Three-dimensional imaging of past skeletal TB: From lesion to process

Coqueugniot, Hélène; Dutailly, Bruno; Desbarats, Pascal; Boulestin, Bruno; Pap, Ildikó; Szikossy, Ildikó; Baker, Oussama; Montaudon, Michel; Panuel, M.; Karlinger, Kinga; Kovács, Balazs; Kristóf, Lilla Alida; Paragh, György; Dutour, Olivier

doi:10.1016/j.tube.2015.02.004

Cited by 17 publications

(7 citation statements)

References 10 publications

(13 reference statements)

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“…Large sequestra are absent, and PO21 displays very little perifocal reactive new bone formation; the lesions are primarily or exclusively lytic. The exposed cancellous bone is characterized by increased trabecular separation and thickened trabeculae, suggesting a process of damage and repair (Figure 4; see also Figure 2 in Coqueugniot et al, 2015). In the long bones, in this case in the humerus, the diaphyses are not involved, and lytic processes are localized in the epiphyses.…”

Section: Differential Diagnosismentioning

confidence: 98%

A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

Sparacello

Roberts

Kerudin

et al. 2017

International Journal of Paleopathology

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Citation for published item: p r elloD it le F nd o ertsD gh rlotte eF nd uerudinD emmielle nd w¤ ullerD omy @PHIUA 9e TSHHEye rEold widdle xeolithi hild from oller g ve @viguri D st lyA with pro le multifo l osteo rti ul r tu er ulosisF9D sntern tion l journ l of p leop thologyFD IU F ppF TUEURF Further information on publisher's website: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details.

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Section: Differential Diagnosismentioning

confidence: 98%

A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

Sparacello

Roberts

Kerudin

et al. 2017

International Journal of Paleopathology

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“…Indeed, it seems that the vertebrae did not collapse in spite of the importance of the destruction of the vertebral bodies, which is confirming the existence of a space occupying mass (such as a granulomatous cyst) that has probably protected the thoracic spine from crush. This pattern is not commonly described in modern clinical practice, but can be seen by medical imaging on living patients 29 and mummified bodies 28 and has been clearly identified on skeletal material 27…”

Section: Paleopathologymentioning

confidence: 88%

“…The burial had no direct link with architecture, but according to the stratigraphic level the skeleton can be dated to the "DJ 2" phase. 27,28 Using 3D reconstruction from laser surface acquisition, it has been possible to reassemble precisely the zygapophyseal joints and thus to get a more precise view of the spinal static. Indeed, it seems that the vertebrae did not collapse in spite of the importance of the destruction of the vertebral bodies, which is confirming the existence of a space occupying mass (such as a granulomatous cyst) that has probably protected the thoracic spine from crush.…”

Section: Paleopathologymentioning

confidence: 99%

Human tuberculosis predates domestication in ancient Syria

Baker

Lee

et al. 2015

Tuberculosis

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The question of pre-neolithic tuberculosis is still open in paleopathological perspective. One of the major interests is to explore what type of infection could have existed around the early stage of animal domestication. Paleopathological lesions evoking skeletal TB were observed on five human skeletons coming from two PPNB sites in Syria, which belongs to the geographical cradle of agriculture. These sites represent respectively pre-domestication phase (Dja'de el Mughara, Northern Syria, 8800-8300 BCE cal.) and early domestication phase (Tell Aswad, Southern Syria, 8200-7600 BCE cal.). MicroCT scan analyses were performed on two specimens (one per site) and revealed microscopic changes in favor of TB infection. Detection of lipid biomarkers is positive for two specimens (one per site). Initial molecular analysis further indicates the presence of TB in one individual from Dja'de. Interestingly, no morphological evidence of TB was observed on animal remains of wild and newly domesticated species, discovered in these sites. These observations strongly suggest the presence of human tuberculosis before domestication and at its early stages.

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“…Moreover, the bones were analysed radiologically, with conventional digital radiography and clinical computed tomography (direct digital Fujifilm machine, exposure [100 ms] 55 kV, 100 mA) performed at the Gaetano and Piera Borghi Foundation, Brebbia, Varese, Italy. The size and shape of the spinal canal was analysed according to what is proposed by Coqueugniot et al (). The abnormal bone loss was scored according to the anthropological standards (Buikstra & Ubelaker, ) and a more in‐depth analysis of the lesions was possible thanks to the work of Mariotti et al ().…”

Section: Methodsmentioning

confidence: 99%

A probable case of subligamentous tuberculous spondylitis: The concealed body of the Late Modern Period (early 16th century to early 20th century), Franciscan crypt of St. Anthony and St. Eusebius church, Lombardy, Italy

Larentis

Tonina

Tesi

et al. 2019

Intl J of Osteoarchaeology

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This paper presents a probable case of subligamentous tuberculous spondylitis (STBS), a rare form of extrapulmonary tuberculosis, diagnosed in the skeleton of a middle‐aged male discovered in the ossuary of the Franciscan crypt of the St. Anthony and St. Eusebius church, which lies in north‐western Italy. The skeleton can be dated back between the 17th and 19th centuries. This rare type of tuberculosis was identified in the thoracic and lumbar spine, with no further evidences at the level of the cranial and other postcranial bones. The concomitance of osteoclastic and osteoblastic activities, scalloping, reactive bone formation area, anterior, and lateral ligaments ossification was observed and allowed us to perform a morphological STBS diagnosis. The subject presented here contributes to the literature related to the prevalence of tuberculosis in Italy during the last centuries. Moreover, we also focus our attention on some osteopathological criteria that can prove useful for the diagnosis of extrapulmonary tuberculosis.

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Three-dimensional imaging of past skeletal TB: From lesion to process

Cited by 17 publications

References 10 publications

A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

Human tuberculosis predates domestication in ancient Syria

A probable case of subligamentous tuberculous spondylitis: The concealed body of the Late Modern Period (early 16th century to early 20th century), Franciscan crypt of St. Anthony and St. Eusebius church, Lombardy, Italy

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