Three-dimensional printing of bioactive hernia meshes: In vitro proof of principle

Ballard, David H.; Weisman, Jeffery A.; Jammalamadaka, Uday; Tappa, Karthik; Alexander, J. Steven; Griffen, F. Dean

doi:10.1016/j.surg.2016.08.033

Cited by 41 publications

(71 citation statements)

References 4 publications

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“…The ability to create 3D devices and scaffolds that are patient-specific and tunable holds great promise in the surgical repair of orofacial and maxillofacial defects. In this study, we used a 3D printing method that fabricates customized and antibiotic thermoplastic filaments for 3D printing [14][15][16]. 3D printed stents were successfully fabricated into antibiotic, porous, and mesh forms, and whose properties can be mechanically enhanced or modified.…”

Section: Discussionmentioning

confidence: 99%

“…3D printed stents were successfully fabricated into antibiotic, porous, and mesh forms, and whose properties can be mechanically enhanced or modified. As FDM uses a layer-by-layer approach, the printed stent has the antibiotic distributed throughout the device and should assist in preventing infection leading to tissue repair and regeneration [14,15].…”

Section: Discussionmentioning

confidence: 99%

“…Developments over the last ten years have shown that 3D printing has found its place in medicine, bio-, and nanotechnology, thus paving the way for the rapid printing of medicine, artificial devices and prosthetics, and even human tissue [8][9][10]. Currently, there is an intense research effort focused on the application of 3D printing and bioprinting for the development of blood vessels [8][9][10], bioengineered tissues [11,12], and the production of functional biomedical materials and devices for dental and orthopedic applications [13][14][15][16]. The advantages offered by 3D printing include fast and accurate fabrication of structures with complex 3D features, high reproducibility, ease of manufacture, and the ability to produce customized medical devices [6,7,16].…”

Section: Introductionmentioning

confidence: 99%

“…The most commonly used biocompatible materials that are used for implantable constructs include polylactic acid (PLA), polyglycolic acid (PGLA), polycaprolactone (PCL), and blends of polyethylene glycol (PEG). These are being as blends and in composites to produce new and innovative biomedical devices, including prosthetics [28,29], implants [14,15,30], and scaffolding for regenerative medicine [30][31][32]. 3D printing offers the potential for a more customized and patient-specific treatment [33].…”

Section: Introductionmentioning

confidence: 99%

“…We used these thermoplastics in developing a novel three-dimensional (3D) printing method designed for infection prophylaxis, cancer remediation, and disease prevention [14][15][16]. This method enables the printing of a single bead, or beads within a string, as disks in filament forms, catheters, medical mesh, or other desired shapes [14,15].…”

Section: Introductionmentioning

confidence: 99%

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The Use of 3D Printing in the Fabrication of Nasal Stents

et al. 2017

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Nasoalveolar molding of the cleft lip, nose, and alveolar palate has been a successful strategy for the restoration of oronasal function and appearance, but it has some drawbacks. The temporary implant that is inserted before surgical reconstruction is a large appliance requiring numerous adjustments, it can irritate delicate soft tissues, and interfere with the infant's ability to nurse or feed. In the early post-operative period and for months after cleft lip repair, patients wear standardized silicone stents that come in multiple sizes, but require significant sculpting to fit the unique cleft deformity. Three-dimensional (3D) printing offers the potential of highly personalized and patient-specific treatment. We developed a method that produces a customized 3D printed stent that matches the contours and unique features of each patient and permits modification and adjustments in size and shape as the patient ages. With 3D scanning technology, the device can be designed at the first visit to create an appliance that can be worn sequentially with minimal trauma, does not impede feeding, and a prosthesis that will improve compliance. The device will be worn intraorally to help shape the alveolus, lip, and nose before surgical repair. Furthermore, the stent can be doped with drugs as each patient's case warrants.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Use of 3D Printing in the Fabrication of Nasal Stents

et al. 2017

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Personalized additive manufacturing of devices for the management of enteroatmospheric fistulas

Calero Castro,

Padillo Eguía,

Durán Muñoz‐Cruzado

et al. 2023

Bioengineering & Transla Med

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Additive manufacturing techniques allow the customized design of medical devices according to the patient's requirements. Enteroatmospheric fistula is a pathology that benefits from this personalization due to its extensive clinical variability since the size and morphology of the wound differ extensively among patients. Standard prosthetics do not achieve proper isolation of the wound, leading to a higher risk of infections. Currently, no effective personalized technique to isolate it has been described. In this work, we present the workflow for the design and manufacture of customized devices adapted to the fistula characteristics as it evolves and changes during the treatment with Negative Pressure Wound Therapy (NPWT). For each case, a device was designed with dimensions and morphology depending on each patient's requirements using white light scanning, CAD design, and additive manufacturing. The design and manufacture of the devices were performed in 230.50 min (184.00–304.75). After the placement of the device, the wound was successfully isolated from the intestinal content for 48–72 h. The therapy was applied for 27.71 ± 13.74 days, and the device was redesigned to adapt to the wound when geometrical evolutionary changes occur during the therapy. It was observed a decrease in weekly cures from 23.63 ± 10.54 to 2.69 ± 0.65 (p = 0.001). The fistulose size was reduced longitudinal and transversally by 3.25 ± 2.56 cm and 6.06 ± 3.14 cm, respectively. The wound depth also decreased by 1.94 ± 1.08 cm. In conclusion, customization through additive manufacturing is feasible and offers promising results in the generation of personalized devices for the treatment of enteroatmospheric fistula.

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Prosthetic meshes for hernia repair: State of art, classification, biomaterials, antimicrobial approaches, and fabrication methods

Serrano‐Aroca

Pous‐Serrano

2021

J Biomedical Materials Res

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Worldwide, hernia repair represents one of the most frequent surgical procedures encompassing a global market valued at several billion dollars. This type of surgery usually requires the implantation of a mesh that needs the appropriate chemical, physical and biological properties for the type of repair. This review thus presents a description of the types of hernias, current hernia repair methods, and the state of the art of prosthetic meshes for hernia repair providing the most important meshes used in clinical practice by surgeons working in this area classified according to their biological or chemical nature, morphology and whether bioabsorbable or not. We emphasise the importance of surgical site infection in herniatology, how to deal with this microbial problem, and we go further into the future research lines on the production of advanced antimicrobial meshes to improve hernia repair and prevent microbial infections, including multidrug-resistant strains. A great deal of progress has been made in this biomedical field in the last decade. However, we are still far from an ideal antimicrobial mesh that can also provide excellent integration to the abdominal wall, mechanical performance, low visceral adhesion and minimal inflammatory or foreign body reactions, among many other problems.

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Three-dimensional printing of bioactive hernia meshes: In vitro proof of principle

Cited by 41 publications

References 4 publications

The Use of 3D Printing in the Fabrication of Nasal Stents

The Use of 3D Printing in the Fabrication of Nasal Stents

Personalized additive manufacturing of devices for the management of enteroatmospheric fistulas

Prosthetic meshes for hernia repair: State of art, classification, biomaterials, antimicrobial approaches, and fabrication methods

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