Three-dimensional printing of stimuli-responsive hydrogel with antibacterial activity

Ramesh, Srikanthan; Kovelakuntla, Vamsi; Meyer, Anne S.

doi:10.1016/j.bprint.2020.e00106

Cited by 29 publications

(19 citation statements)

References 45 publications

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“…[85] Osteoblast cells incorporated in chitosan hydrogel. [86] Silk-gelatin hydrogel embedded with mesenchymal stem cells. [297] Biological engineered tissues Induced pluripotent stem cells contained in crosslinked hydrogel comprising alginate, chitosan and agarose.…”

Section: Skin Tissuementioning

confidence: 99%

“…Moreover, extracellular matrix formation was observed when bio-ink contained chitosan. Another study by Ramesh et al focused on the preparation of scaffolds using a thermo- and pH-responsive chitosan-based bio-ink composed of chitosan and glycerol phosphate [ 86 ]. This thermo- and pH-responsive chitosan-based bio-ink was shown to present antibacterial activity when formulated with zinc oxide nanoparticles, while also retaining the osteoconductivity of the chitosan-based bio-ink hydrogel.…”

Section: Formulation and Use Of Natural Hydrogel-based Bio-inksmentioning

confidence: 99%

“…This type of bioprinting material is known to have higher regenerative potential than conventional commercial hydrogels [ 82 , 83 ]. Crucially, the capacity of 3D bioprinting of hydrogel-based bio-inks has been demonstrated in the regeneration of several types of damaged tissues, including heart [ 84 ], cartilage [ 50 , 63 , 66 , 78 ], bone [ 85 , 86 , 87 , 88 ], muscle [ 81 , 89 , 90 ], kidney [ 29 , 89 ], skin [ 30 , 49 , 90 , 91 , 92 ], blood vessels [ 53 , 93 , 94 ], adipose tissue [ 95 , 96 ], intestinal tissue [ 97 ], liver [ 98 ], trachea graft [ 37 ], breast tissue [ 99 ], ocular tissue [ 100 ] and other engineered biological tissues [ 101 , 102 ].…”

Section: Introductionmentioning

confidence: 99%

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Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Fatimi

Okoro

Podstawczyk

et al. 2022

Gels

128

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Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due to the increasing global demand for organ replacement and tissue regeneration. In 3D bioprinting, which is a step ahead of 3D biomaterial printing, the ink employed is impregnated with cells, without compromising ink printability. This allows for immediate scaffold cellularization and generation of complex structures. The use of cell-laden inks or bio-inks provides the opportunity for enhanced cell differentiation for organ fabrication and regeneration. Recognizing the importance of such bio-inks, the current study comprehensively explores the state of the art of the utilization of bio-inks based on natural polymers (biopolymers), such as cellulose, agarose, alginate, decellularized matrix, in 3D bioprinting. Discussions regarding progress in bioprinting, techniques and approaches employed in the bioprinting of natural polymers, and limitations and prospects concerning future trends in human-scale tissue and organ fabrication are also presented.

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Section: Skin Tissuementioning

confidence: 99%

Section: Formulation and Use Of Natural Hydrogel-based Bio-inksmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Fatimi

Okoro

Podstawczyk

et al. 2022

Gels

128

View full text Add to dashboard Cite

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“…Furthermore, the antibacterial activity of scaffolds was derived from their interaction with the bacterial cell wall, penetrating the cell wall to inhibit DNA replication and covering the cell wall of bacteria to hinder the transport of nutrients [ 102 ]. The antibacterial property of CS was insufficient to address the complicated requirements of bone implant-associated infection; however, it may be coupled with other antibacterial materials, such as ions and drugs, to enhance antibacterial capabilities, as detailed in the combined strategies section [ [110] , [111] , [112] , [113] ].…”

Section: Bioceramic-based Scaffolds With Physical Antibacterial Funct...mentioning

confidence: 99%

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Zhao

Liu

Zhu

et al. 2022

Bioactive Materials

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“…Films obtained using alginate/gelatin/ZnO composition showed increased antimicrobial activity against two pathogens and improved tensile strength (Ahmed, Mulla, Joseph, et al, 2020). Taking a step further and targeting BTE applications, another study focused on designing a thermo‐ and pH‐responsive polymeric formulation based on chitosan and glycerol phosphate, the incorporation of ZnO nanoparticles granting exceptional antimicrobial activity (Ramesh et al, 2020). Advancing toward wound healing therapy, alginate‐based printing inks embedding ZnO revealed significantly stiffer gels with an elastic modulus up to 65 kPa, decreased bacterial growth and higher moisture retention (Cleetus et al, 2020).…”

Section: Approaches To 3d Printing Hydrogels Incorporating 0d To 2d Nanocompoundsmentioning

confidence: 99%

Nanoengineered biomimetic hydrogels: A major advancement to fabricate 3D‐printed constructs for regenerative medicine

Cernencu

Dinu

Stancu

et al. 2022

Biotech & Bioengineering

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Nanostructured compounds already validated as performant reinforcements for biomedical applications together with different fabrication strategies have been often used to channel the biophysical and biochemical features of hydrogel networks. Ergo, a wide array of nanostructured compounds has been employed as additive materials integrated with hydrophilic networks based on naturally‐derived polymers to produce promising scaffolding materials for specific fields of regenerative medicine. To date, nanoengineered hydrogels are extensively explored in (bio)printing formulations, representing the most advanced designs of hydrogel (bio)inks able to fabricate structures with improved mechanical properties and high print fidelity along with a cell‐interactive environment. The development of printing inks comprising organic–inorganic hybrid nanocomposites is in full ascent as the impact of a small amount of nanoscale additive does not translate only in improved physicochemical and biomechanical properties of bioink. The biopolymeric nanocomposites may even exhibit additional particular properties engendered by nano‐scale reinforcement such as electrical conductivity, magnetic responsiveness, antibacterial or antioxidation properties. The present review focus on hydrogels nanoengineered for 3D printing of biomimetic constructs, with particular emphasis on the impact of the spatial distribution of reinforcing agents (0D, 1D, 2D). Here, a systematic analysis of the naturally‐derived nanostructured inks is presented highlighting the relationship between relevant length scales and size effects that influence the final properties of the hydrogels designed for regenerative medicine.

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Three-dimensional printing of stimuli-responsive hydrogel with antibacterial activity

Cited by 29 publications

References 45 publications

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Nanoengineered biomimetic hydrogels: A major advancement to fabricate 3D‐printed constructs for regenerative medicine

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