Three-dimensional printing in ophthalmology and eye care: current applications and future developments

Fakhoury, Yazan; Ellabban, Abdallah A.; Attia, Usama M.; Sallam, Ahmed; Elsherbiny, Samer

doi:10.1177/25158414221106682

Cited by 7 publications

(3 citation statements)

References 81 publications

(94 reference statements)

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“…Anterior segment OCT can also assess the impact of soft contact lens edge design and mid-peripheral shape on the epithelial thickness and central and peripheral tear film clearance in various hard lens models. 61 , 62 …”

Section: Resultsmentioning

confidence: 99%

Keratoconus: exploring fundamentals and future perspectives – a comprehensive systematic review

Niazi,

Gatzioufas,

Doroodgar

et al. 2024

Ophthalmol Eye Dis

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Background: New developments in artificial intelligence, particularly with promising results in early detection and management of keratoconus, have favorably altered the natural history of the disease over the last few decades. Features of artificial intelligence in different machine such as anterior segment optical coherence tomography, and femtosecond laser technique have improved safety, precision, effectiveness, and predictability of treatment modalities of keratoconus (from contact lenses to keratoplasty techniques). These options ingrained in artificial intelligence are already underway and allow ophthalmologist to approach disease in the most non-invasive way. Objectives: This study comprehensively describes all of the treatment modalities of keratoconus considering machine learning strategies. Design: A multidimensional comprehensive systematic narrative review. Data sources and methods: A comprehensive search was done in the five main electronic databases (PubMed, Scopus, Web of Science, Embase, and Cochrane), without language and time or type of study restrictions. Afterward, eligible articles were selected by screening the titles and abstracts based on main mesh keywords. For potentially eligible articles, the full text was also reviewed. Results: Artificial intelligence demonstrates promise in keratoconus diagnosis and clinical management, spanning early detection (especially in subclinical cases), preoperative screening, postoperative ectasia prediction after keratorefractive surgery, and guiding surgical decisions. The majority of studies employed a solitary machine learning algorithm, whereas minor studies assessed multiple algorithms that evaluated the association of various keratoconus staging and management strategies. Last but not least, AI has proven effective in guiding the implantation of intracorneal ring segments in keratoconus corneas and predicting surgical outcomes. Conclusion: The efficient and widespread clinical translation of machine learning models in keratoconus management is a crucial goal of potential future approaches to better visual performance in keratoconus patients. Trial registration: The article has been registered through PROSPERO, an international database of prospectively registered systematic reviews, with the ID: CRD42022319338

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Section: Resultsmentioning

confidence: 99%

Keratoconus: exploring fundamentals and future perspectives – a comprehensive systematic review

Niazi,

Gatzioufas,

Doroodgar

et al. 2024

Ophthalmol Eye Dis

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“…The development of tailored ocular prostheses for the patients with eye loss is a long, hard, and expensive process, however. It is possible to obtain desired objects via user-controllable computer aided designs in 3D-printing [ 146 , 147 ]. Therefore, manufacturing a patient-specific ocular prosthesis by the means of 3D-printing is available.…”

Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

“…It is an emerging technology for the fabrication of complex-structured tissue and organs. Therefore, it is a promising technology for the replacement of tissues such as cornea, retina, and tarsal plate in cornea, external eye, and other ocular diseases [ 147 ]. In ocular diseases 3D-printed drug delivery systems are also manufactured for “personalized medicine” applications.…”

Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of contact lenses, micro and nanoneedles and in situ gels, have been introduced which can overcome the previously mentioned barriers. These novel techniques could enhance the bioavailability of therapeutic components inside the eyes, deliver them to the posterior side of the eyes, release them in a controlled manner, and reduce the side effects of previous methods (such as eye drops). Accordingly, this review paper aims to summarize some of the evidence on the effectiveness of these new techniques for treating ocular disease, their preclinical and clinical progression, current limitations, and future perspectives.

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Manufacturing and characterisation of 3D-printed sustained-release Timolol implants for glaucoma treatment

Paleel,

Qin,

Tagalakis

et al. 2024

Drug Deliv. and Transl. Res.

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Timolol maleate (TML) is a beta-blocker drug that is commonly used to lower the intraocular pressure in glaucoma. This study focused on using a 3D printing (3DP) method for the manufacturing of an ocular, implantable, sustained-release drug delivery system (DDS). Polycaprolactone (PCL), and PCL with 5 or 10% TML implants were manufactured using a one-step 3DP process. Their physicochemical characteristics were analysed using light microscopy, scanning electronic microscopy (SEM), differential scanning calorimetry (DSC) / thermal gravimetric analysis (TGA), and Fourier-transform infrared spectroscopy (FTIR). The in vitro drug release was evaluated by UV-spectrophotometry. Finally, the effect of the implants on cell viability in human trabecular meshwork cells was assessed. All the implants showed a smooth surface. Thermal analysis demonstrated that the implants remained thermally stable at the temperatures used for the printing, and FTIR studies showed that there were no significant interactions between PCL and TML. Both concentrations (5 & 10%) of TML achieved sustained release from the implants over the 8-week study period. All implants were non-cytotoxic to human trabecular cells. This study shows proof of concept that 3DP can be used to print biocompatible and personalised ocular implantable sustained-release DDSs for the treatment of glaucoma. Graphical Abstract

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Three-dimensional printing in ophthalmology and eye care: current applications and future developments

Cited by 7 publications

References 81 publications

Keratoconus: exploring fundamentals and future perspectives – a comprehensive systematic review

Keratoconus: exploring fundamentals and future perspectives – a comprehensive systematic review

Application of Convergent Science and Technology toward Ocular Disease Treatment

Manufacturing and characterisation of 3D-printed sustained-release Timolol implants for glaucoma treatment

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