RF) data. From the RF data, the backscatter coefficient was calculated using the reference phantom technique. The backscatter coefficient was parameterized by estimating an effective scatterer diameter (ESD) and effective acoustic concentration (EAC) assuming a spherical Gaussian model. Maps of the ESD and EAC were created for each acquired frame. Temperature was measured by placing a needle thermocouple in the samples during treatment and temperature changes were correlated with changes in the scattering parameters.In the ex vivo liver samples, the ESD was observed to increase with temperature elevation while the EAC was observed to decrease with temperature elevation. Specifically, the mean ESD increased by 7 μm and EAC decreased by 1.5 dB as the temperature increased from 18 to 42 °C. Conversely, in the in vivo tumor samples treated with HIFU, the EAC was observed to increase with increasing temperature, i.e., the EAC increased by 20 to 30% as the temperature increased from 37 °C to a range of 50 to 60 °C. When the HIFU was turned off, the EAC continued to track the decrease in temperature of the tumor. In the in vivo studies, the tumors were grown on the chest wall of the rats and, therefore, large out of plane tissue motion occurred due to the breathing of the animal. In spite of this, the EAC parameter was capable of tracking temperature in the presence of large tissue motion.

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Three-dimensional spatial and temporal temperature imaging in gel phantoms using backscattered ultrasound

Cited by 62 publications

References 30 publications

Temperature dependent ultrasonic characterization of biological media

Temperature dependent ultrasonic characterization of biological media

Ultrasound monitoring of temperature and coagulation change during tumor treatment with microwave ablation

Quantitative imaging of temperature elevations in tissues due to thermal therapies

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